An Insight into the Genetic Study and Pathogenesis of the Colorectal Cancer

α
Tapan Behl
Tapan Behl
σ
Ishneet Kaur
Ishneet Kaur
ρ
Heena Goel
Heena Goel
Ѡ
Rajesh K. Pandey
Rajesh K. Pandey
α University of Delhi University of Delhi

Send Message

To: Author

An Insight into the Genetic Study and Pathogenesis of the Colorectal Cancer

Article Fingerprint

ReserarchID

PDDTM6156Z

An Insight into the Genetic Study and Pathogenesis of the Colorectal Cancer Banner

AI TAKEAWAY

Connecting with the Eternal Ground
  • English
  • Afrikaans
  • Albanian
  • Amharic
  • Arabic
  • Armenian
  • Azerbaijani
  • Basque
  • Belarusian
  • Bengali
  • Bosnian
  • Bulgarian
  • Catalan
  • Cebuano
  • Chichewa
  • Chinese (Simplified)
  • Chinese (Traditional)
  • Corsican
  • Croatian
  • Czech
  • Danish
  • Dutch
  • Esperanto
  • Estonian
  • Filipino
  • Finnish
  • French
  • Frisian
  • Galician
  • Georgian
  • German
  • Greek
  • Gujarati
  • Haitian Creole
  • Hausa
  • Hawaiian
  • Hebrew
  • Hindi
  • Hmong
  • Hungarian
  • Icelandic
  • Igbo
  • Indonesian
  • Irish
  • Italian
  • Japanese
  • Javanese
  • Kannada
  • Kazakh
  • Khmer
  • Korean
  • Kurdish (Kurmanji)
  • Kyrgyz
  • Lao
  • Latin
  • Latvian
  • Lithuanian
  • Luxembourgish
  • Macedonian
  • Malagasy
  • Malay
  • Malayalam
  • Maltese
  • Maori
  • Marathi
  • Mongolian
  • Myanmar (Burmese)
  • Nepali
  • Norwegian
  • Pashto
  • Persian
  • Polish
  • Portuguese
  • Punjabi
  • Romanian
  • Russian
  • Samoan
  • Scots Gaelic
  • Serbian
  • Sesotho
  • Shona
  • Sindhi
  • Sinhala
  • Slovak
  • Slovenian
  • Somali
  • Spanish
  • Sundanese
  • Swahili
  • Swedish
  • Tajik
  • Tamil
  • Telugu
  • Thai
  • Turkish
  • Ukrainian
  • Urdu
  • Uzbek
  • Vietnamese
  • Welsh
  • Xhosa
  • Yiddish
  • Yoruba
  • Zulu

Abstract

Colorectal cancer is defined as the cancer of the large intestine or the rectum -thus attributing to some other names related to this cancer such as -bowel cancer or rectal cancer, depending on the site where the tumor has occurred. It mostly begins as a benign tumor with then turns into a carcinoma.Colon cancer and rectal cancer are related in terms of their genetics and thus are studied together as allied tumors. Although some other factors such as age and lifestyle are also concerned with the progression of this cancer, a minority group of people acquire it because of certain genetic predisposition, which is focused upon in this review. Initially it was thought only to occur because of certain mutations in a specific gene called adenomatous polyposis coli (APC) gene which are responsible for initiating the characteristic events which lead to the progression of this tumor.The cases affected by this pathway were called the LOH group. But further researches concluded that there is another different pathway which can lead to the occurrence of this tumor apart from the one briefly stated above.

