Antagonist Effect of Theophylline and Caffeine on Some Transaminase Enzymes Activities

Article ID

IO84Y

Antagonist Effect of Theophylline and Caffeine on Some Transaminase Enzymes Activities

Dr. Salma Abdul Rudha Abbass
Dr. Salma Abdul Rudha Abbass AL-Mustansiriyah university, college of science, department of chemistry
Manal Sadeq Hammoodi
Manal Sadeq Hammoodi
Wafa Raji Mohammed
Wafa Raji Mohammed
Amer Hasan Abdullah
Amer Hasan Abdullah
DOI

Abstract

The purpose of this study is to show the effect of caffeine and theophylline on the activities of aspartate aminotransferase AST and alanine aminotransferase ALT, in the human sera. Serum AST and ALT were activated by caffeine, while inhibiting by theophylline, this effect increased with increasing the concentration of theophylline and caffeine. Kinetic properties of AST and ALT activities revealed by theophylline and that non-competitive inhibition type, and non-competitive activation by caffeine.

Antagonist Effect of Theophylline and Caffeine on Some Transaminase Enzymes Activities

The purpose of this study is to show the effect of caffeine and theophylline on the activities of aspartate aminotransferase AST and alanine aminotransferase ALT, in the human sera. Serum AST and ALT were activated by caffeine, while inhibiting by theophylline, this effect increased with increasing the concentration of theophylline and caffeine. Kinetic properties of AST and ALT activities revealed by theophylline and that non-competitive inhibition type, and non-competitive activation by caffeine.

Dr. Salma Abdul Rudha Abbass
Dr. Salma Abdul Rudha Abbass AL-Mustansiriyah university, college of science, department of chemistry
Manal Sadeq Hammoodi
Manal Sadeq Hammoodi
Wafa Raji Mohammed
Wafa Raji Mohammed
Amer Hasan Abdullah
Amer Hasan Abdullah

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Dr. Salma Abdul Rudha Abbass. 2013. “. Global Journal of Science Frontier Research – B: Chemistry GJSFR-B Volume 13 (GJSFR Volume 13 Issue B3): .

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Crossref Journal DOI 10.17406/GJSFR

Print ISSN 0975-5896

e-ISSN 2249-4626

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GJSFR Volume 13 Issue B3
Pg. 29- 27
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Antagonist Effect of Theophylline and Caffeine on Some Transaminase Enzymes Activities

Dr. Salma Abdul Rudha Abbass
Dr. Salma Abdul Rudha Abbass AL-Mustansiriyah university, college of science, department of chemistry
Manal Sadeq Hammoodi
Manal Sadeq Hammoodi
Wafa Raji Mohammed
Wafa Raji Mohammed
Amer Hasan Abdullah
Amer Hasan Abdullah

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