Neural Networks and Rules-based Systems used to Find Rational and Scientific Correlations between being Here and Now with Afterlife Conditions
Neural Networks and Rules-based Systems used to Find Rational and
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A first order stochastic semi-empirical model for pharmacokinetics is presented and the real response of drug concentration to vital pharmacokinetics parameters studied. By invoking Gaussian kinetics and the residual drug concentration eliminated, the probability densities and the response of concentration profiles are theoretically simulated, using empirical data based on our experience. The drug is administered for 3 days at regular time intervals of 3hr and 6hr, respectively, by refreshing the drug halflife. Results show that the amount of drug residue decreases with increasing dose, but increases with increase in ingestion time interval for corresponding dose. It is also shown that the real drug concentration increases to a threshold and decreases marginally for subsequent dose. However it is difficult to predict the response of drug concentration with changes in ingestion time interval. We recommend that for higher drug concentration the half-life be increased. Our simulation results qualitatively agree with those documented in the literatures.
C.I. Okoro. 2013. \u201cA Stocastic Semi-Empirical Model for First Order Decay Pharmacokinetics\u201d. Global Journal of Science Frontier Research - A: Physics & Space Science GJSFR-A Volume 13 (GJSFR Volume 13 Issue A6): .
Crossref Journal DOI 10.17406/GJSFR
Print ISSN 0975-5896
e-ISSN 2249-4626
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Total Score: 102
Country: Nigeria
Subject: Global Journal of Science Frontier Research - A: Physics & Space Science
Authors: I.C., Okoro (PhD/Dr. count: 0)
View Count (all-time): 102
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Publish Date: 2013 08, Sat
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A first order stochastic semi-empirical model for pharmacokinetics is presented and the real response of drug concentration to vital pharmacokinetics parameters studied. By invoking Gaussian kinetics and the residual drug concentration eliminated, the probability densities and the response of concentration profiles are theoretically simulated, using empirical data based on our experience. The drug is administered for 3 days at regular time intervals of 3hr and 6hr, respectively, by refreshing the drug halflife. Results show that the amount of drug residue decreases with increasing dose, but increases with increase in ingestion time interval for corresponding dose. It is also shown that the real drug concentration increases to a threshold and decreases marginally for subsequent dose. However it is difficult to predict the response of drug concentration with changes in ingestion time interval. We recommend that for higher drug concentration the half-life be increased. Our simulation results qualitatively agree with those documented in the literatures.
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