Celiac Disease: An Assessment of Subjective Variation and Diagnostic Reproducibility of the Various Classification Systems

1
Manas Madan
Manas Madan
2
Sanjay Piplani
Sanjay Piplani
3
Manisha Sharma
Manisha Sharma
4
Tejinder Singh Bhasin
Tejinder Singh Bhasin
5
Mridu Manjari
Mridu Manjari
6
Harjot Kaur
Harjot Kaur
7
Jasmeet kaur
Jasmeet kaur
8
Saumil Garg
Saumil Garg
1 Guru Ramdass Institute of Medical Sciences & Research, Amritsar, Punjab, India
2 SGRDIMSR, Amritsar, Baba Farid University
3 SGRDIMSAR, Amritsar
6 SRi GURU RAM DAS INSTITUTE OF MEDICAL SCIENCES AND RESEARCH

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Introduction: Celiac disease (CD) is a chronic immune mediated disorder occurring in genetically predisposed individuals with intolerance to gluten, particularly its protein gliadin. The histological examination still remains the gold standard for its diagnosis. Marsh-Oberhuber classification is very widely used by pathologists for the diagnosis of CD and is valid under optimal clinical conditions. However, due to the presence of greater diagnostic categories, it lends itself to greater subjective variability and lower interobserver and intraobserver agreement and hence lower reproducibility of the diagnosis. Recently, Corazza and Villanacci introduced a classification that reduces the number of categories and the interobserver variation. This study was undertaken to observe the reproducibility of the Marsh-Oberhuber classification in comparison to the newer Corazza and Villanacci classification and determine the intra and interobserver variation in both the classifications.

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

Manas Madan. 2015. \u201cCeliac Disease: An Assessment of Subjective Variation and Diagnostic Reproducibility of the Various Classification Systems\u201d. Global Journal of Medical Research - C: Microbiology & Pathology GJMR-C Volume 15 (GJMR Volume 15 Issue C1): .

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Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords
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GJMR-C Classification: NLMC Code: WD 175
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February 28, 2015

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English

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Introduction: Celiac disease (CD) is a chronic immune mediated disorder occurring in genetically predisposed individuals with intolerance to gluten, particularly its protein gliadin. The histological examination still remains the gold standard for its diagnosis. Marsh-Oberhuber classification is very widely used by pathologists for the diagnosis of CD and is valid under optimal clinical conditions. However, due to the presence of greater diagnostic categories, it lends itself to greater subjective variability and lower interobserver and intraobserver agreement and hence lower reproducibility of the diagnosis. Recently, Corazza and Villanacci introduced a classification that reduces the number of categories and the interobserver variation. This study was undertaken to observe the reproducibility of the Marsh-Oberhuber classification in comparison to the newer Corazza and Villanacci classification and determine the intra and interobserver variation in both the classifications.

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Celiac Disease: An Assessment of Subjective Variation and Diagnostic Reproducibility of the Various Classification Systems

Manas Madan
Manas Madan
Sanjay Piplani
Sanjay Piplani SGRDIMSR, Amritsar, Baba Farid University
Manisha Sharma
Manisha Sharma SGRDIMSAR, Amritsar
Tejinder Singh Bhasin
Tejinder Singh Bhasin
Mridu Manjari
Mridu Manjari
Harjot Kaur
Harjot Kaur SRi GURU RAM DAS INSTITUTE OF MEDICAL SCIENCES AND RESEARCH
Jasmeet kaur
Jasmeet kaur
Saumil Garg
Saumil Garg

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