Neural Networks and Rules-based Systems used to Find Rational and Scientific Correlations between being Here and Now with Afterlife Conditions
February 17, 2026
Neural Networks and Rules-based Systems used to Find Rational and
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Juvenile idiopathic arthritis (JIA) is a heterogeneous pathology with uncertain causative factors and prognosis, stemming from an immune system dysfunction with the development of autoimmune reactions. The most distinctive and potentially most severe of these is systemic JIA (sJIA), a disease characterized by sharp rises in temperature and rash. A thorough understanding of the complex of immune regulatory mechanisms along with genetic analysis reveals complex relationships between autoimmune reactions and auto inflammation. Sequencing of 15 auto inflammatory genes was performed in 62 patients with JIA: 26 -oligoarthritis, 20 -polyarthritis, 16 -systemic. Studies have shown that 16 (25.8%) patients with the clinical JIA phenotype had changes in nucleotide sequence in the genes encoding auto inflammatory immune response proteins. NOD2 changes were in 12 (19.3%) of them and 1 change in each of the 4 patients NLRP12 (heterozygote, c.1343G> C (p.Gly448Ala)), MEFV (pathogenic heterozygous, c.2082G> A (p.Met694Ile)), ADA2 (heterozygote, c.145C> T). Arg49Trp)), PSTPIP1 (heterozygote, c.806T> A (p.Ile269A)) in the group of studied children with JIA. The study will allow identifying individual genetic loci of JIA risk, expand understanding of the pathogenesis and spectrum of phenotypic manifestations of the disease, improve diagnosis and prediction of its course, as well as reveal new opportunities for monitoring patients with JIA and their personalized therapy.
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Mukvich Olena. 2026. \u201cAutoinflammation Candidate Genes in Juvenile Idiopathic Arthritis\u201d. Global Journal of Science Frontier Research - G: Bio-Tech & Genetics GJSFR-G Volume 22 (GJSFR Volume 22 Issue G2): .
Crossref Journal DOI 10.17406/GJSFR
Print ISSN 0975-5896
e-ISSN 2249-4626
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