Bone Marrow Lymphocyte Populations of Innate Immunity in Breast Cancer Patients

Bone Marrow Lymphocyte Populations of Innate Immunity in Breast Cancer Patients

N.N. Tupitsyn

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V.A. Mkrtchyan

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A.D. Palladina

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I.K.Vorotnikov

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Bone Marrow Lymphocyte Populations of Innate Immunity in Breast Cancer Patients

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Abstract

The innate immunity system plays an important role in antitumor protection, and more and more attention has been paid to its study recent years. However, the interrelation of the effect or subpopulations of the cells of the innate immunity in bone marrow with clinical parameters is poorly studied. The paper presents data on the composition of innate immune cells in the bone marrow of 64 patients with operable breast cancer, as well as 10 women with benign processes in the mammary gland. As result a significant correlation between the molecular subtype of cancer and the level of B1-lymphocytes was identified. Breast cancer patients levels of NK cells (CD56 + CD3-and CD16 + CD3-) in the bone marrow were significantly higher in patients with low proliferative activity (Ki-67 less than 20%), compared to patients having a high tumor proliferation index. Populations of NK cells were interrelated with erythropoiesis in patients with breast cancer and were significantly higher in cases of reduced basophilic and polychromatophilicnormoblasts.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

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How to Cite This Article

N.N. Tupitsyn. 2020. \u201cBone Marrow Lymphocyte Populations of Innate Immunity in Breast Cancer Patients\u201d. Global Journal of Medical Research - F: Diseases GJMR-F Volume 20 (GJMR Volume 20 Issue F2): .

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GJMR Volume 20 Issue F2
Pg. 21- 27

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Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-F Classification: NLMC Code: WC 524, WH 380

Submission ReceivedDecember 14, 2019
Peer Review Double Blind
Handling Editor
Accepted January 2, 2020
Published January 15, 2020

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v1.2

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February 27, 2020

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