Comparative Study of Diallyl-Disulphide and Dipropyl-Disulphide in Experimental Atherosclerosis

Dr. Govindaswamy .K.S.
Dr. Govindaswamy .K.S. * §
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nagendra subbaiah
nagendra subbaiah
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Basavaraj B. Devaranavadagi
Basavaraj B. Devaranavadagi
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§ Rajiv Gandhi University of Health Sciences

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Comparative Study of Diallyl-Disulphide and Dipropyl-Disulphide in Experimental Atherosclerosis

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Abstract

Diallyl disulphide, the principle organosulphur compound of garlic oil, is known to possess many clinical beneficial effects, but its overuse or abuse has been reported to cause certain harmful side effects due to its possible metabolite acrolein. It was thought that the disulphide nature of diallyl disulphide is responsible for its hypolipidemic effect and the unsaturation may be for its toxic effects. Recently few synthetic disulphides are successfully employed in experimentally induced hyperlipidemia. The present study was under taken to compare the hypolipidemic as well as toxic effects of saturated disulphide, Dipropyl disulphide with Diallyl disulphide. The atherogenic diet fed male albino rats were given orally 100mg/kg body weight of disulphide (DADS or DPDS) for 60 days, later the rats were sacrificed and the plasma lipid profile, glycoproteins, calcium and transaminases were estimated. The aortic homogenates were employed for the estimation of thiobarbituric acid reactive substances and total sulphhydryl group. The results indicate a significant hypolipidemic effect with dipropyl disulphide with a comparative lower toxic side effect. It is concluded that DPDS is much safer and equally good hypolipidemic agent in experimentally induced hyperlipidemia in albino rats.

