Circulating Progesterone Levels and Ongoing Pregnancy Rates in Controlled Ovarian Stimulation Cycles in Assisted Reproduction Techniques

Shailja Verma; Pratap Kumar

Circulating Progesterone Levels and Ongoing Pregnancy Rates in Controlled Ovarian Stimulation Cycles in Assisted Reproduction Techniques

Shailja Verma * §

Contact

Pratap Kumar

Contact

§ Kingston Hospital, NHS, London, UK

Circulating Progesterone Levels and Ongoing Pregnancy Rates in Controlled Ovarian Stimulation Cycles in Assisted Reproduction Techniques

Article Fingerprint

ReserarchID

MRE213T

Key Research Insights

Synthesized scholarly intelligence & interactive research assistant

Abstract

How can we prevent premature leutinization in our IVF cycles? To help find the solution a study designed with specific exclusion criteria in an assisted reproductive centre of a tertiary care hospital was designed. In a period of 2 years 100 patients were followed up prospectively. GnRH antagonist protocol was implemented for all recruits because of shorter duration of treatment and as it prevented hyperstimulation. Specific criteria was chosen for GnRH anatagonist initiation. Serum Progesterone measurements were used to predict premature leutinization. Electro-chemiluminiscence Immunoassay using COBAS 6000 used for the measurements. Three different groups analysed in above cohort and we concluded that despite of progesterone rise pregnancy outcome was unaffected. Why is the question answered in discussion.

References

22 Cites in Article

Reference Format

T Hoff,M Quigley,Ssc Yen (1983). Hormonal dynamics mid cycle: A reevaluation.
K Huang,E Muechler,K Schwarz,M Goggin,M Graham (1986). Serum progesterone levels in women treated with human menopausal gonadotropin and human chorionic gonadotropin for in vitro fertilization.
A Halbersztadt,J Pajak,P Nowicki,I Jałocha (2006). Implantation and antigenicity of human endometrium.
R Legro,B Ary,R Paulson,F Stanczyk,M Sauer (1993). Pregnancy: Premature luteinization as detected by elevated serum progesterone is associated with a higher pregnancy rate in donor oocyte in-vitro fertilization.
C Venetis,E Kolibianakis,E Papinkalaou (2007). Is progesterone elevation on the day of human chorionic gonadotrophin administration associated with probability of pregnancy in in vitro fertilization? A Survey Review And Meta-analysis.
J Younis,M Matilsky,O Radin,Ben (2001). Increased progesterone/estradiol ratio in the late follicular phase could be related to low ovarian reserve in in vitro fertilization -embryo transfer cycles with long gonadotropin -releasing hormone agonist.
William Schoolcraft,Eleanor Sinton,Terry Schlenker,David Huynh,Fredesminda Hamilton,David Meldrum (1991). Lower pregnancy rate with premature luteinization during pituitary suppression with leuprolide acetate.
Paulo Serafini,Bronte Stone,John Kerin,Joel Batzofin,Patrick Quinn,Richard Marrs (1988). Occurrence of a spontaneous luteinizing hormone surge in superovulated cycles—predictive value of serum progesterone.
M Dirnfeld,S Goldman,Y Gonen,M Koifman,A Lissak,H Abramovic (1993). A modest increase in serum progesterone levels on the day of human chorionic gonadotropin (hCG) administration may influence pregnancy rate and pregnancy loss in in vitro fertilization -embryo transfer patients.
Marcelle Cedars,Eric Surey,Fredesminda Hamilton,Phillip Lapolt,David Meldrum (1990). Leuprolide acetate lowers circulating bioactive luteinizing hormone and testosterone concentrations during ovarian stimulation for oocyte retrieval.
E Adashi,C Resnick,D 'ercol E Aj,M Svoboda,J Van Wyk (1985). Insulin-like growth factors are intraovarian regulators of granulosa cell growth and functions.
H Jones (1985). Factors influencing implantation and maintenence of pregnancy following embryo transfer.
N Spinks,O' Neill,C Collier,M Ryan,J (1987). Embryo derived platelet activating factor is essential in establishment of pregnancy in the mouse.
Kaylen Silverberg,William Burns,David Olive,Robert Riehl,Robert Schenken (1991). Serum Progesterone Levels Predict Success of<i>in Vitro</i>Fertilization/Embryo Transfer in Patients Stimulated with Leuprolide Acetate and Human Menopausal Gonadotropins*.
Michael Levy,David Smotrich,Eric Widra,Arthur Sagoskin,Denise Murray,Jerry Hall (1995). The predictive value of serum progesterone and 17-OH progesterone levels onin vitro fertilization outcome.
F Ubaldi,M Camus,Smitz,H Bennink,A Van Steirteghem,P Devroey,R ; Fanchin,C Righini,F Olivennes,A Ferreira,R De Ziegler D, Frydman (1996). Consequences of premature progesterone elevation on the outcome of in vitro fertilization: Insights into a controversy.
R Fleming (2008). Progesterone elevation on the day of hCG: methodological issues.
E Bosch,E Labarta,J Crespo,C Simón,J Remohí,J Jenkins,A Pellicer (2010). Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization: analysis of over 4000 cycles.
B Urman,C Alatas,S Aksoy,R Mercan,A Isiklar,B Balaban (1999). Elevated serum progesterone level on the day of hCG does not adversely affect implantation rates after intracytoplasmic sperm injection and embryo tranfer.
N Doldi,E Marsiglio,A Destafani,A Gessi,G Merati,A Ferrari (1999). Elevated serum progesterone on the day of HCG administration in IVF is associated with a higher pregnancy rate in polycystic ovary syndrome.
Tasuku Harada,Chieko Katagiri,Naruhisa Takao,Toshiko Toda,Yasuyuki Mio,Naoki Terakawa (1996). Altering the timing of human chorionic gonadotropin injection according to serum progesterone (P) concentrations improves embryo quality in cycles with subtle P rise.
Michael Harper (1992). 10 The implantation window.

