Cell Cycle Aberration in Ameloblastoma: as Evidenced by an Immunohistochemical Expression  of P53 and Survivin

Cell Cycle Aberration in Ameloblastoma: as Evidenced by an Immunohistochemical Expression of P53 and Survivin

Dr. Zulfin Shaikh

Contact

Dr. Niranjan K C

Contact

Rajiv Gandhi University of Health Sciences

Cell Cycle Aberration in Ameloblastoma: as Evidenced by an Immunohistochemical Expression of P53 and Survivin

Article Fingerprint

ReserarchID

3HCLP

Cell Cycle Aberration in Ameloblastoma: as Evidenced by an Immunohistochemical Expression of P53 and Survivin Banner

AI TAKEAWAY

Connecting with the Eternal Ground

Abstract

Evasion from apoptosis by aberrations of apoptotic regulatory factors has been found to cause accumulation of neoplastic cells in various tumours. Survivin, an inhibitor of apoptosis protein localizes to the nucleus as well as in the cytoplasm depending on its function such as cell division and inhibiting apoptosis. The regulation of Survivin seems to be linked to p53, a tumour suppressor gene. Though there are studies showing the role of p53 and Survivin in oral carcinogenesis, but the field of odontogenic tumours yet needs to be explored. The aim of this study was to correlate the expression of p53 and Survivin in normal tissues (tooth germ) and Ameloblastoma as well as to assess differential localization of Survivin. Qualitative and quantitative assess-ment of immunexpression of p53 and Survivin (nuclear and cytoplasmic) was evaluated in a total of 35 cases which included 10 tooth germs and 25 Ameloblastoma. The expression levels of p53 and nuclear Survivin were significantly higher in Ameloblastoma quantitatively but there was no significant correlation between p53 and cytoplasmic expression of Survivin.

