Antidepressant and Anti-Inflammatory Activities of Cationic Amphiphilic Complexes of Sulphadiazine

K.Hariprasath; I. Sudheer babu; P.Venkatesh

Antidepressant and Anti-Inflammatory Activities of Cationic Amphiphilic Complexes of Sulphadiazine

K.Hariprasath * §

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I. Sudheer babu §

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P.Venkatesh §

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uupendrarao §

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§ Adarsa College of Pharmacy

Antidepressant and Anti-Inflammatory Activities of Cationic Amphiphilic Complexes of Sulphadiazine

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Abstract

In our study we synthesized schiff’ base of sulphadiazine on treating with aromatic aldehydes like para diethyl amino benzyldehyde and paradimethyl amino benzyldehyde. The synthesized schiff’s bases were converted to its cationic amphiphilic bases by treating with methyl iodide. The cationic schiff bases were converted to metal complexes by treating with metals like copper chloride (CuCl2), zinc chloride (ZnCl2) and cadmium chloride (CdCl2). All the synthesized compounds were characterized by elemental analysis, IR and H1 NMR. Synthesized compounds were screened for anti-inflammatory and antidepressant activity. Copper metal complexes showed excellent anti-inflammatory activity and zinc metal complexes showed excellent anti-depressant activity.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

K.Hariprasath, I. Sudheer babu, P.Venkatesh, uupendrarao. 2015. "Antidepressant and Anti-Inflammatory Activities of Cationic Amphiphilic Complexes of Sulphadiazine". Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 14 (GJMR Volume 14 Issue 56 (B7)).

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GJMR Volume 14 Issue 56 (B7)

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

anti-inflammatory and antidepressant activity cationic amphiphilic bases metal complexes Schiff base

Classification

GJMR-B Classification NLMC Code: QV 37.5

Submission ReceivedDecember 11, 2013
Peer Review Double Blind
Handling Editor
Accepted January 4, 2014
Published November 27, 2014

Version of record

v1.2

Issue date

November 27, 2014

Language

English

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Article Matrices

Total Score: 104

Country: India

Subject: Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine

Authors: K.Hariprasath, I. Sudheer babu, P.Venkatesh, U.Upendra Rao. (PhD/Dr. count: 0)

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