Brunner Gland Adenoma with a KRAS G12D Point Mutation
Brunner gland lesions (BGL) encompass benign proliferations of the homonymous glands and have been designated as hyperplasia, adenoma (BGA), hamartoma or nodule. In general terms, lesions larger than 0.5 cm are considered true neoplasia with an unknown malignant potential and unclear pathogenesis. Genetic alterations have seldom been reported in BGL, and include SMAD4/DPC4 and LRIG1, but not KRAS to the best of our knowledge. We present a 64-year-old man evaluated for iron deficiency anemia harboring a 1.5 cm BGA found by duodenoscopy. Immunohistochemistry failed to reveal microsatellite instability, and next generation sequencing revealed a KRAS G12D point mutation.