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  24. C Stevinson,M Pittler,Ernst (2000). TABLE8TocolDerivativeContentinCerealGrainsTocolderivatives ( m g / 100g ) aGrainsa -T a -T -3 1 3 -T I 3 -T -3 y -T y -T -3 6 -T 6 -T -3 TotalRef . Barley0 . 2 -0 . 4 1 . 1 -1 . 3 0 . 0 4 -0 . 4 0 . 3 -0 . 7 0 . 0 3 -0 . 5 0 . 2 0 . 0 1 -0 . 040 . 1 6 < 5 . 030 . 4 1 . 3 0 . 3 0 . 7 0 . 050 . 2 0 . 1 -8 9 0 . 5 1 . 3 0 . 020 . 7 0 . 070 . 8 0 . 020 . 0750 . 3 1 . 6 < 0 . 1 0 . 6 0 . 1 0 . 6 < 0 . 1 -9 0Genotype0 . 7 2 -1 . 162 . 3 8 -4 . 300 . 0 5 -0 . 130 . 3 1 -1 . 210 . 0 4 -0 . 120 . 2 4 -0 . 960 . 0 4 -0 . 140 . 0 2 -0 . 204 . 2 2 -8 . 0091Location0 . 8 8 -1 . 113 . 0 5 -3 . 630 . 002 -0 . 190 . 6 7 -0 . 750 . 070 . 5 0 -0 . 560 . 0 4 -0 . 130 . 0 7 -0 . 115 . 6 7 -6 . 0891Malt1 . 003 . 070 . 140 . 460 . 040 . 390 . 040 . 065 . 292Spentgrain2 . 029 . 210 . 311 . 600 . 091 . 760 . 120 . 1815 . 392Corn0 . 6 -2 . 1 0 . 2 -0 . 5 -0 . 5 -1 . 1 3 -0 . 6 0 . 2 0 . 4 3 . 8 0 . 5tr890 . 1 -2 . 3 0 . 3 -0 . 7 1 . 1 -7 . 1 0 . 1 -1 . 9 2 . 6 -1 0 . 29Millet0 . 05tr1 . 3 0 . 489 -0 . 1 < 0 . 1 0 . 1 1 . 7 < 0 . 1 0 . 690Bulrushmillet0 . 1 3 -5 . 540 . 530 . 080 . 25Foxtailmillet0 . 190 . 040 . 042 . 780 . 065Fingermillet0 . 320 . 050 . 031 . 7 6 -5 Pearlmillet0 . 041 . 5 -0 . 355 -O ats0 . 3 -1 . 7 0 . 7 -1 . 1 0 . 1 -0 . 2 0 . 1 -0 . 3 0 . 3 -3 0 . 7 0 . 7 0 . 2 0 . 1 0 . 3 -8 9 1 . 3 -4 . 0 0 . 2 -6 . 3 0 . 3 -0 . 5 0 . 3 -1 . 1 0 . 7 -6 . 1 0 . 910 . 140 . 321 . 3 -3 . 011Genotype0 . 5 5 -0 . 960 . 9 1 -1 . 860 . 0 7 -0 . 130 . 0 5 -0 . 150 . 0 5 -0 . 130 . 0 0 -0 . 061 . 9 -3 . 091Location0 . 7 2 -0 . 961 . 1 7 -1 . 830 . 0 7 -0 . 110 . 0 5 -0 . 140 . 0 8 -0 . 110 . 0 1 -0 . 032 . 1 -3 . 191RiceBrownrice0 . 6 0 . 4 0 . 1 < 0 . 010 . 1 0 . 7 < 0 . 190Polishedrice < 0 . 1 0 . 1 < 0 . 1 < 0 . 1 < 0 . 1 0 . 3 < 0 . 190Milledrice0 . 0 5 -0 . 3 0 . 2 -0 . 5 0 . 1 -0 . 3 -< 0 . 0440 . 3tr0 . 3 0 . 5 0 . 04890 . 060 . 080 . 260 . 020 . 025 -R ye0 . 5 -1 . 8 0 . 7 -1 . 5 0 . 3 -0 . 7 0 . 8 -0 . 9 0 . 6 -3 0 . 8 1 . 3 0 . 4 0 . 9 0 . 689Flour0 . 6 0 . 4 0 . 3 0 . 6 -9 0Meal1 . 0 1 . 4 0 . 3 1 . 190Sorghum0 . 081 . 155Triticale0 . 911 . 030 . 301 . 515Winter0 . 7 -0 . 9593Spring1 . 3 5 -1 . 4593 -W heat1 . 0 0 . 2 0 . 4 1 . 9 -5 0 . 9 -1 . 8 0 . 3 -0 . 7 2 . 5 -3 . 6 4 . 9 -5 . 831 . 0 0 . 4 0 . 9 2 . 5 0 . 0889aTocopherolsincludea -T , 0 -T , y -T , and5 -T , andtocotrienolsincludea -T -3 , 0 -T -3 , y -T -3 , andS -T -3 . ( -) denotedatanotreported ..
  25. (2000). TABLE8TocolDerivativeContentinCerealGrainsTocolderivatives ( m g / 100g ) aGrainsa -T a -T -3 1 3 -T I 3 -T -3 y -T y -T -3 6 -T 6 -T -3 TotalRef . Barley0 . 2 -0 . 4 1 . 1 -1 . 3 0 . 0 4 -0 . 4 0 . 3 -0 . 7 0 . 0 3 -0 . 5 0 . 2 0 . 0 1 -0 . 040 . 1 6 < 5 . 030 . 4 1 . 3 0 . 3 0 . 7 0 . 050 . 2 0 . 1 -8 9 0 . 5 1 . 3 0 . 020 . 7 0 . 070 . 8 0 . 020 . 0750 . 3 1 . 6 < 0 . 1 0 . 6 0 . 1 0 . 6 < 0 . 1 -9 0Genotype0 . 7 2 -1 . 162 . 3 8 -4 . 300 . 0 5 -0 . 130 . 3 1 -1 . 210 . 0 4 -0 . 120 . 2 4 -0 . 960 . 0 4 -0 . 140 . 0 2 -0 . 204 . 2 2 -8 . 0091Location0 . 8 8 -1 . 113 . 0 5 -3 . 630 . 002 -0 . 190 . 6 7 -0 . 750 . 070 . 5 0 -0 . 560 . 0 4 -0 . 130 . 0 7 -0 . 115 . 6 7 -6 . 0891Malt1 . 003 . 070 . 140 . 460 . 040 . 390 . 040 . 065 . 292Spentgrain2 . 029 . 210 . 311 . 600 . 091 . 760 . 120 . 1815 . 392Corn0 . 6 -2 . 1 0 . 2 -0 . 5 -0 . 5 -1 . 1 3 -0 . 6 0 . 2 0 . 4 3 . 8 0 . 5tr890 . 1 -2 . 3 0 . 3 -0 . 7 1 . 1 -7 . 1 0 . 1 -1 . 9 2 . 6 -1 0 . 29Millet0 . 05tr1 . 3 0 . 489 -0 . 1 < 0 . 1 0 . 1 1 . 7 < 0 . 1 0 . 690Bulrushmillet0 . 1 3 -5 . 540 . 530 . 080 . 25Foxtailmillet0 . 190 . 040 . 042 . 780 . 065Fingermillet0 . 320 . 050 . 031 . 7 6 -5 Pearlmillet0 . 041 . 5 -0 . 355 -O ats0 . 3 -1 . 7 0 . 7 -1 . 1 0 . 1 -0 . 2 0 . 1 -0 . 3 0 . 