Assay for Quantitative Analysis of Losartan Potassium by using UV Spectroscopy

Assay for Quantitative Analysis of Losartan Potassium by using UV Spectroscopy

Zehra Ashraf

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Nimra Waheed

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Erum Naz

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Fatima Ahmed

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Taiba Asim

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Fatima Muzammil

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Syeda Saghira and Maria Ayub

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Jinnah University for Women

Assay for Quantitative Analysis of Losartan Potassium by using UV Spectroscopy

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Abstract

Drug is a substance that brings about a change in the biological functions through its chemical actions. Drug losartan are the first marketed beta blockers of the angiotensin II-type (AT1) receptor. It is the prototypic ARB. Their pharmacologic effect are very similar to the ACE inhibitors, because they also produce the arteriolar and venous dilation and block aldosteron secretion, thus lowers the blood pressure, decreases the salt and water retention. Its chemical name is losartan potassium. It is indicated in mild to severe hypertension and contraindicated in pregnancy because it increases teratogenic risk and may leads to mal formation or death of fetus. It is light yellow solid and stable under recommended storage conditions, freely soluble in water and soluble in alcohol. Losartan inhibit the binding of angiotensin II to type 1 in tissue (kidney and adrenal gland) losartan and its active metabolite is more potent then losartan inhabitation causes vasodilation and decreases sodium and water retention. The aim of study is to determine the %age assay of losartan potassium of different brands.

References

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Zehra Ashraf. 2015. \u201cAssay for Quantitative Analysis of Losartan Potassium by using UV Spectroscopy\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 15 (GJMR Volume 15 Issue B4).

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GJMR Volume 15 Issue B4

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

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Classification

GJMR-B Classification NLMC Code: QV 704

Submission ReceivedApril 15, 2015
Peer Review Double Blind
Handling Editor
Accepted May 3, 2015
Published May 15, 2015

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v1.2

Issue date

October 5, 2015

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Article Matrices

Total Score: 107

Country: Pakistan

Subject: Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine

Authors: Zehra Ashraf, Nimra Waheed, Erum Naz, Fatima Ahmed, Taiba Asim, Fatima Muzammil, Syeda Saghira and Maria Ayub (PhD/Dr. count: 0)

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Total Views: 4354

Total Downloads: 2169

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