A Study on Cold Agglutinins in Malaria from a Tertiary Care Hospital of South India

α
Venkatesh VN
Venkatesh VN
σ
Venkatesh V.N
Venkatesh V.N
ρ
Ravish Kumar M
Ravish Kumar M
Ѡ
Nagendra Gowda M. R
Nagendra Gowda M. R
α Rajiv Gandhi University of Health Sciences

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A Study on Cold Agglutinins in Malaria from a Tertiary Care Hospital of South India

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Abstract

Background: Malarial infection associated with common hematological abnormalities like anemia, Thrombocytopenia, Hemolytic anemia. Hemolytic anemia is due to occurrence of cold agglutinins. This study throws light on the prevalence of cold agglutinins in patients with malarial infection and their detection. Method: About 150 patients diagnosed as having Malaria by Peripheral smear, QBC for malaria or by Rappid diagnostic test for Malaria were studied for occurrence of cold agglutinins by Cold agglutinin test. Results: Out of 150 Patients, who are diagnosed as positive for malaria, 83.3% of the patients had negative for cold agglutinin and only (4%) were found to have high titers of cold agglutinins. The mean age group of the patients who were positive for the test was 45.25 ± 19.7 years. The Hemoglobin percentage and platelet count in cold agglutinin positive patients were 8.85 (± 3.72) gms% and 1, 03, 500 (± 1.16) respectively.

References

8 Cites in Article
  1. Vijay Sonawane (2000). Comparison of Clinical Profile and Severity of P. falciparum and P. vivax Malaria in a Tertiary Care Hospital of NaviMumbai, India: A Descriptive Study.
  2. A Layla,Bashawri,A Ahmed,A Ahmed,A Mirghani (2002). Malaria: haematological aspects.
  3. D Claudio,D Pierre,M Loic,C Jean,G Marc (1983). Specificity of auto antibodies in malaria and the role of polyclonal activation.
  4. F Constantin,F G Luis,S Adolfo,C Alysson,Cor Jesus,F Erika,M Nelson,M (2005). Increased polyclonal immunoglobulin reactivity toward human and bacterial proteins is associated with clinical protection in human Plasmodium infection.
  5. C Facer (1980). Direct antiglobulin reactions in Gambian children with P. falciparum malaria.
  6. J Torres,L Villegas,H Perez,L Suarez,Vma Torres,M Campos (2003). Low grade parasitaemia and cold agglutinins in patients with hyper-reactive malarious splenomegaly and acute haemolysis.
  7. G Sharon,F Richard,M Rajalakshmi,L Harry (2002). eMedicine Cold Agglutinin Disease.
  8. Robert Maina,Douglas Walsh,Charla Gaddy,Gordon Hongo,John Waitumbi,Lucas Otieno,David Jones,Bernhards Ogutu (2010). Impact of Plasmodium falciparum infection on haematological parameters in children living in Western Kenya.

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Venkatesh VN. 2014. \u201cA Study on Cold Agglutinins in Malaria from a Tertiary Care Hospital of South India\u201d. Global Journal of Medical Research - C: Microbiology & Pathology GJMR-C Volume 14 (GJMR Volume 14 Issue C1): .

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords
Version of record

v1.2

Issue date

March 8, 2014

Language
en
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Background: Malarial infection associated with common hematological abnormalities like anemia, Thrombocytopenia, Hemolytic anemia. Hemolytic anemia is due to occurrence of cold agglutinins. This study throws light on the prevalence of cold agglutinins in patients with malarial infection and their detection. Method: About 150 patients diagnosed as having Malaria by Peripheral smear, QBC for malaria or by Rappid diagnostic test for Malaria were studied for occurrence of cold agglutinins by Cold agglutinin test. Results: Out of 150 Patients, who are diagnosed as positive for malaria, 83.3% of the patients had negative for cold agglutinin and only (4%) were found to have high titers of cold agglutinins. The mean age group of the patients who were positive for the test was 45.25 ± 19.7 years. The Hemoglobin percentage and platelet count in cold agglutinin positive patients were 8.85 (± 3.72) gms% and 1, 03, 500 (± 1.16) respectively.

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A Study on Cold Agglutinins in Malaria from a Tertiary Care Hospital of South India

Venkatesh V.N
Venkatesh V.N
Ravish Kumar M
Ravish Kumar M
Nagendra Gowda M. R
Nagendra Gowda M. R

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