Adaptogenic Activity of Morus Alba Extracts in Wistar Rats

Adaptogenic Activity of Morus Alba Extracts in Wistar Rats

Somayeh Afsah Vakili

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Syed Fayazuddin

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Rajiv Gandhi University of Health Sciences

Adaptogenic Activity of Morus Alba Extracts in Wistar Rats

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Abstract

Morus alba was broadly used with a long history of traditional medicinal remedy for the regimen of various illnesses. The current investigation was designed to evaluate anti-stress activity of aqueous and ethanol extracts of Morus alba. Anti-stress of aqueous and ethanol extracts of Morus alba was estimated by inducing stress in rats through the forceful swimming. Homovanillic acid (HVA), urinary vanillymandelic acid (VMA), 6-β-OH-cortisol, 5-hydroxyindoleacetic acid (5HIAA) and ascorbic acid were reckoned as non-invasive biomarkers to assess the adaptogenic activity. Daily oral administration of aqueous and ethanol extracts of Morus alba at dose of 200 and 400 mg/kg body weight one hour before the induction of stress to retard stress-induced urinary biochemical changes in a dose dependent manner. However, non-significant changes in the urinary excretion of Homovanillic acid (HVA), urinary vanillymandelic acid (VMA), 6-β-OH-cortisol, 5-hydroxyindoleacetic acid (5HIAA) and ascorbic acid was perceived when compared to basal levels in normal animals.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

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Not applicable for this article.

How to Cite This Article

Somayeh Afsah Vakili. 2017. \u201cAdaptogenic Activity of Morus Alba Extracts in Wistar Rats\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 17 (GJMR Volume 17 Issue B3).

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GJMR Volume 17 Issue B3

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-B Classification NLMC Code: QV 4

Submission ReceivedDecember 7, 2016
Peer Review Double Blind
Handling Editor
Accepted January 4, 2017
Published January 15, 2017

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v1.2

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November 3, 2017

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Article Matrices

Total Score: 107

Country: India

Subject: Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine

Authors: Dr. Somayeh Afsah Vakili, Syed Fayazuddin (PhD/Dr. count: 1)

View Count (all-time): 213

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Publish Date: 2017 11, Fri

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Total Views: 3369

Total Downloads: 1650

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