Antidepressant and Anti-Inflammatory Activities of Cationic Amphiphilic Complexes of Sulphadiazine

1
K.Hariprasath
K.Hariprasath
2
I. Sudheer babu
I. Sudheer babu
3
P.Venkatesh
P.Venkatesh
4
U.Upendra Rao.
U.Upendra Rao.
1 Adarsa College of Pharmacy

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In our study we synthesized schiff’ base of sulphadiazine on treating with aromatic aldehydes like para diethyl amino benzyldehyde and paradimethyl amino benzyldehyde. The synthesized schiff’s bases were converted to its cationic amphiphilic bases by treating with methyl iodide. The cationic schiff bases were converted to metal complexes by treating with metals like copper chloride (CuCl2), zinc chloride (ZnCl2) and cadmium chloride (CdCl2). All the synthesized compounds were characterized by elemental analysis, IR and H1 NMR. Synthesized compounds were screened for anti-inflammatory and antidepressant activity. Copper metal complexes showed excellent anti-inflammatory activity and zinc metal complexes showed excellent anti-depressant activity.

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No external funding was declared for this work.

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The authors declare no conflict of interest.

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K.Hariprasath. 2015. \u201cAntidepressant and Anti-Inflammatory Activities of Cationic Amphiphilic Complexes of Sulphadiazine\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 14 (GJMR Volume 14 Issue B7): .

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Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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January 19, 2015

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English

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In our study we synthesized schiff’ base of sulphadiazine on treating with aromatic aldehydes like para diethyl amino benzyldehyde and paradimethyl amino benzyldehyde. The synthesized schiff’s bases were converted to its cationic amphiphilic bases by treating with methyl iodide. The cationic schiff bases were converted to metal complexes by treating with metals like copper chloride (CuCl2), zinc chloride (ZnCl2) and cadmium chloride (CdCl2). All the synthesized compounds were characterized by elemental analysis, IR and H1 NMR. Synthesized compounds were screened for anti-inflammatory and antidepressant activity. Copper metal complexes showed excellent anti-inflammatory activity and zinc metal complexes showed excellent anti-depressant activity.

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Antidepressant and Anti-Inflammatory Activities of Cationic Amphiphilic Complexes of Sulphadiazine

K.Hariprasath
K.Hariprasath Adarsa College of Pharmacy
I. Sudheer babu
I. Sudheer babu
P.Venkatesh
P.Venkatesh
U.Upendra Rao.
U.Upendra Rao.

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