Chronic Inflammation Induced Immunosuppression Tumor Microenvironment of Oral Cancer

Chronic Inflammation Induced Immunosuppression Tumor Microenvironment of Oral Cancer

Shrihari T.G

Contact

Ramesh DNSV

Contact

Chronic Inflammation Induced Immunosuppression Tumor Microenvironment of Oral Cancer

Article Fingerprint

ReserarchID

01K28

Chronic Inflammation Induced Immunosuppression Tumor Microenvironment of Oral Cancer Banner

AI TAKEAWAY

Connecting with the Eternal Ground

Abstract

Oral Cancer is a wound that do not heal is a complex disease consists of heterogeneous tissue in their tumor microenvironment. Oral cancer accounts eighth most Common Cancer worldwide. Chronic inflammatory mediators released from immune cells in tumor microenvironment of oral cancer such as macrophages, T lymphocytes, dendritic cells, Natural killer cells release cytokines, Chemokine’s and growth factors helps in generation of myeloid derived suppressor cells. Myeloid derived suppressor cells are derived from myeloid progenitor cells of bone marrow secretes inflammatory mediators iNOS, arginase-1, PGE2,IL-10 and IL-4 suppresses adaptive and innate immunity by interacting with macrophages, T-cells, Natural killer cells and dendritic cells favours pro-tumoral activity by activating transcriptional factors (NF-KB,STAT -3,HIF) further progress in to oral cancer. Myeloid derived suppressor cells reduces T cell activation and function by Arginase-1, iNOS, peroxynitrate over expression and cysteine depletion.

