Neural Networks and Rules-based Systems used to Find Rational and Scientific Correlations between being Here and Now with Afterlife Conditions
Neural Networks and Rules-based Systems used to Find Rational and
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Atorvastatin is an antihyperlipidemic drug which is widely used to treat hyperlipidemia and lower the cholesterol level in the body, but atorvastatin has low bioavailability due to high intestinal clearance and first-pass metabolism. The main objective of our research work was to develop a formulation to increase the therapeutic efficacy of the drug. A bio-polymer was isolated from a natural edible source Coriandrum sativum and was subjected for screening its filmability and adhesivity. Atorvastatin was nanosized using a novel method and using the bio-polymer and other co-processing agents five bio-flexy films of different ratios (i.e. 1:1, 1:2, 1:3, 1:4, 1:5) were formulated. The isolated bio-polymer was subjected to various analytical parameters. The drug-excipient compatibility study was performed using UV and TLC method. The formulated bio-flexy films were evaluated for various parameters like weight, thickness, content uniformity, surface pH, folding endurance, and in-vitro drug permeation. The formulation AC2 (containing 1:2 bio-polymer) was found to be the best formulation having R 2 value 0.9989 with zero order as best fit model.
Kirti Singh. 2019. \u201cAn Innovative Gateway to Deliver Nanosized Atorvastatin by Bio-Flexy Film Approach\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 18 (GJMR Volume 18 Issue B5): .
Crossref Journal DOI 10.17406/gjmra
Print ISSN 0975-5888
e-ISSN 2249-4618
The methods for personal identification and authentication are no exception.
Total Score: 102
Country: India
Subject: Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine
Authors: Kirti Singh, N. V. Satheesh Madhav (PhD/Dr. count: 0)
View Count (all-time): 130
Total Views (Real + Logic): 2734
Total Downloads (simulated): 1452
Publish Date: 2019 01, Fri
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Atorvastatin is an antihyperlipidemic drug which is widely used to treat hyperlipidemia and lower the cholesterol level in the body, but atorvastatin has low bioavailability due to high intestinal clearance and first-pass metabolism. The main objective of our research work was to develop a formulation to increase the therapeutic efficacy of the drug. A bio-polymer was isolated from a natural edible source Coriandrum sativum and was subjected for screening its filmability and adhesivity. Atorvastatin was nanosized using a novel method and using the bio-polymer and other co-processing agents five bio-flexy films of different ratios (i.e. 1:1, 1:2, 1:3, 1:4, 1:5) were formulated. The isolated bio-polymer was subjected to various analytical parameters. The drug-excipient compatibility study was performed using UV and TLC method. The formulated bio-flexy films were evaluated for various parameters like weight, thickness, content uniformity, surface pH, folding endurance, and in-vitro drug permeation. The formulation AC2 (containing 1:2 bio-polymer) was found to be the best formulation having R 2 value 0.9989 with zero order as best fit model.
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