3 -3 0 . 7 0 . 7 0 . 2 0 . 1 0 . 3 -8 9 1 . 3 -4 . 0 0 . 2 -6 . 3 0 . 3 -0 . 5 0 . 3 -1 . 1 0 . 7 -6 . 1 0 . 910 . 140 . 321 . 3 -3 . 011Genotype0 . 5 5 -0 . 960 . 9 1 -1 . 860 . 0 7 -0 . 130 . 0 5 -0 . 150 . 0 5 -0 . 130 . 0 0 -0 . 061 . 9 -3 . 091Location0 . 7 2 -0 . 961 . 1 7 -1 . 830 . 0 7 -0 . 110 . 0 5 -0 . 140 . 0 8 -0 . 110 . 0 1 -0 . 032 . 1 -3 . 191RiceBrownrice0 . 6 0 . 4 0 . 1 < 0 . 010 . 1 0 . 7 < 0 . 190Polishedrice < 0 . 1 0 . 1 < 0 . 1 < 0 . 1 < 0 . 1 0 . 3 < 0 . 190Milledrice0 . 0 5 -0 . 3 0 . 2 -0 . 5 0 . 1 -0 . 3 -< 0 . 0440 . 3tr0 . 3 0 . 5 0 . 04890 . 060 . 080 . 260 . 020 . 025 -R ye0 . 5 -1 . 8 0 . 7 -1 . 5 0 . 3 -0 . 7 0 . 8 -0 . 9 0 . 6 -3 0 . 8 1 . 3 0 . 4 0 . 9 0 . 689Flour0 . 6 0 . 4 0 . 3 0 . 6 -9 0Meal1 . 0 1 . 4 0 . 3 1 . 190Sorghum0 . 081 . 155Triticale0 . 911 . 030 . 301 . 515Winter0 . 7 -0 . 9593Spring1 . 3 5 -1 . 4593 -W heat1 . 0 0 . 2 0 . 4 1 . 9 -5 0 . 9 -1 . 8 0 . 3 -0 . 7 2 . 5 -3 . 6 4 . 9 -5 . 831 . 0 0 . 4 0 . 9 2 . 5 0 . 0889aTocopherolsincludea -T , 0 -T , y -T , and5 -T , andtocotrienolsincludea -T -3 , 0 -T -3 , y -T -3 , andS -T -3 . ( -) denotedatanotreported ..
  26. Unknown Title.
  27. (2000). TABLE8TocolDerivativeContentinCerealGrainsTocolderivatives ( m g / 100g ) aGrainsa -T a -T -3 1 3 -T I 3 -T -3 y -T y -T -3 6 -T 6 -T -3 TotalRef . Barley0 . 2 -0 . 4 1 . 1 -1 . 3 0 . 0 4 -0 . 4 0 . 3 -0 . 7 0 . 0 3 -0 . 5 0 . 2 0 . 0 1 -0 . 040 . 1 6 < 5 . 030 . 4 1 . 3 0 . 3 0 . 7 0 . 050 . 2 0 . 1 -8 9 0 . 5 1 . 3 0 . 020 . 7 0 . 070 . 8 0 . 020 . 0750 . 3 1 . 6 < 0 . 1 0 . 6 0 . 1 0 . 6 < 0 . 1 -9 0Genotype0 . 7 2 -1 . 162 . 3 8 -4 . 300 . 0 5 -0 . 130 . 3 1 -1 . 210 . 0 4 -0 . 120 . 2 4 -0 . 960 . 0 4 -0 . 140 . 0 2 -0 . 204 . 2 2 -8 . 0091Location0 . 8 8 -1 . 113 . 0 5 -3 . 630 . 002 -0 . 190 . 6 7 -0 . 750 . 070 . 5 0 -0 . 560 . 0 4 -0 . 130 . 0 7 -0 . 115 . 6 7 -6 . 0891Malt1 . 003 . 070 . 140 . 460 . 040 . 390 . 040 . 065 . 292Spentgrain2 . 029 . 210 . 311 . 600 . 091 . 760 . 120 . 1815 . 392Corn0 . 6 -2 . 1 0 . 2 -0 . 5 -0 . 5 -1 . 1 3 -0 . 6 0 . 2 0 . 4 3 . 8 0 . 5tr890 . 1 -2 . 3 0 . 3 -0 . 7 1 . 1 -7 . 1 0 . 1 -1 . 9 2 . 6 -1 0 . 29Millet0 . 05tr1 . 3 0 . 489 -0 . 1 < 0 . 1 0 . 1 1 . 7 < 0 . 1 0 . 690Bulrushmillet0 . 1 3 -5 . 540 . 530 . 080 . 25Foxtailmillet0 . 190 . 040 . 042 . 780 . 065Fingermillet0 . 320 . 050 . 031 . 7 6 -5 Pearlmillet0 . 041 . 5 -0 . 355 -O ats0 . 3 -1 . 7 0 . 7 -1 . 1 0 . 1 -0 . 2 0 . 1 -0 . 3 0 . 3 -3 0 . 7 0 . 7 0 . 2 0 . 1 0 . 3 -8 9 1 . 3 -4 . 0 0 . 2 -6 . 3 0 . 3 -0 . 5 0 . 3 -1 . 1 0 . 7 -6 . 1 0 . 910 . 140 . 321 . 3 -3 . 011Genotype0 . 5 5 -0 . 960 . 9 1 -1 . 860 . 0 7 -0 . 130 . 0 5 -0 . 150 . 0 5 -0 . 130 . 0 0 -0 . 061 . 9 -3 . 091Location0 . 7 2 -0 . 961 . 1 7 -1 . 830 . 0 7 -0 . 110 . 0 5 -0 . 140 . 0 8 -0 . 110 . 0 1 -0 . 032 . 1 -3 . 191RiceBrownrice0 . 6 0 . 4 0 . 1 < 0 . 010 . 1 0 . 7 < 0 . 190Polishedrice < 0 . 1 0 . 1 < 0 . 1 < 0 . 1 < 0 . 1 0 . 3 < 0 . 190Milledrice0 . 0 5 -0 . 3 0 . 2 -0 . 5 0 . 1 -0 . 3 -< 0 . 0440 . 3tr0 . 3 0 . 5 0 . 04890 . 060 . 080 . 260 . 020 . 025 -R ye0 . 5 -1 . 8 0 . 7 -1 . 5 0 . 3 -0 . 7 0 . 8 -0 . 9 0 . 6 -3 0 . 8 1 . 3 0 . 4 0 . 9 0 . 689Flour0 . 6 0 . 4 0 . 3 0 . 6 -9 0Meal1 . 0 1 . 4 0 . 3 1 . 190Sorghum0 . 081 . 155Triticale0 . 911 . 030 . 301 . 515Winter0 . 7 -0 . 9593Spring1 . 3 5 -1 . 4593 -W heat1 . 0 0 . 2 0 . 4 1 . 9 -5 0 . 9 -1 . 8 0 . 3 -0 . 7 2 . 5 -3 . 6 4 . 9 -5 . 831 . 0 0 . 4 0 . 9 2 . 5 0 . 0889aTocopherolsincludea -T , 0 -T , y -T , and5 -T , andtocotrienolsincludea -T -3 , 0 -T -3 , y -T -3 , andS -T -3 . ( -) denotedatanotreported ..
  28. Group 2 is compared to Group 1, Group 3 to 6 are compared to group 2.
  29. Unknown Title.
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No external funding was declared for this work.

