Comparative Study of Diallyl-Disulphide and Dipropyl-Disulphide in Experimental Atherosclerosis

1
Dr. Govindaswamy .K.S.
Dr. Govindaswamy .K.S.
2
Kashinath .R .T.
Kashinath .R .T.
3
Basavaraj B. Devaranavadagi
Basavaraj B. Devaranavadagi
4
Nagendra.S.
Nagendra.S.
1 Rajiv Gandhi University of Health Sciences

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Diallyl disulphide, the principle organosulphur compound of garlic oil, is known to possess many clinical beneficial effects, but its overuse or abuse has been reported to cause certain harmful side effects due to its possible metabolite acrolein. It was thought that the disulphide nature of diallyl disulphide is responsible for its hypolipidemic effect and the unsaturation may be for its toxic effects. Recently few synthetic disulphides are successfully employed in experimentally induced hyperlipidemia. The present study was under taken to compare the hypolipidemic as well as toxic effects of saturated disulphide, Dipropyl disulphide with Diallyl disulphide. The atherogenic diet fed male albino rats were given orally 100mg/kg body weight of disulphide (DADS or DPDS) for 60 days, later the rats were sacrificed and the plasma lipid profile, glycoproteins, calcium and transaminases were estimated. The aortic homogenates were employed for the estimation of thiobarbituric acid reactive substances and total sulphhydryl group. The results indicate a significant hypolipidemic effect with dipropyl disulphide with a comparative lower toxic side effect. It is concluded that DPDS is much safer and equally good hypolipidemic agent in experimentally induced hyperlipidemia in albino rats.

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No external funding was declared for this work.

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The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

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Not applicable for this article.

Dr. Govindaswamy .K.S.. 2013. \u201cComparative Study of Diallyl-Disulphide and Dipropyl-Disulphide in Experimental Atherosclerosis\u201d. Global Journal of Medical Research - K: Interdisciplinary GJMR-K Volume 13 (GJMR Volume 13 Issue K2): .

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Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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May 2, 2013

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English

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Diallyl disulphide, the principle organosulphur compound of garlic oil, is known to possess many clinical beneficial effects, but its overuse or abuse has been reported to cause certain harmful side effects due to its possible metabolite acrolein. It was thought that the disulphide nature of diallyl disulphide is responsible for its hypolipidemic effect and the unsaturation may be for its toxic effects. Recently few synthetic disulphides are successfully employed in experimentally induced hyperlipidemia. The present study was under taken to compare the hypolipidemic as well as toxic effects of saturated disulphide, Dipropyl disulphide with Diallyl disulphide. The atherogenic diet fed male albino rats were given orally 100mg/kg body weight of disulphide (DADS or DPDS) for 60 days, later the rats were sacrificed and the plasma lipid profile, glycoproteins, calcium and transaminases were estimated. The aortic homogenates were employed for the estimation of thiobarbituric acid reactive substances and total sulphhydryl group. The results indicate a significant hypolipidemic effect with dipropyl disulphide with a comparative lower toxic side effect. It is concluded that DPDS is much safer and equally good hypolipidemic agent in experimentally induced hyperlipidemia in albino rats.

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Comparative Study of Diallyl-Disulphide and Dipropyl-Disulphide in Experimental Atherosclerosis

Dr. Govindaswamy .K.S.
Dr. Govindaswamy .K.S. Rajiv Gandhi University of Health Sciences
Kashinath .R .T.
Kashinath .R .T.
Basavaraj B. Devaranavadagi
Basavaraj B. Devaranavadagi
Nagendra.S.
Nagendra.S.

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