An Insight into the Genetic Study and Pathogenesis of the Colorectal Cancer

1
Tapan Behl
Tapan Behl
2
Ishneet Kaur
Ishneet Kaur
3
Heena Goel
Heena Goel
4
Rajesh K. Pandey
Rajesh K. Pandey
1 Delhi University

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An Insight into the Genetic Study and Pathogenesis of the Colorectal Cancer Banner
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Colorectal cancer is defined as the cancer of the large intestine or the rectum -thus attributing to some other names related to this cancer such as -bowel cancer or rectal cancer, depending on the site where the tumor has occurred. It mostly begins as a benign tumor with then turns into a carcinoma.Colon cancer and rectal cancer are related in terms of their genetics and thus are studied together as allied tumors. Although some other factors such as age and lifestyle are also concerned with the progression of this cancer, a minority group of people acquire it because of certain genetic predisposition, which is focused upon in this review. Initially it was thought only to occur because of certain mutations in a specific gene called adenomatous polyposis coli (APC) gene which are responsible for initiating the characteristic events which lead to the progression of this tumor.The cases affected by this pathway were called the LOH group. But further researches concluded that there is another different pathway which can lead to the occurrence of this tumor apart from the one briefly stated above.

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No external funding was declared for this work.

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The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

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Not applicable for this article.

Tapan Behl. 2014. \u201cAn Insight into the Genetic Study and Pathogenesis of the Colorectal Cancer\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 14 (GJMR Volume 14 Issue B4): .

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Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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September 4, 2014

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English

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Colorectal cancer is defined as the cancer of the large intestine or the rectum -thus attributing to some other names related to this cancer such as -bowel cancer or rectal cancer, depending on the site where the tumor has occurred. It mostly begins as a benign tumor with then turns into a carcinoma.Colon cancer and rectal cancer are related in terms of their genetics and thus are studied together as allied tumors. Although some other factors such as age and lifestyle are also concerned with the progression of this cancer, a minority group of people acquire it because of certain genetic predisposition, which is focused upon in this review. Initially it was thought only to occur because of certain mutations in a specific gene called adenomatous polyposis coli (APC) gene which are responsible for initiating the characteristic events which lead to the progression of this tumor.The cases affected by this pathway were called the LOH group. But further researches concluded that there is another different pathway which can lead to the occurrence of this tumor apart from the one briefly stated above.

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An Insight into the Genetic Study and Pathogenesis of the Colorectal Cancer

Tapan Behl
Tapan Behl Delhi University
Ishneet Kaur
Ishneet Kaur
Heena Goel
Heena Goel
Rajesh K. Pandey
Rajesh K. Pandey

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