Celiac Disease: An Assessment of Subjective Variation and Diagnostic Reproducibility of the Various Classification Systems

Manas Madan; Sanjay Piplani; Manisha Sharma; Tejinder Singh Bhasin

Celiac Disease: An Assessment of Subjective Variation and Diagnostic Reproducibility of the Various Classification Systems

Manas Madan * §

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Sanjay Piplani ‡

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Manisha Sharma ‡

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Tejinder Singh Bhasin §

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Mridu Manjari ¶

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§ Guru Ramdass Institute of Medical Sciences & Researc...

‡ Baba Farid University of Health Sciences

¶ SGRDIMSAR, Amritsar

Celiac Disease: An Assessment of Subjective Variation and Diagnostic Reproducibility of the Various Classification Systems

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Abstract

Introduction: Celiac disease (CD) is a chronic immune mediated disorder occurring in genetically predisposed individuals with intolerance to gluten, particularly its protein gliadin. The histological examination still remains the gold standard for its diagnosis. Marsh-Oberhuber classification is very widely used by pathologists for the diagnosis of CD and is valid under optimal clinical conditions. However, due to the presence of greater diagnostic categories, it lends itself to greater subjective variability and lower interobserver and intraobserver agreement and hence lower reproducibility of the diagnosis. Recently, Corazza and Villanacci introduced a classification that reduces the number of categories and the interobserver variation. This study was undertaken to observe the reproducibility of the Marsh-Oberhuber classification in comparison to the newer Corazza and Villanacci classification and determine the intra and interobserver variation in both the classifications.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Manas Madan, Sanjay Piplani, Manisha Sharma, Tejinder Singh Bhasin, Mridu Manjari. 2015. "Celiac Disease: An Assessment of Subjective Variation and Diagnostic Reproducibility of the Various Classification Systems". Global Journal of Medical Research - C: Microbiology & Pathology GJMR-C Volume 15 (GJMR Volume 15 Issue 1 (C1)).

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GJMR Volume 15 Issue 1 (C1)

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

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Classification

GJMR-C Classification NLMC Code: WD 175

Submission ReceivedDecember 14, 2014
Peer Review Double Blind
Handling Editor
Accepted January 4, 2015
Published January 15, 2015

Version of record

v1.2

Issue date

January 15, 2015

Language

English

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Article Matrices

Total Score: 108

Country: India

Subject: Global Journal of Medical Research - C: Microbiology & Pathology

Authors: Manas Madan, Sanjay Piplani, Manisha Sharma, Tejinder Singh Bhasin, Mridu Manjari, Harjot Kaur, Jasmeet kaur, Saumil Garg (PhD/Dr. count: 0)

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