Antidepressant and Anti-Inflammatory Activities of Cationic Amphiphilic Complexes of Sulphadiazine

K.Hariprasath; I. Sudheer babu; P.Venkatesh

Antidepressant and Anti-Inflammatory Activities of Cationic Amphiphilic Complexes of Sulphadiazine

K.Hariprasath * §

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I. Sudheer babu

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P.Venkatesh

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uupendrarao

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§ Adarsa College of Pharmacy

Antidepressant and Anti-Inflammatory Activities of Cationic Amphiphilic Complexes of Sulphadiazine

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Abstract

In our study we synthesized schiff’ base of sulphadiazine on treating with aromatic aldehydes like para diethyl amino benzyldehyde and paradimethyl amino benzyldehyde. The synthesized schiff’s bases were converted to its cationic amphiphilic bases by treating with methyl iodide. The cationic schiff bases were converted to metal complexes by treating with metals like copper chloride (CuCl2), zinc chloride (ZnCl2) and cadmium chloride (CdCl2). All the synthesized compounds were characterized by elemental analysis, IR and H1 NMR. Synthesized compounds were screened for anti-inflammatory and antidepressant activity. Copper metal complexes showed excellent anti-inflammatory activity and zinc metal complexes showed excellent anti-depressant activity.

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20 Cites in Article

Reference Format

M Tyszka-Czochara,A Grzywacz,G Gdula-Argasi,S Librowski,Wili Ski,B Opoka,W (2014). The Role of Zinc in the Pathogenesis and Treatment of Central Nervous System diseases. Implications of zinc Homeostasis for proper CNS Function.
M Banerjee,A Azam,S Sahu (2009). Synthesis, Characterization and Biological Evaluation of Schiff'sbase Transition Metal Complexes with Celecoxib and Sulfomethoxazole.
Lei Shi,Hui-Ming Ge,Shu-Hua Tan,Huan-Qiu Li,Yong-Chun Song,Hai-Liang Zhu,Ren-Xiang Tan (2007). Synthesis and antimicrobial activities of Schiff bases derived from 5-chloro-salicylaldehyde.
P Panneerselvam,R Nair,G Vijayalakshmi,E Subramanian,S Sridhar (2005). Synthesis of Schiff bases of 4-(4-aminophenyl)-morpholine as potential antimicrobial agents.
N Negm,M Zaki,M Salem (2010). Cationic schiff base amphiphiles and their metal complexes: Surface and biocidal activities against bacteria and fungi.
Ibotomba Singh,U,Bhubon Singha,R,Radhapiyari Devib,W,Brajakisor Singh,Ch (2012). Schiff base complexes of Copper (II) ions : Synthesis, Characterization and Antimicrobial studies.
D Ajaykumar,L Kulkarni,A Sangamesh,L Patil,S Prema,S Badami (2009). Electrochemical Properties of some Transition Metal Complexes: Synthesis, Characterization and Invitroantimicrobial studies of Co(II), Ni(II), Cu(II), Mn(II) and Fe(III) Complexes.
(2000). Test No. 423: Acute Oral toxicity - Acute Toxic Class Method.
S Kulkarni (2010). Handbook of experimental pharmacology.
B Sathe,E Jaychandran,G Sreenivasa,V Jagtap (2011). Antimycobacterial Activity of Some Synthesized Fluorinated Benzothiazolo Imidazole Compounds.
Danyi Wei,Ning Li,Gui Lu,Kemin Yao (2006). Synthesis, catalytic and biological activity of novel dinuclear copper complex with Schiff base.
K Venugopala,B Jayashree (2003). Synthesis of carboxamides of 2′-amino-4′-(6bromo-3-coumarinyl) thiazole as analgesic and antiinflammatory agents.
M Alam,J Choi,Lee (2012). Synthesis of novel Schiff base analogues of 4-amino-1, 5dimethyl-2-phenylpyrazol-3-one and their evaluation for antioxidant and anti-inflammatory activity.
S Sondhi,N Singh,A Kumar,O Lozach,L Meijer (2006). Synthesis, anti-inflammatory, analgesic and kinase (CDK-1, CDK-5 and GSK-3) inhibition activity evaluation of benzimidazole/benzoxazole derivatives and some Schiff's bases.
Mario Filion,Nigel Phillips (1997). Anti‐inflammatory activity of cationic lipids.
Malgorzata Tyszka-Czochara,Agata Grzywacz,; Wili,Ski,Wlodzimierz Opoka (2014). The Role of Zinc in the Pathogenesis and Treatment of Central Nervous System (CNS) diseases. Implications of zinc Homeostasis for proper CNS Function.
C Chandramouli,M Shivanand,T Nayanbhai,B Bheemachari,R Udupi (2012). Synthesis and biological screening of certain new triazole schiff bases and their derivatives bearing substituted benzothiazole moiety.
T Kato,N Kato (2000). Mitochondrial dysfunction in bipolar disorder.
C Stork,P Renshaw (2005). Mitochondrial dysfunction in bipolar disorder: evidence from magnetic resonance spectroscopy research.
Jana Hroudova,Zdenek Fisar (2012). In vitro inhibition of mitochondrial respiratory rate by antidepressants.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

K.Hariprasath, I. Sudheer babu, P.Venkatesh, uupendrarao. 2015. "Antidepressant and Anti-Inflammatory Activities of Cationic Amphiphilic Complexes of Sulphadiazine". Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 14 (GJMR Volume 14 Issue B7).

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GJMR Volume 14 Issue B7

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

anti-inflammatory and antidepressant activity cationic amphiphilic bases metal complexes Schiff base

Classification

GJMR-B Classification NLMC Code: QV 37.5

Submission ReceivedDecember 11, 2013
Peer Review Double Blind
Handling Editor
Accepted January 4, 2014
Published January 15, 2014

Version of record

v1.2

Issue date

January 19, 2015

Language

English

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Article Matrices

Total Score: 144

Country: India

Subject: Global Journal of Medical Research

Authors: K.Hariprasath, I. Sudheer babu, P.Venkatesh, U.Upendra Rao. (PhD/Dr. count: 0)

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