Comparative Hepatoprotective Activities of Selected Indian Medicinal Plants

mohdfazil ahamed
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Comparative Hepatoprotective Activities of Selected Indian Medicinal Plants

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Abstract

The present study deals with comparative evaluation of hepatoprotective activities of Melia azedarach Linn, Catharanthus Rosea and Brassica oleracea L.var.capitata ethanolic leaves extracts against simvastatin induced hepatotoxicity in rats. Hepatotoxicity in rats was induced by simvastatin (20 mg/kg p.o. for 30 days) and the protective effect of Melia azedarach Linn, Catharanthus Rosea and Brassica oleracea L.var.capitata (300 mg/kg/p.o. and 500 mg/kg/p.o.) was identified by estimating marker enzymes. Simvastatin treated rats shows significant changes in biochemical parameters i.e. increases in Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), Alanine Phosphatase (ALP), Serum bilirubin and decrease in Total proteins content, which were restored towards normalization in extracts treated rats. The results revealed that the ethanolic extracts of Melia azedarach Linn, and Brassica oleracea L.var.capitata (300 mg/kg/p.o. and 500 mg/kg/p.o.) exhibited potent hepatoprotective activity than Catharanthus Rosea. The hepatoprotective effect of extracts was further confirmed by histopathological studies of liver, which shows normal architecture of liver cell than compared with hepatotoxicant group. Possible mechanism for hepatoprotective activity may be due to free radical scavenging potential in extracts.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

mohdfazil ahamed. 1970. "Comparative Hepatoprotective Activities of Selected Indian Medicinal Plants". Global Journal of Medical Research, Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 13 (GJMR Volume 13 Issue B2).

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords
capitatacatharanthus rosea and brassica oleracea Lhepatoprotective activity and simvastatinmelia azedarach linnvar
Classification
GJMR-B Classification NLMC Code: WB 55.A9
  • Submission ReceivedDecember 13, 2012
  • Peer Review Double Blind
    Handling Editor
  • Accepted January 2, 2013
  • Published January 15, 2013
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English
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Comparative Hepatoprotective Activities of Selected Indian Medicinal Plants

mohdfazil ahamed
mohdfazil ahamed NIZAM INSTITUTE OF PHARMACY
  • Submission ReceivedDecember 13, 2012
  • Peer Review Double Blind
    Handling Editor
  • Accepted January 2, 2013
  • Published January 15, 2013