Anti-Cancer Activities of Cu(?) Ion Solution in Progression  and Development against Cancer and Tumor Cells

Anti-Cancer Activities of Cu(?) Ion Solution in Progression and Development against Cancer and Tumor Cells

D. Sc Tsuneo Ishida

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Anti-Cancer Activities of Cu(?) Ion Solution in Progression and Development against Cancer and Tumor Cells

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Abstract

Copper plays important role of cancer cell progression and development, malignant cell growth, and angiogenesis in invasive and metastatic growths. Specially, angiogenesis and autophagy have been worthy of new blood vessel formations and fusion proteins respectively for malignant and tumor cell growths. Schiff base copper(Ⅱ) complexes have anti-proliferative activity against cancer cells. Cu 2+ ions play an important role as pro-cancer factor in tumor tissues especially in tumor angiogenesis, invasion, and metastasis.Specially, Cu 2+ ions as Cu-chelating complex can inhibit formation of new blood vessel of tumor cell against angiogenesis in cancer.Promotion and development of cancer tissues have been proceeding with homeostatic imbalances of copper, in which can be caused by the uptake of excessive amounts of copper and some genetic defects.Cancer cell killing via ROS that superoxide anion O 2 -, hydroxyl radical ･OH, hydrogen peroxide H 2 O 2 mainly may be performed under cellular Cu 2+ ions induced ROS generations in tumor cells. Finally, Cu 2+ -H 2 O 2 induced DNA base-pairs inhibition can be regarded as being undergone to DNA damages due to Cu 2+ -complex formations within DNA base-pairs G≡C, A=T by Cu 2+ substitutions in hydrogen bonds of DNA base-pairs.

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The authors declare no conflict of interest.

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How to Cite This Article

D. Sc Tsuneo Ishida. 2017. \u201cAnti-Cancer Activities of Cu(?) Ion Solution in Progression and Development against Cancer and Tumor Cells\u201d. Global Journal of Medical Research - K: Interdisciplinary GJMR-K Volume 17 (GJMR Volume 17 Issue K6).

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GJMR Volume 17 Issue K6

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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NLMC Code QZ 206

Submission ReceivedDecember 14, 2016
Peer Review Double Blind
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Accepted January 1, 2017
Published January 15, 2017

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December 23, 2017

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Total Score: 146

Country: Japan

Subject: Global Journal of Medical Research - K: Interdisciplinary

Authors: D. Sc Tsuneo Ishida (PhD/Dr. count: 0)

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