References

89 Cites in Article

Reference Format

A Pietras K, Ostman (2010). Hallmarks of cancer; Interactions with the tumorstroma.
T Condamine,I Ramachandran,J Youn,D Gabrilovich (2015). Regulation of tumor metastasis by myeloid-derived suppressor cells.
E Peranzoni,S Zilio,I Marigo,L Dolcetti,P Zanovello,S Mandruzzato,V Bronte (2010). Myeloid-derived suppressor cell heterogeneity and subset definition.
F Colotta,P Allavena,A Sica,C Garlanda,A Mantovani (2009). Cancer -related inflammation, the seventh hallmark of cancer; links to genetic instability.
Tania Fiaschi,Paola Chiarugi (2012). Oxidative Stress, Tumor Microenvironment, and Metabolic Reprogramming: A Diabolic Liaison.
H Bauer,T Jung,D Tsikas,D Stichtenoth,C Frölich,C Neumann (1997). Nitric oxide inhibits the secretion of T‐helper 1‐ and T‐helper 2‐associated cytokines in activated human T cells‘pa.
W Sosroseno,P Bird,G Seymour (2009). Effect of exogenous nitric oxide on murine splenic immune response induced by Aggregatibacter actinomycetemcomitans lipopolysaccharide.
R Bingisser,P Tilbrook,P Holt,Kees U R (1998). Macrophage-derived nitric oxide regulates T cell activation via reversible disruption of the Jak3/ STAT5 signaling pathway.
Laura Edgington-Mitchell,Belinda Parker (2014). Disparate functions of myeloid-derived suppressor cells in cancer metastasis.
P Lejeune,P Lagadec,N Onier,D Pinard,H Ohshima,Jeannin,Jf (1994). Nitric oxide involvement in tumorinduced immunosuppression.
A Mazzoni,V Bronte,A Visintin,J H Spitzer,E Apolloni,P Serafini,P Zanovello,D Segal (2002). Myeloid suppressor lines inhibit T cell responses by an NOdependent mechanism.
Marianne Medot-Pirenne,Michelle Heilman,Malinee Saxena,Patricia Mcdermott,Charles Mills (1999). Augmentation of an Antitumor CTL Response In Vivo by Inhibition of Suppressor Macrophage Nitric Oxide.
Kazuya Sato,Katsutoshi Ozaki,Iekuni Oh,Akiko Meguro,Keiko Hatanaka,Tadashi Nagai,Kazuo Muroi,Keiya Ozawa (2007). Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells.
O Harari,J Liao (2004). Inhibition of MHC II gene transcription by nitric oxide and antioxidants.
L Rivoltini,M Carrabba,V Huber,C Castelli,L Novellino,P Dalerba (2002). Immunity to cancer: attack and escape in T lymphocyte-tumor cell interaction.
C Bogdan (2001). Nitric oxide and the immune response.
S Morris,Jr (2002). Regulation of Enzymes of Urea and Arginine Synthesis.
W Zhao,Y Xu,J Xu,D Wu,B Zhao,Z Yin,X Wang (2015). Subsets of myeloid-derived suppressor cells in hepatocellular carcinoma express chemokines and chemokine receptors differentially.
V Bronte,P Serafini,De Santo,C Marigo,I Tosello,V Mazzoni,A (2003). IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing mice.
J Medina-Echeverz,F Aranda,P Berraondo (2014). Myeloid-derived cells are key targets of tumor immunotherapy.
Paulo Rodríguez,Augusto Ochoa (2008). Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives.
K Parker,D Beury,S Ostrand-Rosenberg (2015). Myeloid-Derived Suppressor Cells: Critical Cells Driving Immune Suppression in the Tumor Microenvironment.
S Nagaraj,K Gupta,V Pisarev,L Kinarsky,S Sherman,L Kang,D Herber,J Schneck,D Gabrilovich (2007). Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer.
Jingwei Jiang,Weijian Guo,Xiaohua Liang (2014). Phenotypes, accumulation, and functions of myeloid-derived suppressor cells and associated treatment strategies in cancer patients.
M Srivastava,P Sinha,V Clements,P Rodriguez,S Ostrand-Rosenberg (2010). Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine.
A Keskinov,M Shurin (2015). Myeloid regulatory cells in tumor spreading and metastasis.
S Ostrand -Rosenberg,P Sinha (2009). Myeloidderived suppressor cells: linking inflammation and cancer.
E Eruslanov,I Daurkin,J Ortiz,J Vieweg,S Kusmartsev (2010). Pivotal advance; Tumor -mediated induction of myeloid -derived suppressor cells and M2-polarized macrophages by altering intracellular PGE2 catabolism in myeloid cells.
D Legler,M Bruckner,E Vetz-Von Allmen,P Krause (2010). Prostaglandin E2 at new glance; Novel insights in functional diversity offer therapeutic chances.
