Antioxidant Activity of Phenyl Alanine Mandelates by Chemical and Electrochemical Methods

1
Usha S
Usha S
2
Charles Kanakam Christopher
Charles Kanakam Christopher
1 Sri Sairam Engineering College

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The objective of our study was to evaluate, in a population of Togolese People Living With HIV(PLWHIV), the agreement between three scores derived from the general population namely the Framingham score, the Systematic Coronary Risk Evaluation (SCORE), the evaluation of the cardiovascular risk (CVR) according to the World Health Organization.
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Food decomposition in human body due to the redox reactions results in the formation of reactive oxygen species (ROS). ROS obtained during metabolic activitities in our body are responsible for cancerous diseases. ROS are scavenged by hydroxyl radicals present in the small organic molecules. Novel small organic molecules like mandelic acid -amino acid complexes, possess the weak hydrogen bonds and vanderwaals forces of attractions in the complex formation results in the antioxidant property. The title compounds, Rphenyl alanine-Smandelate (RPASMA), Bis-L-phenyl alanine mandelate (BLPAMA) and L-phenyl alanine bis mandelate (BMALPA) are synthesised, carried out characterisation studies like FTIR, NMR, TG-DTA, mass, UV and melting point and grown single crystal by slow evaporation technique confirmed the structure by single crystal XRD. The electrochemical behaviour of the phenyl alanine mandelates show the existence of redox activity using cyclic voltammetry and is confirmed by comparing with the chemical behaviour using DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging method.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

Usha S. 2016. \u201cAntioxidant Activity of Phenyl Alanine Mandelates by Chemical and Electrochemical Methods\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 16 (GJMR Volume 16 Issue B1): .

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-B Classification: NLMC Code: QV 325
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v1.2

Issue date

May 31, 2016

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English

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Food decomposition in human body due to the redox reactions results in the formation of reactive oxygen species (ROS). ROS obtained during metabolic activitities in our body are responsible for cancerous diseases. ROS are scavenged by hydroxyl radicals present in the small organic molecules. Novel small organic molecules like mandelic acid -amino acid complexes, possess the weak hydrogen bonds and vanderwaals forces of attractions in the complex formation results in the antioxidant property. The title compounds, Rphenyl alanine-Smandelate (RPASMA), Bis-L-phenyl alanine mandelate (BLPAMA) and L-phenyl alanine bis mandelate (BMALPA) are synthesised, carried out characterisation studies like FTIR, NMR, TG-DTA, mass, UV and melting point and grown single crystal by slow evaporation technique confirmed the structure by single crystal XRD. The electrochemical behaviour of the phenyl alanine mandelates show the existence of redox activity using cyclic voltammetry and is confirmed by comparing with the chemical behaviour using DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging method.

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Antioxidant Activity of Phenyl Alanine Mandelates by Chemical and Electrochemical Methods

Usha S
Usha S Sri Sairam Engineering College
Charles Kanakam Christopher
Charles Kanakam Christopher

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