References

38 Cites in Article

Reference Format

Hiroyuki Kumamoto (2010). Molecular alterations in the development and progression of odontogenic tumors.
H Kumamoto (2006). Molecular pathology of odontogenic tumors.
H Philipsen (1998). Cell Cycle Aberration in Ameloblastoma: As Evidenced by an Immunohistochemical Expression of p53 and Survivin" survivin.
Carl Miller,T Mohandas,D Wolf,M Prokocimer,V Rotter,H Phillip Koeffler (1986). Human p53 gene localized to short arm of chromosome 17.
L Loro,O Vintermyr,A Johannessen (2005). Apoptosis in normal and diseased oral tissues.
Y Shi (2000). Survivin structure: crystal unclear.
Dario Altieri (2006). The case for survivin as a regulator of microtubule dynamics and cell-death decisions.
Shirley Knauer,Wolf Mann,Roland Stauber (2007). Survivin’s Dual Role: An Export’s View.
Roland Stauber,Wolf Mann,Shirley Knauer (2007). Nuclear and Cytoplasmic Survivin: Molecular Mechanism, Prognostic, and Therapeutic Potential.
Shirley Knauer,Oliver Krämer,Thomas Knösel,Knut Engels,Franz Rödel,Adorján Kovács,Wolfgang Dietmaier,Ludger Klein‐hitpass,Negusse Habtemichael,Andrea Schweitzer,Jürgen Brieger,Claus Rödel,Wolf Mann,Iver Petersen,Thorsten Heinzel,Roland Stauber (2007). Nuclear export is essential for the tumor‐promoting activity of survivin.
G Qi,H Tuncel,E Aoki (2009). Intracellular localization of survivin determines biological behavior in colorectal cancer.
Fengzhi Li,Jie Yang,Nithya Ramnath,Milind Javle,Dongfeng Tan (2005). Nuclear or cytoplasmic expression of survivin: What is the significance?.
Asra Mirza,Marnie Mcguirk,Tish Hockenberry,Qun Wu,Hena Ashar,Stuart Black,Shu Wen,Luquan Wang,Paul Kirschmeier,W Bishop,Loretta Nielsen,Cecil Pickett,Suxing Liu (2002). Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway.
G Lo Muzio,Pannone,Staibano (2003). Survivin expression in oral squamous cell carcinoma.
Ping Chen,Jian Li,Li‐ping Ge,Chun‐hua Dai,Xiao‐qin Li (2010). Prognostic value of survivin, X‐linked inhibitor of apoptosis protein and second mitochondria‐derived activator of caspases expression in advanced non‐small‐cell lung cancer patients.
J Choi,H Chang (2012). The expression of MAGE and SSX, and correlation of COX2, VEGF, and survivin in colorectal cancer.
Aziza Nassar,Debbie Sexton,George Cotsonis,Cynthia Cohen (2008). Survivin Expression in Breast Carcinoma: Correlation With Apoptosis and Prognosis.
J Kim,J Chung,S Lee (2006). Nuclear interaction of Smac/DIABLO with Survivin at G2/M arrest prompts docetaxel-induced apoptosis in DU145 prostate cancer cells.
Takeshi Ito,Katsuya Shiraki,Kazushi Sugimoto,Takenari Yamanaka,Katsuhiko Fujikawa,Masaaki Ito,Koujiro Takase,Masami Moriyama,Hirokazu Kawano,Midori Hayashida,Takeshi Nakano,Atsushi Suzuki (2000). Survivin promotes cell proliferation in human hepatocellular carcinoma.
Carlos Barboza,Leão Pinto,Roseana Freitas,Antônio Costa,Lélia Souza (2005). Proliferating cell nuclear antigen (PCNA) and p53 protein expression in ameloblastoma and adenomatoid adontogenic tumor.
J Carvalhais,De Aguiar,V De Araujo (1995). P53 and MDM2 expression in odontogenic cysts and tumours.
Susanne Lens,Gerben Vader,René Medema (2006). The case for Survivin as mitotic regulator.
Shirley Knauer,Carolin Bier,Negusse Habtemichael,Roland Stauber (2006). The Survivin–Crm1 interaction is essential for chromosomal passenger complex localization and function.
F Li (2005). Role of surviving and its splice variants in tumorigenesis.
Anna Parenti,Genesio Leo,Andrea Porzionato,Giovanni Zaninotto,Antonio Rosato,Vito Ninfo (2006). Expression of survivin, p53, and caspase 3 in Barrett's esophagus carcinogenesis.
Marian Adamkov,Erika Halasova,Julius Rajcani,Marian Bencat,Desanka Vybohova,Silvia Rybarova,Stefan Galbavy (2011). Relation between expression pattern of p53 and survivin in cutaneous basal cell carcinomas.
K Ranade,A Nerurkar,M Phulpagar (2009). Expression of Survivin and p53 proteins and their correlation with hormone receptor status in Indian breast cancer patients.
E Halasova,M Adamkov,E Kavcova (2009). Expression of anti-apoptotic protein survivin and tumor suppressor p53 protein in patients with pulmonary carcinoma.
N El-Sissy (1999). Immunohistochemical detection of p53 protein in ameloblastoma types.
K Al-Salihi,L Li,A ; Azlina,R Stauber,W Mann,S Knauer (2006). Cell Cycle Aberration in Ameloblastoma: As Evidenced by an Immunohistochemical Expression of p53 and Survivin.
Michiko Shintani,Akiko Sangawa,Naoki Yamao,Shingo Kamoshida (2013). Smac/DIABLO expression in human gastrointestinal carcinoma: Association with clinicopathological parameters and survivin expression.
Márcia De Oliveira,Isabel Da Silva Lauxen,Anna Chaves,Pantelis Rados,Manoel Sant’ana Filho (2010). Odontogenic Epithelium: Immunolabeling of Ki-67, EGFR and Survivin in Pericoronal Follicles, Dentigerous Cysts and Keratocystic Odontogenic Tumors.
Hiroyuki Kumamoto,Kiyoshi Ooya (2004). Expression of survivin and X chromosome-linked inhibitor of apoptosis protein in ameloblastomas.
M Andric,B Dozic,B Popovic (2010). Survivin expression in odontogenic keratocysts and correlation with cytomegalovirus infection.
Monica Hollstein,David Sidransky,Bert Vogelstein,Curtis Harris (1991). p53 Mutations in Human Cancers.
Al-Fayad Dws (2010). Immunohistochemical Expression of P53 in Different Types of Ameloblastoma.
L Bai,W Zhu (2006). p53: Structure, Function and Therapeutic Applications.
Dario Altieri (2003). Survivin, versatile modulation of cell division and apoptosis in cancer.

Download References

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Dr. Zulfin Shaikh. 2014. \u201cCell Cycle Aberration in Ameloblastoma: as Evidenced by an Immunohistochemical Expression of P53 and Survivin\u201d. Global Journal of Medical Research - J: Dentistry & Otolaryngology GJMR-J Volume 14 (GJMR Volume 14 Issue J6).

