Anti Biofilm Effect of Biogenic Silver Nanoparticles Coated Medical Devices Against Biofilm of Clinical Isolate of Staphylococcus Aureus

karthi namachu

Anti Biofilm Effect of Biogenic Silver Nanoparticles Coated Medical Devices Against Biofilm of Clinical Isolate of Staphylococcus Aureus

karthi namachu * §

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§ Sathyabama University

Anti Biofilm Effect of Biogenic Silver Nanoparticles Coated Medical Devices Against Biofilm of Clinical Isolate of Staphylococcus Aureus

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Abstract

Biofilm represents the most prevalent type of virulent factor of most of the pathogenic microorganism and involved in crucial development of clinical infection and exhibit resistance to antimicrobial agents. Now the biofilm is considered as major target for the pharmacological development of drugs. A biofilm serves to promote bacteria persistence by resisting antibiotic treatment and host immune responses. Antibiotics are rendered ineffective when biofilms form due to their relative impermeability, the variable physiological status of microorganisms, subpopulations of persistent strains, and variations of phenotypes present. Metal nanotechnology chemistry has the potential to prevent the formation of these life-threatening biofilms on life supporting devices. In the present study, anti biofilm effect of silver nanoparticles coated catheter against clinical isolate of Staphylococcus Aureus was studied. Silver nanoparticles synthesized by leaf extract broth of Azadirhacta indica were coated on the catheter chara-cterized by scanning electron microscopy which reveals complete dispersion of the nanoparticles on the fibre surface of the catheter and the size, shape of the particles shows uniform spherical particles with the size of 50-60 nm. Distinct effect of biofilm inhibition was recorded in the nanoparticles coated catheter and maximum inhibition was observed during 72 hour of incubation. Biochemical composition of biofilm matrix mainly total carbohydrates and total protein was highly reduced. The present study would suggests the development of anti microbial coated medical devices against pathogenic microorganism.

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11 Cites in Article

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

karthi namachu. 2013. "Anti Biofilm Effect of Biogenic Silver Nanoparticles Coated Medical Devices Against Biofilm of Clinical Isolate of Staphylococcus Aureus". Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 13 (GJMR Volume 13 Issue B3).

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GJMR Volume 13 Issue B3

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

biofilm biogenic silver nanoparticles catheter

Classification

GJMR-B Classification NLMC Code: QY 21

QW 90

Submission ReceivedDecember 11, 2012
Peer Review Double Blind
Handling Editor
Accepted December 31, 2012
Published January 15, 2013

Version of record

v1.2

Issue date

June 24, 2013

Language

English

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Article Matrices

Total Score: 145

Country: India

Subject: Global Journal of Medical Research

Authors: S.Karthick Raja Namasivayam, Beninton.B.Christo, S.M.Karthigai Arasu, K.Arun Muthu Kumar, K.Deepak (PhD/Dr. count: 0)

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