Suzanne Ostrand-Rosenberg,Pratima Sinha,Daniel Beury,Virginia Clements (2012). Cross-talk between myeloid-derived suppressor cells (MDSC), macrophages, and dendritic cells enhances tumor-induced immune suppression.
Nahzli Dilek,Romain Vuillefroy De Silly,Gilles Blancho,Bernard Vanhove (2012). Myeloid-derived suppressor cells: mechanisms of action and recent advances in their role in transplant tolerance.
E Lo Manaco,E Tremante,C Cerboni,E Melluci,L Sibilio,A Zingoni (2011). Human Leukocyte antigen E contributes to protect tumor cells from lysis by natural killer cells.
A Harda,N Sekido,T Akahoshi,T Wada,N Mukaida,K Matsushima (1994). Essential involvement of interleukin -8 (IL-8) in acute inflammation.
Q Xu,L Wang,H Li (2012). Mesenchymal stem cells play a potential role in regulating the establishment and maintenance of epithelial -mesenchymal transition in MCF7 human breast cancer cells by paracrine and induced autocrine TGF-beta.
H Wang,J Wu,Y Zhang (2012). Transforming growth factor beta -induced epithelial -mesenchymal transition increases cancer stem -like cells in the PANC-1 cell line.
Qingqi Jiang,Sachiko Akashi,Kensuke Miyake,Howard Petty (2000). Cutting Edge: Lipopolysaccharide Induces Physical Proximity Between CD14 and Toll-Like Receptor 4 (TLR4) Prior to Nuclear Translocation of NF-κB.
Y Wang,L Li,X Guo (2012). Interleukin -6(IL-6) signaling regulates anchorage independent growth, proliferation, adhesion and invasion in human ovarian cancer cells.
E Tindall,G Severi,N Hoang (2012). Interleukin -6 promoter variants, prostate cancer risk and survival.
A Mancino,T Schioppa,P Larghi (2008). Divergent effects of hypoxia on dendritic cell functions.
Angela Elia,Paola Cappello,Maura Puppo,Tiziana Fraone,Cristina Vanni,Alessandra Eva,Tiziana Musso,Francesco Novelli,Luigi Varesio,Mirella Giovarelli (2010). Human dendritic cells differentiated in hypoxia down-modulate antigen uptake and change their chemokine expression profile.
Meixiang Yang,Chunhong Ma,Shuxun Liu,Qianqian Shao,Wenjuan Gao,Bingfeng Song,Jintang Sun,Qi Xie,Yun Zhang,Alei Feng,Yanguo Liu,Weixu Hu,Xun Qu (2010). HIF‐dependent induction of adenosine receptor A2b skews human dendritic cells to a Th2‐stimulating phenotype under hypoxia.
M Douglas,I Dmitry,Gabrilovich (2015). Myeloid derived suppressor cells in the tumor microenvironment; Expect the unexpected.
I Poschke,Y Mao,L Adamson,F Salazar-Onfray,G Masucci,R Kiessling (2011). Myeloid-derived suppressor cells impair the quality of dendritic cell vaccines.
B Mckenzie,R Kastelein,D Cua (2006). Understanding the IL-23-IL-17 immune pathway.
L Raffaghello,G Bianchi (2014). Myeloid-Derived Suppressor Cells and Tumor Growth. In Interaction of Immune and Cancer Cells.
C Diaz-Montero,Jim Finke,Alberto Montero (2014). Myeloid-Derived Suppressor Cells in Cancer: Therapeutic, Predictive, and Prognostic Implications.
Michele Teng,Daniel Andrews,Nicole Mclaughlin,Bianca Von Scheidt,Shin Ngiow,Andreas Möller,Geoffrey Hill,Yoichiro Iwakura,Martin Oft,Mark Smyth (2010). IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis.
W Sosroseno (2009). Effect of exogenous nitric oxide on murine splenic immune response induced by Aggregatibacteractinomycetemcomitans lipopolysaccharide.
R Bingisser (1998). Macrophagederivednitric oxide regulates T cell activation via reversible disruption of the Jak3/STAT5signaling pathway.
P Bobe (1999). Nitric oxide mediation of active immunosuppression associated with graft-versus hostreaction.
P Lejeune,P Lagadec,N Onier,D Pinard,H Ohshima,J Jeannin (1994). Nitric oxide involvement in tumor-induced immunosuppression..
A Mazzoni (2002). Myeloid suppressor lines inhibit T cell responses by an NO-dependent mechanism.
M Medot-Pirenne (1999). Augmentation of an antitumor CTL response in vivo by inhibition of suppressor macrophage nitric oxide.
K Sato (2007). Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells.
Olivier Harari,James Liao (2012). Inhibition of MHC II Gene Transcription by Nitric Oxide and Antioxidants.
Licia Rivoltini,Matteo Carrabba,Veronica Huber,Chiara Castelli,Luisa Novellino,Piero Dalerba,Roberta Mortarini,Giuseppe Arancia,Andrea Anichini,Stefano Fais,Giorgio Parmiani (2002). Immunity to cancer: attack and escape in T lymphocyte–tumor cell interaction.