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The authors declare no conflict of interest.

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How to Cite This Article

Dr. .K.S., nagendra subbaiah, Basavaraj Devaranavadagi. 2013. "Comparative Study of Diallyl-Disulphide and Dipropyl-Disulphide in Experimental Atherosclerosis". Global Journal of Medical Research, Global Journal of Medical Research - K: Interdisciplinary GJMR-K Volume 13 (GJMR Volume 13 Issue K2).

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords
acroleinatherosclerosisDiallyl disulphidedipropyl disulphidelipid profile
Classification
GJMR-K Classification FOR Code: 250302p
  • Submission ReceivedDecember 15, 2012
  • Peer Review Double Blind
    Handling Editor
  • Accepted January 3, 2013
  • Published January 15, 2013
Version of record

v1.2

Issue date
May 2, 2013

Language
English
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Comparative Study of Diallyl-Disulphide and Dipropyl-Disulphide in Experimental Atherosclerosis

Dr. .K.S.
Dr. .K.S. Rajiv Gandhi University of Health Sciences
nagendra subbaiah
nagendra subbaiah
Basavaraj Devaranavadagi
Basavaraj Devaranavadagi
  • Submission ReceivedDecember 15, 2012
  • Peer Review Double Blind
    Handling Editor
  • Accepted January 3, 2013
  • Published January 15, 2013