Colourimetric Assay of Atomoxetine Hydrochloride by Simple Aurum Coupling Reaction in Bulk and Tablet Dosage Form

1
B. Mohammed Ishaq
B. Mohammed Ishaq
2
Hindustan Abdul Ahad
Hindustan Abdul Ahad
3
Shaik Muneer
Shaik Muneer
4
S. Praveena
S. Praveena
1 Balaji College of Pharmacy

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Colourimetric Assay of Atomoxetine Hydrochloride by Simple Aurum Coupling Reaction in Bulk and Tablet  Dosage Form Banner
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Simple, rapid and sensitive spectrophotometric procedure was developed for the analysis of atomoxetine hydrochloride (ATH) in pure form as well as in pharmaceutical formulations. The method was based on the reaction of ATH with gold (III) chloride in the pH range 3.5-4.5 forming violet colored complex solution, showing absorption maxima at 550 nm. The linear plot indicates that Beer’s law is obeyed in the range of 5 -80 ΞΌg/ml of atomoxetine hydrochloride. The molar absorptivity and Sandell’s sensitivity are 3.77 x 103M and 0.0774 ΞΌg cm-2 respectively. The standard deviation of the method for ten determinations ATH is 9.9827 x 103. The correlation coefficient (r2) of the experimental data of the calibration plot is 0.9997. The effective range of concentration for accurate determination of ATH as ascertained from Ringbom’s plot and it is 10 -80 ΞΌg/ml.

8 Cites in Articles

References

  1. S Faraone,J Sergeant,C Gillberg,J Biederman (2003). Unknown Title.
  2. John Mullen,Richard Shugert,George Ponsler,Qimin Li,Bhaskar Sundaram,Heather Coales,Joseph Yakupkovic,Richard Lelacheur,William Wheeler,Frank Belas,John-Michael Sauer (2005). Simultaneous quantification of atomoxetine as well as its primary oxidative and O-glucuronide metabolites in human plasma and urine using liquid chromatography tandem mass spectrometry (LC/MS/MS).
  3. Z Hao-Jie,W Jun-Sheng,J Donovan,C Devane,B Gibson,J Markowitz (2007). Unknown Title.
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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

B. Mohammed Ishaq. 2014. \u201cColourimetric Assay of Atomoxetine Hydrochloride by Simple Aurum Coupling Reaction in Bulk and Tablet Dosage Form\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 13 (GJMR Volume 13 Issue B7): .

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Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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February 12, 2014

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English

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Simple, rapid and sensitive spectrophotometric procedure was developed for the analysis of atomoxetine hydrochloride (ATH) in pure form as well as in pharmaceutical formulations. The method was based on the reaction of ATH with gold (III) chloride in the pH range 3.5-4.5 forming violet colored complex solution, showing absorption maxima at 550 nm. The linear plot indicates that Beer’s law is obeyed in the range of 5 -80 ΞΌg/ml of atomoxetine hydrochloride. The molar absorptivity and Sandell’s sensitivity are 3.77 x 103M and 0.0774 ΞΌg cm-2 respectively. The standard deviation of the method for ten determinations ATH is 9.9827 x 103. The correlation coefficient (r2) of the experimental data of the calibration plot is 0.9997. The effective range of concentration for accurate determination of ATH as ascertained from Ringbom’s plot and it is 10 -80 ΞΌg/ml.

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Colourimetric Assay of Atomoxetine Hydrochloride by Simple Aurum Coupling Reaction in Bulk and Tablet Dosage Form

B. Mohammed Ishaq
B. Mohammed Ishaq Balaji College of Pharmacy
Hindustan Abdul Ahad
Hindustan Abdul Ahad
Shaik Muneer
Shaik Muneer
S. Praveena
S. Praveena

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