C Bogdan (2011). Nitric oxide and the immune response.
S Morris (2002). Regulation of enzymes of the urea cycle and arginine metabolism.
Guoyao Wu,Sidney Morris (1998). Arginine metabolism: nitric oxide and beyond.
V Bronte (2003). IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing mice.
V Bronte (2005). Regulation of immune responses by L-arginine metabolism.
P Rodriguez (2008). Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives.
P Rodriguez (2004). Arginase -1 production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigenspecific T-cell responses.
S Nagaraj (2007). Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer.
P Gout (2011). A potent suppressor of lymphoma growth by inhibition of the x(c)-cystine transporter: anew action for an old drug.
Minu Srivastava,Pratima Sinha,Virginia Clements,Paulo Rodriguez,Suzanne Ostrand-Rosenberg (2010). Myeloid-Derived Suppressor Cells Inhibit T-Cell Activation by Depleting Cystine and Cysteine.
Anton Keskinov,Michael Shurin (2015). Myeloid regulatory cells in tumor spreading and metastasis.
S Ostrand -Rosenberg (2009). Myeloidderived suppressor cells: linking inflammation and cancer.
Evgeniy Eruslanov,Irina Daurkin,Javier Ortiz,Johannes Vieweg,Sergei Kusmartsev (2010). Pivotal Advance: Tumor-mediated induction of myeloid-derived suppressor cells and M2-polarized macrophages by altering intracellular PGE2 catabolism in myeloid cells.
D Legler (2010). Prostaglandin E2 at new glance; Novel insights in functional diversity offer therapeutic chances.
S Ostrand -Rosenberg (2012). Cross-talk between myeloid -derived suppressor cells (MDSC), macrophages, and dendritic cells enhances tumor -induced immune suppression.
N Dilek (2014). Myeloid -derived suppressor cells: mechanisms of action and recent advances in their role in transplant tolerance.
E Lo Manaco (2011). Human Leukocyte antigen E contributes to protect tumor cells from lysis by natural killer cells.
A Harda (1994). Essential involvement of interleukin -8 (IL-8) in acute inflammation.
Q Xu (2012). Mesenchymal stem cells play a potential role in regulating the establishment and maintenance of epithelial -mesenchymal transition in MCF7 human breast cancer cells by paracrine and induced autocrine TGF-beta.
Hui Wang,Junli Wu,Y Zhang,Xiaofeng Xue,Dong Tang,Zhongxu Yuan,Minyong Chen,Jishu Wei,Jingjing Zhang,Y Miao (2012). Transforming growth factor β-induced epithelial-mesenchymal transition increases cancer stem-like cells in the PANC-1 cell line.
Qingqi Jiang,Sachiko Akashi,Kensuke Miyake,Howard Petty (2000). Cutting Edge: Lipopolysaccharide Induces Physical Proximity Between CD14 and Toll-Like Receptor 4 (TLR4) Prior to Nuclear Translocation of NF-κB.
Y Wang (2012). Interleukin -6(IL-6) signaling regulates anchorage independent growth, proliferation, adhesion and invasion in human ovarian cancer cells.
E Tindall (2012). Interleukin -6 promoter variants, prostate cancer risk and survival.
A Mancino (2008). Divergent effects of hypoxia on dendritic cell functions.
A Elia (2010). Human dendritic cells differentiated in hypoxia down modulate antigen uptake and change their chemokine expression profile.
M Yang (2010). HIF-dependent induction of adenosine receptor A2b skews human dendritic cells to a Th2 -stimulating phenotype under hypoxia.
D Gabrilovich (2014). Mechanisms and functional significance of tumour-induced dendriticcell defects.
I Poschke,Y Mao,L Adamson,F Salazar-Onfray,G Masucci,R Kiessling (2011). Myeloid-derived suppressor cells impair the quality of dendritic cell vaccines.
B Mckenzie (2006). Understanding the IL-23-IL-17 immune pathway.
C Langrish (2005). IL-23 drives a pathogenic T cell population that induces autoimmune inflammation.
J Langowski (2006). IL-23 promotes tumour incidence and growth.
Michele Teng,Daniel Andrews,Nicole Mclaughlin,Bianca Von Scheidt,Shin Ngiow,Andreas Möller,Geoffrey Hill,Yoichiro Iwakura,Martin Oft,Mark Smyth (2010). IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis.
D Mittal (2014). New insights into cancer immunoediting and its three component phaseselimination, equilibrium and escape.

