Additive Effect of Oral Tetradecanoic Acid to Tamsulosin and Finasteride in a Benign Prostatic Hyperplasia Rat Model

Additive Effect of Oral Tetradecanoic Acid to Tamsulosin and Finasteride in a Benign Prostatic Hyperplasia Rat Model

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Abstract

We investigated the benefit of the tetradecanoic acid combined with tamsulosin and finasteride, in a benign prostatic hyperplasia (BPH) rat model. By bilateral orchiectomy under ketamine anesthesia Castration was performed. A rat model of BPH was established by daily intramuscular administration of testosterone propionate plus 17 alpha-estradiol for 8 weeks. For 4 weeks from week 6 to 9 post-surgery model rats were administered combinations of 20 mg/kg of tetradecanoic acid, 0.01 mg/kg tamsulosin and 1 mg/kg finasteride once daily by oral gavage. Body and genitourinary organ weights were recorded, serums were assayed for hormone concentrations, and tissues were subjected to histopathology Combined tetradecanoic acid, tamsulosin, and finasteride significantly decreased prostatic index, serum hormone levels, epithelial thickness, The 3-drug combination was more effective than any other combination or tetradecanoic acid alone. These results suggest that tetradecanoic acid addition to tamsulosin and finasteride may be beneficial for the treatment of BPH patients who do not respond to tamsulosin plus finasteride.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Anup Patil, Dr. R.C. Doijad, Dr. P.V. Salve, A.A. Koparde. 2020. "Additive Effect of Oral Tetradecanoic Acid to Tamsulosin and Finasteride in a Benign Prostatic Hyperplasia Rat Model". Global Journal of Medical Research - F: Diseases GJMR-F Volume 20 (GJMR Volume 20 Issue F5).

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords
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GJMR-F Classification NLMC Code: WJ 752
  • Submission ReceivedDecember 16, 2019
  • Peer Review Double Blind
    Handling Editor
  • Accepted January 3, 2020
  • Published January 15, 2020
Version of record

v1.2

Issue date
May 9, 2020

Language
English
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Additive Effect of Oral Tetradecanoic Acid to Tamsulosin and Finasteride in a Benign Prostatic Hyperplasia Rat Model

Anup Patil
Anup Patil
Dr. Doijad
Dr. Doijad
Dr. Salve
Dr. Salve
A.A. Koparde
A.A. Koparde
  • Submission ReceivedDecember 16, 2019
  • Peer Review Double Blind
    Handling Editor
  • Accepted January 3, 2020
  • Published January 15, 2020