Antiepileptic Drugs and the Relationship with the Intestinal Microbiota

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Matheus Amorim Grigorio
Matheus Amorim Grigorio Reviewer
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Henrique Hollanda Larangeira
Henrique Hollanda Larangeira
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Luciane Alves de Oliveira
Luciane Alves de Oliveira
4
Renata Gomes Ramalho dos Santos
Renata Gomes Ramalho dos Santos
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Cínthia Pereira Jacomini
Cínthia Pereira Jacomini
6
Tamires Santos Pinheiro
Tamires Santos Pinheiro
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Lucca Cardoso Damasceno
Lucca Cardoso Damasceno
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Nilcele Freire de oliveira
Nilcele Freire de oliveira

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GJMR Volume 23 Issue B3

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This review of the literature examines the use of antiepileptic medications and how they relate to gut microbiota. Relationships exist between the makeup of the intestinal microbiota and the development and execution of the most fundamental physiological processes. Additionally, it affects the functioning of the central nervous system (CNS) by interacting with the microbiota-intestine-brain axis. The use of pharmaceutical medication is one of the factors that can alter the composition of the gut microbiota. When treating epilepsy, various drug types are used, each with a different mechanism of action. Among the medications in question are topiramate, primidone, phenytoin, carbamazepine, and phenobarbital. The similarity in structure and function between enteric and nerve cells establishes the connection between the brain and the gut.

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

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Not applicable for this article.

Matheus Amorim Grigorio. 2026. \u201cAntiepileptic Drugs and the Relationship with the Intestinal Microbiota\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 23 (GJMR Volume 23 Issue B3): .

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Enhanced understanding of antiepileptic drugs and gut microbiota relationships.
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Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-B Classification: NLMC Code: WL 102
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v1.2

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January 2, 2024

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English

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This review of the literature examines the use of antiepileptic medications and how they relate to gut microbiota. Relationships exist between the makeup of the intestinal microbiota and the development and execution of the most fundamental physiological processes. Additionally, it affects the functioning of the central nervous system (CNS) by interacting with the microbiota-intestine-brain axis. The use of pharmaceutical medication is one of the factors that can alter the composition of the gut microbiota. When treating epilepsy, various drug types are used, each with a different mechanism of action. Among the medications in question are topiramate, primidone, phenytoin, carbamazepine, and phenobarbital. The similarity in structure and function between enteric and nerve cells establishes the connection between the brain and the gut.

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Antiepileptic Drugs and the Relationship with the Intestinal Microbiota

Henrique Hollanda Larangeira
Henrique Hollanda Larangeira
Luciane Alves de Oliveira
Luciane Alves de Oliveira
Renata Gomes Ramalho dos Santos
Renata Gomes Ramalho dos Santos
Cínthia Pereira Jacomini
Cínthia Pereira Jacomini
Tamires Santos Pinheiro
Tamires Santos Pinheiro
Lucca Cardoso Damasceno
Lucca Cardoso Damasceno
Nilcele Freire de oliveira
Nilcele Freire de oliveira

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