More Citation Formats

Select Citation Style:

Download Citation

GJMR Volume 14 Issue J6

Explore Journals Explore Volume Read This Issue

Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

aberrations ameloblastoma apoptosis immunohistochemical expression inhibitor of apoptosis pr p53 survivin tumorigenesis tumour suppressor gene

Submission ReceivedDecember 6, 2013
Peer Review Double Blind
Handling Editor
Accepted January 3, 2014
Published January 15, 2014

Version of record

v1.2

Issue date

December 25, 2014

Language

Experiance in AR

Explore published articles in an immersive Augmented Reality environment. Our platform converts research papers into interactive 3D books, allowing readers to view and interact with content using AR and VR compatible devices.

View in VR

Read in 3D

Your published article is automatically converted into a realistic 3D book. Flip through pages and read research papers in a more engaging and interactive format.

View in 3D

Article Matrices

Total Score: 112

Country: India

Subject: Global Journal of Medical Research - J: Dentistry & Otolaryngology

Authors: Dr. Zulfin Shaikh, Dr. Niranjan K C (PhD/Dr. count: 2)

View Count (all-time): 199

Total Views (Real + Logic): 4435

Total Downloads (simulated): 2124

Publish Date: 2014 12, Thu

Monthly Totals (Real + Logic):

Month 1: 64 views
Month 2: 50 views
Month 3: 42 views
Month 4: 69 views
Month 5: 20 views
Month 6: 42 views
Month 7: 44 views
Month 8: 15 views
Month 9: 48 views
Month 10: 37 views
Month 11: 41 views
Month 12: 31 views
Month 13: 22 views
Month 14: 24 views
Month 15: 38 views
Month 16: 28 views
Month 17: 16 views
Month 18: 33 views
Month 19: 35 views
Month 20: 31 views
Month 21: 31 views
Month 22: 15 views
Month 23: 35 views
Month 24: 37 views
Month 25: 43 views
Month 26: 26 views
Month 27: 23 views
Month 28: 33 views
Month 29: 38 views
Month 30: 30 views
Month 31: 25 views
Month 32: 41 views
Month 33: 28 views
Month 34: 24 views
Month 35: 37 views
Month 36: 43 views
Month 37: 18 views
Month 38: 25 views
Month 39: 32 views
Month 40: 29 views
Month 41: 33 views
Month 42: 19 views
Month 43: 26 views
Month 44: 17 views
Month 45: 35 views
Month 46: 22 views
Month 47: 26 views
Month 48: 35 views
Month 49: 36 views
Month 50: 19 views
Month 51: 12 views
Month 52: 48 views
Month 53: 29 views
Month 54: 19 views
Month 55: 21 views
Month 56: 24 views
Month 57: 24 views
Month 58: 38 views
Month 59: 44 views
Month 60: 41 views
Month 61: 22 views
Month 62: 20 views
Month 63: 41 views
Month 64: 28 views
Month 65: 19 views
Month 66: 30 views
Month 67: 39 views
Month 68: 27 views
Month 69: 22 views
Month 70: 35 views
Month 71: 27 views
Month 72: 24 views
Month 73: 34 views
Month 74: 20 views
Month 75: 42 views
Month 76: 40 views
Month 77: 35 views
Month 78: 28 views
Month 79: 37 views
Month 80: 36 views
Month 81: 20 views
Month 82: 31 views
Month 83: 16 views
Month 84: 23 views
Month 85: 17 views
Month 86: 46 views
Month 87: 20 views
Month 88: 15 views
Month 89: 27 views
Month 90: 26 views
Month 91: 29 views
Month 92: 40 views
Month 93: 49 views
Month 94: 43 views
Month 95: 28 views
Month 96: 27 views
Month 97: 35 views
Month 98: 23 views
Month 99: 29 views
Month 100: 28 views
Month 101: 34 views
Month 102: 37 views
Month 103: 24 views
Month 104: 28 views
Month 105: 32 views
Month 106: 28 views
Month 107: 35 views
Month 108: 20 views
Month 109: 35 views
Month 110: 40 views
Month 111: 23 views
Month 112: 25 views
Month 113: 36 views
Month 114: 26 views
Month 115: 42 views
Month 116: 32 views
Month 117: 40 views
Month 118: 29 views
Month 119: 49 views
Month 120: 34 views
Month 121: 37 views
Month 122: 36 views
Month 123: 41 views
Month 124: 11 views
Month 125: 23 views
Month 126: 32 views
Month 127: 41 views
Month 128: 25 views
Month 129: 18 views
Month 130: 44 views
Month 131: 26 views
Month 132: 23 views
Month 133: 32 views
Month 134: 46 views
Month 135: 74 views
Month 136: 38 views
Month 137: 31 views

Total Views: 4435

Total Downloads: 2124

2026 Trends

Our website is actively being updated, and changes may occur frequently. Please clear your browser cache if needed. For feedback or error reporting, please email [email protected]