Association of Rs763780 Polymorphism of Gene IL17F with the Risk of Developing Rheumatoid Arthritis in Uzbekistan

M. Sh. Karimov; A. A. Eshmurzaeva; Kh. M. Marufkhanov; M. V. Sibirkina

Association of Rs763780 Polymorphism of Gene IL17F with the Risk of Developing Rheumatoid Arthritis in Uzbekistan

M. Sh. Karimov * §

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A. A. Eshmurzaeva

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Kh. M. Marufkhanov

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M. V. Sibirkina

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§ Tashkent Medical Academy

Association of Rs763780 Polymorphism of Gene IL17F with the Risk of Developing Rheumatoid Arthritis in Uzbekistan

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Abstract

As a result of the study conducted, it was witnessed that the G allele and the heterozygous A / G genotype of the IL17F gene (rs763780) among patients with RA are significantly higher than in the control group. In particular, the most significant discrepancies were registered in patients with articular-visceral form of the disease whom the G allele exceeded the proportion of carriage in the control statistically significantly 2.58 times (χ2 = 4.512; P = 0.037; OR = 2.58; 95% CI: 1.076 -6.188). On the part of the heterozygous genotype A / G there was a clear tendency to increase its frequency by more than twice (χ2 = 2.011; P = 0.165; OR = 2.068; 95% CI: 0758-5.645) which in turn indicates the possible participation of the studied polymorphism in the pathogenesis of RA.

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No external funding was declared for this work.

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The authors declare no conflict of interest.

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How to Cite This Article

M. Sh. Karimov, A. A. Eshmurzaeva, Kh. M. Marufkhanov, M. V. Sibirkina. 2021. "Association of Rs763780 Polymorphism of Gene IL17F with the Risk of Developing Rheumatoid Arthritis in Uzbekistan". Global Journal of Medical Research - H: Orthopedic & Musculoskeletal System GJMR-H Volume 21 (GJMR Volume 21 Issue H2).

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GJMR Volume 21 Issue H2

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Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-H Classification NLMC Code: WE 346

Submission ReceivedDecember 12, 2020
Peer Review Double Blind
Handling Editor
Accepted January 3, 2021
Published January 15, 2021

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v1.2

Issue date

September 15, 2021

Language

English

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