References

46 Cites in Article
  1. S Landis,T Murray,S Bolden,P Wingo (1999). Cancer statistics, 1999.
  2. F Berrino,R De Angelis,M Sant (2007). Survival for eight major cancers and all cancers combined for European adults diagnosed in 1995-99: results of the EUROCARE-4 study.
  3. Rebecca Siegel,Jiemin Ma,Zhaohui Zou,Ahmedin Jemal (2014). Cancer statistics, 2014.
  4. N Becker (2003). Epidemiology of colorectal cancer.
  5. F Jemal,M Bray,Center (2011). Global cancer statistics.
  6. S Majumdar,R Fletcher,A Evans (1999). How does colorectal cancer present? Symptoms, duration, and clues to location.
  7. Robert Fletcher (2009). The diagnosis of colorectal cancer in patients with symptoms: finding a needle in a haystack.
  8. K Bielecki,P Kamiński,M Klukowski (2002). Large bowel perforation: morbidity and mortality.
  9. L Bianchi,C Burke (2008). Understanding current guidelines for colorectal cancer screening: A case-based approach.
  10. D Alexander,C Cushing (2011). Red meat and colorectal cancer: a critical summary of prospective epidemiologic studies.
  11. M Boutron,M Wilpart,J Faivre (1991). Diet and colorectal cancer.
  12. E Giovannucci (2001). An Updated Review of the Epidemiological Evidence that Cigarette Smoking Increases Risk of Colorectal Cancer.
  13. Nils Homann,Jyrki Tillonen,Mikko Salaspuro (2000). Microbially produced acetaldehyde from ethanol may increase the risk of colon cancer via folate deficiency.
  14. A Wu,A Paganini-Hill,R Ross,B Henderson (1987). Alcohol, physical activity and other risk factors for colorectal cancer: A prospective study.
  15. Elizabeth Half,Dani Bercovich,Paul Rozen (2009). Familial adenomatous polyposis.
  16. S Dolwani,S Jones,D Eccles (2003). Autosomal recessive colorectal adenomatous polyposis due to inherited mutations of MYH.
  17. Robert Gryfe (2009). Inherited Colorectal Cancer Syndromes.
  18. Franc¸oise Piard,Laurent Martin,Caroline Chapusot,Tibor Ponnelle,Jean Faivre (2002). Lésions planes précurseurs du cancer colorectal.
  19. Patrice Morin,Andrew Sparks,Vladimir Korinek,Nick Barker,Hans Clevers,Bert Vogelstein,Kenneth Kinzler (1997). Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC.
  20. Li‐hua Jin,Qiu‐jie Shao,Wen Luo,Zhi‐yun Ye,Qing Li,Sheng‐cai Lin (2003). Detection of point mutations of the Axin1 gene in colorectal cancers.
  21. W Liu,M Dong,Mai (2000). Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signaling.
  22. Pantelis Hatzis,Laurens Van Der Flier,Marc Van Driel,Victor Guryev,Fiona Nielsen,Sergei Denissov,Isaäc Nijman,Jan Koster,Evan Santo,Willem Welboren,Rogier Versteeg,Edwin Cuppen,Marc Van De Wetering,Hans Clevers,Hendrik Stunnenberg (2008). Genome-Wide Pattern of TCF7L2/TCF4 Chromatin Occupancy in Colorectal Cancer Cells.
  23. Jianhui Guo,Tolga Cagatay,Guangjin Zhou,Chih-Chiang Chan,Shelby Blythe,Kaye Suyama,Li Zheng,Kaifeng Pan,Chiping Qian,Richard Hamelin,Stephen Thibodeau,Peter Klein,Keith Wharton,Wanguo Liu (2009). Mutations in the Human naked cuticle Homolog NKD1 Found in Colorectal Cancer Alter Wnt/Dvl/β-Catenin Signaling.
  24. S Libutti,L Saltz,J Tepper,Devita (2008). Hellman, and Rosenberg's cancer: principles and practice of oncology.
  25. Carolyn Compton,Ernie Hawk,Louise Grochow,Fred Lee,Mark Ritter,John Niederhuber (2008). Colon Cancer.
  26. Sanford Markowitz,Dawn Dawson,Joseph Willis,James Willson (2002). Focus on colon cancer.
  27. Thierry André,Corrado Boni,Lamia Mounedji-Boudiaf,Matilde Navarro,Josep Tabernero,Tamas Hickish,Clare Topham,Marta Zaninelli,Philip Clingan,John Bridgewater,Isabelle Tabah-Fisch,Aimery De Gramont (2004). Oxaliplatin, Fluorouracil, and Leucovorin as Adjuvant Treatment for Colon Cancer.
  28. Vladimir Korinek,Nick Barker,Patrice Morin,Dick Van Wichen,Roel De Weger,Kenneth Kinzler,Bert Vogelstein,Hans Clevers (1997). Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC <sup>−/−</sup> Colon Carcinoma.
  29. Kathleen Goss,Joanna Groden (2000). Biology of the Adenomatous Polyposis Coli Tumor Suppressor.
  30. Mary Prieve,Marian Waterman (1999). Nuclear Localization and Formation of β-Catenin–Lymphoid Enhancer Factor 1 Complexes Are Not Sufficient for Activation of Gene Expression.
  31. K Kinzler,B Vogelstein (2002). Colorectal tumors. In: The genetic basis of human cancer.
  32. Arnold Levine (1997). p53, the Cellular Gatekeeper for Growth and Division.
  33. Suzanne Baker,Eric Fearon,Janice Nigro,Stanley Hamilton,Ann Preisinger,J Jessup,Peter Vantuinen,David Ledbetter,David Barker,Yusuke Nakamura,Ray White,Bert Vogelstein (1989). Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas.
  34. S Baker,A Preisinger,J Jessup (1990). p53 Gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis.
  35. Gregory Riggins,Sam Thiagalingam,Ester Rozenblum,Craig Weinstein,Scott Kern,Stanley Hamilton,James Willson,Sanford Markowitz,Kenneth Kinzler,Bert Vogelstein (1996). Mad-related genes in the human.
  36. J Fang,B Richardson (2005). The MAPK signaling pathways and colorectal cancer.
  37. Johannes Bos,Eric Fearon,Stanley Hamilton,Matty Vries,Jacques Van Boom,Alex Van Der Eb,Bert Vogelstein (1987). Prevalence of ras gene mutations in human colorectal cancers.
  38. Michael O'brien (2007). Hyperplastic and Serrated Polyps of the Colorectum.
  39. H Davies,G Bignell,C Cox (2002). Mutations of the BRAF gene in human cancer.
  40. Yardena Samuels,Zhenghe Wang,Alberto Bardelli,Natalie Silliman,Janine Ptak,Steve Szabo,Hai Yan,Adi Gazdar,Steven Powell,Gregory Riggins,James Willson,Sanford Markowitz,Kenneth Kinzler,Bert Vogelstein,Victor Velculescu (2004). High Frequency of Mutations of the <i>PIK3CA</i> Gene in Human Cancers.
  41. D Parsons,T Wang,Y Samuels (2005). Colorectal cancer: mutations in a signalling pathway.
  42. Siân Jones,Wei-Dong Chen,Giovanni Parmigiani,Frank Diehl,Niko Beerenwinkel,Tibor Antal,Arne Traulsen,Martin Nowak,Christopher Siegel,Victor Velculescu,Kenneth Kinzler,Bert Vogelstein,Joseph Willis,Sanford Markowitz (2008). Comparative lesion sequencing provides insights into tumor evolution.
  43. Min Yan,Ronald Rerko,Petra Platzer,Dawn Dawson,Joseph Willis,Min Tong,Earl Lawrence,James Lutterbaugh,Shilong Lu,James Willson,Guangbin Luo,Jack Hensold,Hsin-Hsiung Tai,Keith Wilson,Sanford Markowitz (2004). 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-β-induced suppressor of human gastrointestinal cancers.
  44. Gideon Steinbach,Patrick Lynch,Robin Phillips,Marina Wallace,Ernest Hawk,Gary Gordon,Naoki Wakabayashi,Brian Saunders,Yu Shen,Takashi Fujimura,Li-Kuo Su,Bernard Levin,Louis Godio,Sherri Patterson,Miguel Rodriguez-Bigas,Susan Jester,Karen King,Marta Schumacher,James Abbruzzese,Raymond Dubois,Walter Hittelman,Stuart Zimmerman,Jeffrey Sherman,Gary Kelloff (2000). The Effect of Celecoxib, a Cyclooxygenase-2 Inhibitor, in Familial Adenomatous Polyposis.
  45. Leonard Saltz,Neal Meropol,Patrick Loehrer,Michael Needle,Justin Kopit,Robert Mayer (2004). Phase II Trial of Cetuximab in Patients With Refractory Colorectal Cancer That Expresses the Epidermal Growth Factor Receptor.
  46. Minaxi Jhawer,Sanjay Goel,Andrew Wilson,Cristina Montagna,Yi-He Ling,Do-Sun Byun,Shannon Nasser,Diego Arango,Joongho Shin,Lidija Klampfer,Leonard Augenlicht,Roman Soler,John Mariadason (2023). Data from PIK3CA Mutation/PTEN Expression Status Predicts Response of Colon Cancer Cells to the Epidermal Growth Factor Receptor Inhibitor Cetuximab.