Download References

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Shrihari T.G. 2016. \u201cChronic Inflammation Induced Immunosuppression Tumor Microenvironment of Oral Cancer\u201d. Global Journal of Medical Research - J: Dentistry & Otolaryngology GJMR-J Volume 16 (GJMR Volume 16 Issue J2).

More Citation Formats

Select Citation Style:

Download Citation

GJMR Volume 16 Issue J2

Explore Journals Explore Volume Read This Issue

Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

Not Found

Classification

GJMR-J Classification NLMC Code: WU 158

Submission ReceivedDecember 10, 2015
Peer Review Double Blind
Handling Editor
Accepted January 1, 2016
Published January 15, 2016

Version of record

v1.2

Issue date

October 8, 2016

Language

Experiance in AR

Explore published articles in an immersive Augmented Reality environment. Our platform converts research papers into interactive 3D books, allowing readers to view and interact with content using AR and VR compatible devices.

View in VR

Read in 3D

Your published article is automatically converted into a realistic 3D book. Flip through pages and read research papers in a more engaging and interactive format.

View in 3D

Article Matrices

Total Score: 102

Country: India

Subject: Global Journal of Medical Research - J: Dentistry & Otolaryngology

Authors: Shrihari T.G, Ramesh DNSV (PhD/Dr. count: 0)

View Count (all-time): 153

Total Views (Real + Logic): 3773

Total Downloads (simulated): 1770

Publish Date: 2016 10, Sat

Monthly Totals (Real + Logic):

Month 1: 39 views
Month 2: 63 views
Month 3: 34 views
Month 4: 46 views
Month 5: 29 views
Month 6: 42 views
Month 7: 57 views
Month 8: 33 views
Month 9: 47 views
Month 10: 32 views
Month 11: 32 views
Month 12: 39 views
Month 13: 34 views
Month 14: 14 views
Month 15: 30 views
Month 16: 38 views
Month 17: 36 views
Month 18: 30 views
Month 19: 27 views
Month 20: 29 views
Month 21: 12 views
Month 22: 29 views
Month 23: 34 views
Month 24: 24 views
Month 25: 34 views
Month 26: 31 views
Month 27: 26 views
Month 28: 14 views
Month 29: 33 views
Month 30: 35 views
Month 31: 24 views
Month 32: 24 views
Month 33: 37 views
Month 34: 32 views
Month 35: 41 views
Month 36: 27 views
Month 37: 37 views
Month 38: 21 views
Month 39: 40 views
Month 40: 39 views
Month 41: 23 views
Month 42: 29 views
Month 43: 44 views
Month 44: 35 views
Month 45: 33 views
Month 46: 40 views
Month 47: 42 views
Month 48: 25 views
Month 49: 17 views
Month 50: 30 views
Month 51: 29 views
Month 52: 26 views
Month 53: 30 views
Month 54: 19 views
Month 55: 22 views
Month 56: 17 views
Month 57: 32 views
Month 58: 39 views
Month 59: 42 views
Month 60: 44 views
Month 61: 31 views
Month 62: 32 views
Month 63: 32 views
Month 64: 29 views
Month 65: 26 views
Month 66: 36 views
Month 67: 24 views
Month 68: 34 views
Month 69: 36 views
Month 70: 20 views
Month 71: 22 views
Month 72: 37 views
Month 73: 18 views
Month 74: 44 views
Month 75: 22 views
Month 76: 27 views
Month 77: 41 views
Month 78: 47 views
Month 79: 28 views
Month 80: 36 views
Month 81: 35 views
Month 82: 34 views
Month 83: 29 views
Month 84: 31 views
Month 85: 31 views
Month 86: 35 views
Month 87: 19 views
Month 88: 37 views
Month 89: 18 views
Month 90: 19 views
Month 91: 17 views
Month 92: 25 views
Month 93: 30 views
Month 94: 37 views
Month 95: 34 views
Month 96: 31 views
Month 97: 44 views
Month 98: 33 views
Month 99: 27 views
Month 100: 35 views
Month 101: 24 views
Month 102: 28 views
Month 103: 20 views
Month 104: 25 views
Month 105: 34 views
Month 106: 35 views
Month 107: 25 views
Month 108: 29 views
Month 109: 31 views
Month 110: 38 views
Month 111: 44 views
Month 112: 25 views
Month 113: 71 views
Month 114: 31 views
Month 115: 49 views

Total Views: 3773

Total Downloads: 1770

2026 Trends

Our website is actively being updated, and changes may occur frequently. Please clear your browser cache if needed. For feedback or error reporting, please email [email protected]