Comparative Analysis of Adverse Drug Reactions in Directly Observed Treatment Short Course (DOTS) in TB Patients

1
Md. Motiur Rahman
Md. Motiur Rahman
2
Ahmedullah Mishuk
Ahmedullah Mishuk
3
Shimul Halder
Shimul Halder
4
Abul Kalam Lutful Kabir
Abul Kalam Lutful Kabir
1 University of Dhaka

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This study describes the occurrences of adverse drug reactions (ADRs) caused by anti tubercular (TB) drugs employed in Directly Observed Treatment Short Course (DOTS) from ten years of ADR data (from 2002 to 2012) reported in various articles. The frequency of each type of ADR was analyzed and compared. A total of 10,219 patients were studied. Among them, 8,047 (78.75%) patients demonstrated positive responses to at least one type of ADR. Dermatological reactions predominated among the ADRs which occurred in 4389 (42.95%) patients followed by hepatotoxicity in 1634 (15.99%) cases. Female patients were more prone to ADRs as compared to the male patients. The occurrence of ADRs is mainly attributed to the combination therapy along with the prolonged medication period. A colossal amount of ADRs were observed during the study which must be monitored and managed properly throughout the DOTS therapy in order to prevent life-threatening harmful effects.

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No external funding was declared for this work.

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The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

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Not applicable for this article.

Md. Motiur Rahman. 2014. \u201cComparative Analysis of Adverse Drug Reactions in Directly Observed Treatment Short Course (DOTS) in TB Patients\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 13 (GJMR Volume 13 Issue B6): .

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Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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v1.2

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January 3, 2014

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English

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This study describes the occurrences of adverse drug reactions (ADRs) caused by anti tubercular (TB) drugs employed in Directly Observed Treatment Short Course (DOTS) from ten years of ADR data (from 2002 to 2012) reported in various articles. The frequency of each type of ADR was analyzed and compared. A total of 10,219 patients were studied. Among them, 8,047 (78.75%) patients demonstrated positive responses to at least one type of ADR. Dermatological reactions predominated among the ADRs which occurred in 4389 (42.95%) patients followed by hepatotoxicity in 1634 (15.99%) cases. Female patients were more prone to ADRs as compared to the male patients. The occurrence of ADRs is mainly attributed to the combination therapy along with the prolonged medication period. A colossal amount of ADRs were observed during the study which must be monitored and managed properly throughout the DOTS therapy in order to prevent life-threatening harmful effects.

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Comparative Analysis of Adverse Drug Reactions in Directly Observed Treatment Short Course (DOTS) in TB Patients

Md. Motiur Rahman
Md. Motiur Rahman Pabna University of Science & Technology (PUST)
Ahmedullah Mishuk
Ahmedullah Mishuk
Shimul Halder
Shimul Halder
Abul Kalam Lutful Kabir
Abul Kalam Lutful Kabir

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