Adaptogenic Activity of Morus Alba Extracts in Wistar Rats

1
Somayeh Afsah Vakili
Somayeh Afsah Vakili
2
Dr. Somayeh Afsah Vakili
Dr. Somayeh Afsah Vakili
3
Syed Fayazuddin
Syed Fayazuddin
1 Visveswarapura Institute of Pharmaceutical Sciences,

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Morus alba was broadly used with a long history of traditional medicinal remedy for the regimen of various illnesses. The current investigation was designed to evaluate anti-stress activity of aqueous and ethanol extracts of Morus alba. Anti-stress of aqueous and ethanol extracts of Morus alba was estimated by inducing stress in rats through the forceful swimming. Homovanillic acid (HVA), urinary vanillymandelic acid (VMA), 6-β-OH-cortisol, 5-hydroxyindoleacetic acid (5HIAA) and ascorbic acid were reckoned as non-invasive biomarkers to assess the adaptogenic activity. Daily oral administration of aqueous and ethanol extracts of Morus alba at dose of 200 and 400 mg/kg body weight one hour before the induction of stress to retard stress-induced urinary biochemical changes in a dose dependent manner. However, non-significant changes in the urinary excretion of Homovanillic acid (HVA), urinary vanillymandelic acid (VMA), 6-β-OH-cortisol, 5-hydroxyindoleacetic acid (5HIAA) and ascorbic acid was perceived when compared to basal levels in normal animals.

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

Somayeh Afsah Vakili. 2017. \u201cAdaptogenic Activity of Morus Alba Extracts in Wistar Rats\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 17 (GJMR Volume 17 Issue B3): .

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Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-B Classification: NLMC Code: QV 4
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v1.2

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November 3, 2017

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English

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Morus alba was broadly used with a long history of traditional medicinal remedy for the regimen of various illnesses. The current investigation was designed to evaluate anti-stress activity of aqueous and ethanol extracts of Morus alba. Anti-stress of aqueous and ethanol extracts of Morus alba was estimated by inducing stress in rats through the forceful swimming. Homovanillic acid (HVA), urinary vanillymandelic acid (VMA), 6-β-OH-cortisol, 5-hydroxyindoleacetic acid (5HIAA) and ascorbic acid were reckoned as non-invasive biomarkers to assess the adaptogenic activity. Daily oral administration of aqueous and ethanol extracts of Morus alba at dose of 200 and 400 mg/kg body weight one hour before the induction of stress to retard stress-induced urinary biochemical changes in a dose dependent manner. However, non-significant changes in the urinary excretion of Homovanillic acid (HVA), urinary vanillymandelic acid (VMA), 6-β-OH-cortisol, 5-hydroxyindoleacetic acid (5HIAA) and ascorbic acid was perceived when compared to basal levels in normal animals.

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Adaptogenic Activity of Morus Alba Extracts in Wistar Rats

Dr. Somayeh Afsah Vakili
Dr. Somayeh Afsah Vakili
Syed Fayazuddin
Syed Fayazuddin

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