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Tapan Behl. 2014. \u201cAn Insight into the Genetic Study and Pathogenesis of the Colorectal Cancer\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 14 (GJMR Volume 14 Issue B4): .

Download Citation

Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Version of record

v1.2

Issue date

September 4, 2014

Language
en
Experiance in AR

Explore published articles in an immersive Augmented Reality environment. Our platform converts research papers into interactive 3D books, allowing readers to view and interact with content using AR and VR compatible devices.

Read in 3D

Your published article is automatically converted into a realistic 3D book. Flip through pages and read research papers in a more engaging and interactive format.

Article Matrices
Total Views: 4600
Total Downloads: 2242
2026 Trends
Related Research

Published Article

Colorectal cancer is defined as the cancer of the large intestine or the rectum -thus attributing to some other names related to this cancer such as -bowel cancer or rectal cancer, depending on the site where the tumor has occurred. It mostly begins as a benign tumor with then turns into a carcinoma.Colon cancer and rectal cancer are related in terms of their genetics and thus are studied together as allied tumors. Although some other factors such as age and lifestyle are also concerned with the progression of this cancer, a minority group of people acquire it because of certain genetic predisposition, which is focused upon in this review. Initially it was thought only to occur because of certain mutations in a specific gene called adenomatous polyposis coli (APC) gene which are responsible for initiating the characteristic events which lead to the progression of this tumor.The cases affected by this pathway were called the LOH group. But further researches concluded that there is another different pathway which can lead to the occurrence of this tumor apart from the one briefly stated above.

Our website is actively being updated, and changes may occur frequently. Please clear your browser cache if needed. For feedback or error reporting, please email [email protected]

Request Access

Please fill out the form below to request access to this research paper. Your request will be reviewed by the editorial or author team.
X

Quote and Order Details

Contact Person

Invoice Address

Notes or Comments

This is the heading

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Ut elit tellus, luctus nec ullamcorper mattis, pulvinar dapibus leo.

High-quality academic research articles on global topics and journals.

An Insight into the Genetic Study and Pathogenesis of the Colorectal Cancer

Tapan Behl
Tapan Behl University of Delhi
Ishneet Kaur
Ishneet Kaur
Heena Goel
Heena Goel
Rajesh K. Pandey
Rajesh K. Pandey

Research Journals