Antivirt ®{Al 4 (SiO 4 ) 3 + 3Mg 2 SiO 4 → 2Al 2 Mg 3 (SiO 4 ) 3 } Enhances Efficacy of Co-trimoxazole in Terminating Experimental Trypanosome Infections in Mice

Antivirt ®{Al 4 (SiO 4 ) 3 + 3Mg 2 SiO 4 → 2Al 2 Mg 3 (SiO 4 ) 3 } Enhances Efficacy of Co-trimoxazole in Terminating Experimental Trypanosome Infections in Mice

M. C. O. Ezeibe

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M. I. Ezeja

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C. A

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I.O. Onyeachonam

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M. E. Sanda

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I. J. Ogbonna

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E. Kalu

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N.U. Njoku

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M.I. Udobi

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Michael Okpara University of Agriculture

Antivirt ®{Al 4 (SiO 4 ) 3 + 3Mg 2 SiO 4 → 2Al 2 Mg 3 (SiO 4 ) 3 } Enhances Efficacy of Co-trimoxazole in Terminating Experimental Trypanosome Infections in Mice

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Abstract

Both bacteria and protozoa require Folic acid for replication and Cotrimoxazole inhibits synthesis of the vitamin. For its mechanism of inhibiting Folic acid, the medicine has been in use as antibacterial drug for many decades but it is not being used to treat trypanosomosis (protozoan disease). To enhance anti-Folic acid activity of the medicine in order to improve its anti-trypanosome efficacy and make it function as new medicine for sleeping sickness (tropical disease of man and animals) it was stabilized with Antivirt® (Medicinal synthetic Aluminum-magnesium silicate). At 100 % of its antibacterial dose, Cotrimoxazole significantly reduced (P≤ 0.05) trypanosome parasitemia in mice, from 12.76±1.20 to 5. 87± 0.43. When it was stabilized with the Antivirt®, 75 % of the antibacterial dose had slight reduction (P≥ 0.05) in the trypanosome parasitemia (11.30±1.01) while the 100 % -dose achieved zero (0.00±00) trypanosome parasitemia and improved total WBC counts (immunity) from 1.50±0.16 to 2.86±0.38.

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No external funding was declared for this work.

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The authors declare no conflict of interest.

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How to Cite This Article

M. C. O. Ezeibe. 2020. \u201cAntivirt ®{Al 4 (SiO 4 ) 3 + 3Mg 2 SiO 4 → 2Al 2 Mg 3 (SiO 4 ) 3 } Enhances Efficacy of Co-trimoxazole in Terminating Experimental Trypanosome Infections in Mice\u201d. Global Journal of Medical Research - G: Veterinary Science & Medicine GJMR-G Volume 20 (GJMR Volume 20 Issue G3): .

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GJMR Volume 20 Issue G3
Pg. 19- 23

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Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-G Classification: NLMC Code: QW 70

Submission ReceivedDecember 6, 2019
Peer Review Double Blind
Handling Editor
Accepted January 1, 2020
Published January 15, 2020

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September 29, 2020

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