Comparative Studies of the Effect of Diazepam and Magnesium Sulphate on Motor Coordination and Seizures in 4-Aminopyridine Induced Swiss Mice

Comparative Studies of the Effect of Diazepam and Magnesium Sulphate on Motor Coordination and Seizures in 4-Aminopyridine Induced Swiss Mice

Article ID

E204H

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Comparative Studies of the Effect of Diazepam and Magnesium Sulphate on Motor Coordination and Seizures in 4-Aminopyridine Induced Swiss Mice

Kebe

E. Obeten

Charles

C. Mfem

Usun

O. Usun

Gabriel

Udo-AffahKebe

E. Obeten

Charles

C. Mfem

Usun

O. Usun

Gabriel

Udo-Affah

DOI

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Abstract

The comparative effect of Diazepam and magnesium sulphate on motor coordination and seizures in mice induced with 4-Aminopyridine (4-AP) was studied. Thirty six (36) Swiss white male and female mice were randomly assigned into three (3) groups of six (6) animals each for seizure and beam walking test. Group one animals served as control group and were given normal saline intreperitoneally. Group two animals were given Magnesium sulphate (M.S) (4.5mg/kg) intraperitoneally. Group three (DZP) animals receieved Diazepam (DZP) (2mg/kg) intraperitoneally for the beam walking test. While for the seizure tests, Group one (4-AP) served as control and were given 4-Aminopyridine (4-AP) (13.3mg/kg) only, intraperitoneally. Group two (M.S) animals were given 4-Aminopyridine and Magnesium sulphate (M.S) intraperitoneally 15 minutes before inducing epilepsy with 4-AP. Group three (DZP) animals received 4-Aminopyridine and Diazepam intraperitoneally 15 minutes before inducing epilepsy with 4-AP. Anti-epileptic effect was assessed by scoring the onset of both tonic and clonic seizures.

Comparative Studies of the Effect of Diazepam and Magnesium Sulphate on Motor Coordination and Seizures in 4-Aminopyridine Induced Swiss Mice

Authors

Kebe

E. Obeten

Charles

C. Mfem

Usun

O. Usun

Gabriel

Udo-AffahKebe

E. Obeten

Charles

C. Mfem

Usun

O. Usun

Gabriel

Udo-Affah

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How to Cite

Kebe, E. Obeten. 2016. “. Global Journal of Science Frontier Research – C: Biological Science GJSFR-C Volume 16 (GJSFR Volume 16 Issue C1): .

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Journal Specifications

Crossref Journal DOI 10.17406/GJSFR

Print ISSN 0975-5896

e-ISSN 2249-4626

GJSFR Volume 16 Issue C1
Pg. 1- 12

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Classification

GJSFR-C Classification: FOR Code: 069999

Submission Received February 12, 2016
Accepted March 4, 2016
Published March 14, 2016

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Article Matrices

Total Score: 115

Country: Nigeria

Subject: Global Journal of Science Frontier Research - C: Biological Science

Authors: Kebe, E. Obeten, Charles, C. Mfem, Usun, O. Usun, Gabriel, Udo-AffahKebe, E. Obeten, Charles, C. Mfem, Usun, O. Usun, Gabriel, Udo-Affah (PhD/Dr. count: 0)

View Count (all-time): 140

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Publish Date: 2016 04, Tue

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Total Views: 3816

Total Downloads: 2035

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