Colourimetric Assay of Atomoxetine Hydrochloride by Simple Aurum Coupling Reaction in Bulk and Tablet  Dosage Form

Colourimetric Assay of Atomoxetine Hydrochloride by Simple Aurum Coupling Reaction in Bulk and Tablet Dosage Form

B. Mohammed Ishaq

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Hindustan Abdul Ahad

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Shaik Muneer

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S. Praveena

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Jawaharlal Nehru Technological University Anantapur

Colourimetric Assay of Atomoxetine Hydrochloride by Simple Aurum Coupling Reaction in Bulk and Tablet Dosage Form

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Abstract

Simple, rapid and sensitive spectrophotometric procedure was developed for the analysis of atomoxetine hydrochloride (ATH) in pure form as well as in pharmaceutical formulations. The method was based on the reaction of ATH with gold (III) chloride in the pH range 3.5-4.5 forming violet colored complex solution, showing absorption maxima at 550 nm. The linear plot indicates that Beer’s law is obeyed in the range of 5 -80 μg/ml of atomoxetine hydrochloride. The molar absorptivity and Sandell’s sensitivity are 3.77 x 103M and 0.0774 μg cm-2 respectively. The standard deviation of the method for ten determinations ATH is 9.9827 x 103. The correlation coefficient (r2) of the experimental data of the calibration plot is 0.9997. The effective range of concentration for accurate determination of ATH as ascertained from Ringbom’s plot and it is 10 -80 μg/ml.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

B. Mohammed Ishaq. 2014. \u201cColourimetric Assay of Atomoxetine Hydrochloride by Simple Aurum Coupling Reaction in Bulk and Tablet Dosage Form\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 13 (GJMR Volume 13 Issue B7): .

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GJMR Volume 13 Issue B7
Pg. 71- 74

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

atomoxetine hydrochloride pharmaceutical formulations ringbom’s plot spectrophotometric

Submission ReceivedDecember 7, 2012
Peer Review Double Blind
Handling Editor
Accepted December 31, 2012
Published January 15, 2013

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Issue date

February 12, 2014

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Article Matrices

Total Score: 104

Country: India

Subject: Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine

Authors: B. Mohammed Ishaq, Hindustan Abdul Ahad, Shaik Muneer, S. Praveena (PhD/Dr. count: 0)

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