A Study of the Psychotropic Activity of Extracts of Hedysarum Alpinum L. and Garcinia Mangostana L.

1
Fedorova Yu.S.
Fedorova Yu.S.
2
Kulpin P.V.
Kulpin P.V.
3
Suslov N.I.
Suslov N.I.
4
Denisova S.V
Denisova S.V
5
Tretyak V.M.
Tretyak V.M.
6
Merkuryeva A.G.
Merkuryeva A.G.
7
Beregovykh G.V.
Beregovykh G.V.
8
Barkin I.M.
Barkin I.M.
9
Lyamin E .S.
Lyamin E .S.
1 Kemerovo State Medical University, Kemerovo, Russia;

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The present research featured extracts of Hedysarum alpinum L. and Garcinia mangostana L. The extract of Hedysarum alpinum L. proved to have a more pronounced effect on the dopamine-induced changes in animal behavior in an active avoidance conditioning model as compared with such popular antipsychotic drug as haloperidol. Methodology: The antipsychotic effect was evaluated based on active avoidance conditioning model in a two-compartment shuttle chamber. The anti-anxiety effect was evaluated in terms of passive avoidance conditioning. The side depressive effect of the extracts was evaluated based on the behavior of the animals during the Open Field test.

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

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Not applicable for this article.

Fedorova Yu.S.. 2020. \u201cA Study of the Psychotropic Activity of Extracts of Hedysarum Alpinum L. and Garcinia Mangostana L.\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 20 (GJMR Volume 20 Issue B4): .

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Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-B Classification: NLMC Code: QV 752
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v1.2

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May 11, 2020

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English

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The present research featured extracts of Hedysarum alpinum L. and Garcinia mangostana L. The extract of Hedysarum alpinum L. proved to have a more pronounced effect on the dopamine-induced changes in animal behavior in an active avoidance conditioning model as compared with such popular antipsychotic drug as haloperidol. Methodology: The antipsychotic effect was evaluated based on active avoidance conditioning model in a two-compartment shuttle chamber. The anti-anxiety effect was evaluated in terms of passive avoidance conditioning. The side depressive effect of the extracts was evaluated based on the behavior of the animals during the Open Field test.

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A Study of the Psychotropic Activity of Extracts of Hedysarum Alpinum L. and Garcinia Mangostana L.

Fedorova Yu.S.
Fedorova Yu.S. Kemerovo State Medical University, Kemerovo, Russia;
Kulpin P.V.
Kulpin P.V.
Suslov N.I.
Suslov N.I.
Denisova S.V
Denisova S.V
Tretyak V.M.
Tretyak V.M.
Merkuryeva A.G.
Merkuryeva A.G.
Beregovykh G.V.
Beregovykh G.V.
Barkin I.M.
Barkin I.M.
Lyamin E .S.
Lyamin E .S.

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