Comparative Studies of the Effect of Diazepam and Magnesium Sulphate on Motor Coordination and Seizures in 4-Aminopyridine Induced Swiss Mice

1
Kebe, E. Obeten
Kebe, E. Obeten
2
Kebe
Kebe
3
E. Obeten
E. Obeten
4
Charles
Charles
5
C. Mfem
C. Mfem
6
Usun
Usun
7
O. Usun
O. Usun
8
Gabriel
Gabriel
9
Udo-AffahKebe
Udo-AffahKebe
10
Udo-Affah
Udo-Affah
1 University of Calabar, Calabar

Send Message

To: Author

GJSFR Volume 16 Issue C1

Article Fingerprint

ReserarchID

E204H

Comparative Studies of the Effect of Diazepam and Magnesium Sulphate on Motor Coordination and Seizures in 4-Aminopyridine Induced Swiss Mice Banner
  • English
  • Afrikaans
  • Albanian
  • Amharic
  • Arabic
  • Armenian
  • Azerbaijani
  • Basque
  • Belarusian
  • Bengali
  • Bosnian
  • Bulgarian
  • Catalan
  • Cebuano
  • Chichewa
  • Chinese (Simplified)
  • Chinese (Traditional)
  • Corsican
  • Croatian
  • Czech
  • Danish
  • Dutch
  • Esperanto
  • Estonian
  • Filipino
  • Finnish
  • French
  • Frisian
  • Galician
  • Georgian
  • German
  • Greek
  • Gujarati
  • Haitian Creole
  • Hausa
  • Hawaiian
  • Hebrew
  • Hindi
  • Hmong
  • Hungarian
  • Icelandic
  • Igbo
  • Indonesian
  • Irish
  • Italian
  • Japanese
  • Javanese
  • Kannada
  • Kazakh
  • Khmer
  • Korean
  • Kurdish (Kurmanji)
  • Kyrgyz
  • Lao
  • Latin
  • Latvian
  • Lithuanian
  • Luxembourgish
  • Macedonian
  • Malagasy
  • Malay
  • Malayalam
  • Maltese
  • Maori
  • Marathi
  • Mongolian
  • Myanmar (Burmese)
  • Nepali
  • Norwegian
  • Pashto
  • Persian
  • Polish
  • Portuguese
  • Punjabi
  • Romanian
  • Russian
  • Samoan
  • Scots Gaelic
  • Serbian
  • Sesotho
  • Shona
  • Sindhi
  • Sinhala
  • Slovak
  • Slovenian
  • Somali
  • Spanish
  • Sundanese
  • Swahili
  • Swedish
  • Tajik
  • Tamil
  • Telugu
  • Thai
  • Turkish
  • Ukrainian
  • Urdu
  • Uzbek
  • Vietnamese
  • Welsh
  • Xhosa
  • Yiddish
  • Yoruba
  • Zulu

The comparative effect of Diazepam and magnesium sulphate on motor coordination and seizures in mice induced with 4-Aminopyridine (4-AP) was studied. Thirty six (36) Swiss white male and female mice were randomly assigned into three (3) groups of six (6) animals each for seizure and beam walking test. Group one animals served as control group and were given normal saline intreperitoneally. Group two animals were given Magnesium sulphate (M.S) (4.5mg/kg) intraperitoneally. Group three (DZP) animals receieved Diazepam (DZP) (2mg/kg) intraperitoneally for the beam walking test. While for the seizure tests, Group one (4-AP) served as control and were given 4-Aminopyridine (4-AP) (13.3mg/kg) only, intraperitoneally. Group two (M.S) animals were given 4-Aminopyridine and Magnesium sulphate (M.S) intraperitoneally 15 minutes before inducing epilepsy with 4-AP. Group three (DZP) animals received 4-Aminopyridine and Diazepam intraperitoneally 15 minutes before inducing epilepsy with 4-AP. Anti-epileptic effect was assessed by scoring the onset of both tonic and clonic seizures.

