Assay for Quantitative Analysis of Losartan Potassium by using UV Spectroscopy

1
Zehra Ashraf
Zehra Ashraf
2
Nimra Waheed
Nimra Waheed
3
Erum Naz
Erum Naz
4
Fatima Ahmed
Fatima Ahmed
5
Taiba  Asim
Taiba Asim
6
Fatima Muzammil
Fatima Muzammil
7
Syeda Saghira and Maria Ayub
Syeda Saghira and Maria Ayub
1 Faculty of Pharmacy Jinnah University for Women, Karachi.

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Drug is a substance that brings about a change in the biological functions through its chemical actions. Drug losartan are the first marketed beta blockers of the angiotensin II-type (AT1) receptor. It is the prototypic ARB. Their pharmacologic effect are very similar to the ACE inhibitors, because they also produce the arteriolar and venous dilation and block aldosteron secretion, thus lowers the blood pressure, decreases the salt and water retention. Its chemical name is losartan potassium. It is indicated in mild to severe hypertension and contraindicated in pregnancy because it increases teratogenic risk and may leads to mal formation or death of fetus. It is light yellow solid and stable under recommended storage conditions, freely soluble in water and soluble in alcohol. Losartan inhibit the binding of angiotensin II to type 1 in tissue (kidney and adrenal gland) losartan and its active metabolite is more potent then losartan inhabitation causes vasodilation and decreases sodium and water retention. The aim of study is to determine the %age assay of losartan potassium of different brands.

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No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

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Not applicable for this article.

Zehra Ashraf. 2015. \u201cAssay for Quantitative Analysis of Losartan Potassium by using UV Spectroscopy\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 15 (GJMR Volume 15 Issue B4): .

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Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-B Classification: NLMC Code: QV 704
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v1.2

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October 5, 2015

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English

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Drug is a substance that brings about a change in the biological functions through its chemical actions. Drug losartan are the first marketed beta blockers of the angiotensin II-type (AT1) receptor. It is the prototypic ARB. Their pharmacologic effect are very similar to the ACE inhibitors, because they also produce the arteriolar and venous dilation and block aldosteron secretion, thus lowers the blood pressure, decreases the salt and water retention. Its chemical name is losartan potassium. It is indicated in mild to severe hypertension and contraindicated in pregnancy because it increases teratogenic risk and may leads to mal formation or death of fetus. It is light yellow solid and stable under recommended storage conditions, freely soluble in water and soluble in alcohol. Losartan inhibit the binding of angiotensin II to type 1 in tissue (kidney and adrenal gland) losartan and its active metabolite is more potent then losartan inhabitation causes vasodilation and decreases sodium and water retention. The aim of study is to determine the %age assay of losartan potassium of different brands.

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Assay for Quantitative Analysis of Losartan Potassium by using UV Spectroscopy

Zehra Ashraf
Zehra Ashraf Faculty of Pharmacy Jinnah University for Women, Karachi.
Nimra Waheed
Nimra Waheed
Erum Naz
Erum Naz
Fatima Ahmed
Fatima Ahmed
Taiba  Asim
Taiba Asim
Fatima Muzammil
Fatima Muzammil
Syeda Saghira and Maria Ayub
Syeda Saghira and Maria Ayub

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