Antidepressant and Anti-Inflammatory Activities of Cationic Amphiphilic Complexes of Sulphadiazine

Antidepressant and Anti-Inflammatory Activities of Cationic Amphiphilic Complexes of Sulphadiazine

K.Hariprasath

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I. Sudheer babu

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P.Venkatesh

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U.Upendra Rao.

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Jawaharlal Nehru Technological University, Kakinada

Antidepressant and Anti-Inflammatory Activities of Cationic Amphiphilic Complexes of Sulphadiazine

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Abstract

In our study we synthesized schiff’ base of sulphadiazine on treating with aromatic aldehydes like para diethyl amino benzyldehyde and paradimethyl amino benzyldehyde. The synthesized schiff’s bases were converted to its cationic amphiphilic bases by treating with methyl iodide. The cationic schiff bases were converted to metal complexes by treating with metals like copper chloride (CuCl2), zinc chloride (ZnCl2) and cadmium chloride (CdCl2). All the synthesized compounds were characterized by elemental analysis, IR and H1 NMR. Synthesized compounds were screened for anti-inflammatory and antidepressant activity. Copper metal complexes showed excellent anti-inflammatory activity and zinc metal complexes showed excellent anti-depressant activity.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

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How to Cite This Article

K.Hariprasath. 2015. \u201cAntidepressant and Anti-Inflammatory Activities of Cationic Amphiphilic Complexes of Sulphadiazine\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 14 (GJMR Volume 14 Issue B7): .

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GJMR Volume 14 Issue B7
Pg. 9- 16

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

anti-inflammatory and antidepressant activity cationic amphiphilic bases metal complexes Schiff base

Submission ReceivedDecember 11, 2013
Peer Review Double Blind
Handling Editor
Accepted January 4, 2014
Published January 15, 2014

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Issue date

January 19, 2015

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Article Matrices

Total Score: 104

Country: India

Subject: Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine

Authors: K.Hariprasath, I. Sudheer babu, P.Venkatesh, U.Upendra Rao. (PhD/Dr. count: 0)

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Total Downloads: 2292

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