Download References

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Shailja Verma, Pratap Kumar. 2017. "Circulating Progesterone Levels and Ongoing Pregnancy Rates in Controlled Ovarian Stimulation Cycles in Assisted Reproduction Techniques". Global Journal of Medical Research - E: Gynecology & Obstetrics GJMR-E Volume 17 (GJMR Volume 17 Issue E1).

More Citation Formats

Select Citation Style:

Download Citation

GJMR Volume 17 Issue E1

Explore Journals Explore Volume Read This Issue

Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

Not Found

Classification

GJMR-E Classification NLMC Code: WJ 190

Submission ReceivedDecember 9, 2016
Peer Review Double Blind
Handling Editor
Accepted January 3, 2017
Published January 15, 2017

Version of record

v1.2

Issue date

June 23, 2017

Language

English

Experiance in AR

Explore published articles in an immersive Augmented Reality environment. Our platform converts research papers into interactive 3D books, allowing readers to view and interact with content using AR and VR compatible devices.

View in VR

Read in 3D

Your published article is automatically converted into a realistic 3D book. Flip through pages and read research papers in a more engaging and interactive format.

View in 3D

Article Matrices

Total Score: 172

Country: United Kingdom

Subject: Global Journal of Medical Research

Authors: Shailja Verma, Pratap Kumar (PhD/Dr. count: 0)

View Count (all-time): 295

Total Views (Real + Logic): 1012

Total Downloads (simulated): 75

Publish Date: 2017 01, Sun

Monthly Totals (Real + Logic):

Month 1: 33 views
Month 2: 38 views
Month 3: 62 views
Month 4: 43 views
Month 5: 63 views
Month 6: 37 views
Month 7: 43 views
Month 8: 46 views
Month 9: 24 views
Month 10: 27 views
Month 11: 49 views
Month 12: 38 views
Month 13: 19 views
Month 14: 28 views
Month 15: 20 views
Month 16: 38 views
Month 17: 30 views
Month 18: 40 views
Month 19: 41 views
Month 20: 14 views
Month 21: 19 views
Month 22: 26 views
Month 23: 19 views
Month 24: 40 views
Month 25: 30 views
Month 26: 23 views
Month 27: 30 views
Month 28: 27 views
Month 29: 17 views
Month 30: 30 views
Month 31: 24 views
Month 32: 29 views
Month 33: 41 views
Month 34: 24 views
Month 35: 34 views
Month 36: 47 views
Month 37: 26 views
Month 38: 43 views
Month 39: 37 views
Month 40: 38 views
Month 41: 47 views
Month 42: 16 views
Month 43: 39 views
Month 44: 41 views
Month 45: 20 views
Month 46: 36 views
Month 47: 29 views
Month 48: 31 views
Month 49: 28 views
Month 50: 24 views
Month 51: 22 views
Month 52: 29 views
Month 53: 16 views
Month 54: 22 views
Month 55: 47 views
Month 56: 38 views
Month 57: 41 views
Month 58: 48 views
Month 59: 15 views
Month 60: 14 views
Month 61: 12 views
Month 62: 24 views
Month 63: 29 views
Month 64: 12 views
Month 65: 26 views
Month 66: 39 views
Month 67: 31 views
Month 68: 33 views
Month 69: 20 views
Month 70: 23 views
Month 71: 23 views
Month 72: 26 views
Month 73: 42 views
Month 74: 28 views
Month 75: 30 views
Month 76: 35 views
Month 77: 28 views
Month 78: 44 views
Month 79: 38 views
Month 80: 44 views
Month 81: 45 views
Month 82: 36 views
Month 83: 27 views
Month 84: 41 views
Month 85: 25 views
Month 86: 35 views
Month 87: 29 views
Month 88: 45 views
Month 89: 27 views
Month 90: 22 views
Month 91: 34 views
Month 92: 36 views
Month 93: 41 views
Month 94: 18 views
Month 95: 35 views
Month 96: 43 views
Month 97: 19 views
Month 98: 22 views
Month 99: 44 views
Month 100: 46 views
Month 101: 25 views
Month 102: 32 views
Month 103: 51 views
Month 104: 37 views
Month 105: 33 views
Month 106: 52 views
Month 107: 50 views
Month 108: 50 views
Month 109: 48 views
Month 110: 26 views
Month 111: 24 views
Month 112: 38 views
Month 113: 36 views
Month 114: 41 views
Month 115: 33 views
Month 116: 47 views
Month 117: 39 views

Total Views: 1K

Total Downloads: 75

All Trends