Analysis by GC-MS of an Aza-Michael Reaction Catalyzed by CALB on an Orbital Shaker and under Microwave Irradiation

Analysis by GC-MS of an Aza-Michael Reaction Catalyzed by CALB on an Orbital Shaker and under Microwave Irradiation

Andr L. M. Porto

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Sandra S. Ribeiro

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Marciana P. Uliana

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Timothy J. Brocksom

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Universidade de São Paulo

Analysis by GC-MS of an Aza-Michael Reaction Catalyzed by CALB on an Orbital Shaker and under Microwave Irradiation

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Abstract

In this study, aza-Michael reactions between 1-phenylmethanamine and α,β-unsaturated cyclohexenones were investigated, using lipase from Candida antarctica. The reactions were performed in various organic solvents (CH 2 Cl 2 , hexane, MeOH, toluene, THF) under mild conditions, with orbital shaking and microwave irradiation. The reactions showed good results in the presence of CALB, yielding the Michael adducts and imines. The reaction products were analyzed by GC-MS and in some cases it was found that the reverse aza-Michael reaction had occurred.

References

29 Cites in Article

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

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How to Cite This Article

Andr L. M. Porto. 2014. \u201cAnalysis by GC-MS of an Aza-Michael Reaction Catalyzed by CALB on an Orbital Shaker and under Microwave Irradiation\u201d. Global Journal of Science Frontier Research - B: Chemistry GJSFR-B Volume 14 (GJSFR Volume 14 Issue B1): .

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GJSFR Volume 14 Issue B1
Pg. 7- 21

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Journal Specifications

Crossref Journal DOI 10.17406/GJSFR

Print ISSN 0975-5896

e-ISSN 2249-4626

Keywords

amines aza-michael addition biocatalysis enones imines

Submission ReceivedJanuary 24, 2014
Peer Review Double Blind
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Accepted February 13, 2014
Published February 28, 2014

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March 7, 2014

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Article Matrices

Total Score: 104

Country: Brazil

Subject: Global Journal of Science Frontier Research - B: Chemistry

Authors: Sandra S. Ribeiro, Marciana P. Uliana, Timothy J. Brocksom, Andr L. M. Porto (PhD/Dr. count: 0)

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