16 Cites in Articles

References

  1. D Davey,I (1988). The classification of Hypertensive Disorder of pregnancy.
  2. Labib Ghulmiyyah,Baha Sibai (2012). Maternal Mortality From Preeclampsia/Eclampsia.
  3. R Gifford (1990). National high blood pressure education program working group report on high blood pressure in pregnancy.
  4. J Hutton,D James,G Stirrat,K Douglas,C Redman (1992). Management of severe pre‐eclampsia and eclampsia by UK consultants.
  5. S Judge,C &bever (2006). Potassium channel blockers in multiple sclerosis.
  6. Sanford Kimmel,Karen Ratliff-Schaub (2011). Growth and Development.
  7. L Mandrioli,M,M,R (2008). Benzodiazepine metabolism.
  8. N Matar,W Jin,H Wrubel (2009). Zonisamide block cloned human T-type voltagegated calcium channels.
  9. M Mushambi,A Halligan,K Williamson (1996). Recent developments in the pathophysiology and management of pre-eclampsia.
  10. Jean Boutrais (2012). Cures salées, cures natronées pastorales en savanes centrafricaines.
  11. J Riss,J Cloyd,J Gates,S Collins (2008). Benzodiazepines in epilepsy: pharmacology and pharmacokinetics.
  12. M Rogawski,W &loscher (2004). The neuro biology of antiepileptic drugs.
  13. A Solari (2001). Aminopyridines for symptomatic treatment in multiple sclerosis.
  14. B Szewczyk,E Poleszak,M Sowa-Kucma (2008). Antidepressant activity of Zinc and Magnesium in view of the current hypotheses of antidepressant action.
  15. A Tasman,J Lieberman (2006). Handbook of psychiatric drugs.
  16. Who (2013). Model List of Essential Medicines.

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

Kebe, E. Obeten. 2016. \u201cComparative Studies of the Effect of Diazepam and Magnesium Sulphate on Motor Coordination and Seizures in 4-Aminopyridine Induced Swiss Mice\u201d. Global Journal of Science Frontier Research - C: Biological Science GJSFR-C Volume 16 (GJSFR Volume 16 Issue C1): .

Download Citation

Journal Specifications

Crossref Journal DOI 10.17406/GJSFR

Print ISSN 0975-5896

e-ISSN 2249-4626

Keywords
Classification
GJSFR-C Classification: FOR Code: 069999
Version of record

v1.2

Issue date

April 26, 2016

Language

English

Experiance in AR

The methods for personal identification and authentication are no exception.

Read in 3D

The methods for personal identification and authentication are no exception.

Article Matrices
Total Views: 3864
Total Downloads: 1967
2026 Trends
Research Identity (RIN)
Related Research

Published Article

The comparative effect of Diazepam and magnesium sulphate on motor coordination and seizures in mice induced with 4-Aminopyridine (4-AP) was studied. Thirty six (36) Swiss white male and female mice were randomly assigned into three (3) groups of six (6) animals each for seizure and beam walking test. Group one animals served as control group and were given normal saline intreperitoneally. Group two animals were given Magnesium sulphate (M.S) (4.5mg/kg) intraperitoneally. Group three (DZP) animals receieved Diazepam (DZP) (2mg/kg) intraperitoneally for the beam walking test. While for the seizure tests, Group one (4-AP) served as control and were given 4-Aminopyridine (4-AP) (13.3mg/kg) only, intraperitoneally. Group two (M.S) animals were given 4-Aminopyridine and Magnesium sulphate (M.S) intraperitoneally 15 minutes before inducing epilepsy with 4-AP. Group three (DZP) animals received 4-Aminopyridine and Diazepam intraperitoneally 15 minutes before inducing epilepsy with 4-AP. Anti-epileptic effect was assessed by scoring the onset of both tonic and clonic seizures.

Our website is actively being updated, and changes may occur frequently. Please clear your browser cache if needed. For feedback or error reporting, please email [email protected]
×

This Page is Under Development

We are currently updating this article page for a better experience.

Request Access

Please fill out the form below to request access to this research paper. Your request will be reviewed by the editorial or author team.
X

Quote and Order Details

Contact Person

Invoice Address

Notes or Comments

This is the heading

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Ut elit tellus, luctus nec ullamcorper mattis, pulvinar dapibus leo.

High-quality academic research articles on global topics and journals.

Comparative Studies of the Effect of Diazepam and Magnesium Sulphate on Motor Coordination and Seizures in 4-Aminopyridine Induced Swiss Mice

Kebe
Kebe
E. Obeten
E. Obeten
Charles
Charles
C. Mfem
C. Mfem
Usun
Usun
O. Usun
O. Usun
Gabriel
Gabriel
Udo-AffahKebe
Udo-AffahKebe
E. Obeten
E. Obeten
Charles
Charles
C. Mfem
C. Mfem
Usun
Usun
O. Usun
O. Usun
Gabriel
Gabriel
Udo-Affah
Udo-Affah

Research Journals