Comparative Study of Intralesional Dexamethasone, Hyaluronidase and Oral Pentoxifylline in Patients with Oral Submucous Fibrosis

Ibrahim M

Comparative Study of Intralesional Dexamethasone, Hyaluronidase and Oral Pentoxifylline in Patients with Oral Submucous Fibrosis

Ibrahim M * §

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§ Sri Sai College of Dental Surgery, Kothrepally, Vika...

Comparative Study of Intralesional Dexamethasone, Hyaluronidase and Oral Pentoxifylline in Patients with Oral Submucous Fibrosis

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Abstract

Back ground : Oral submucous fibrosis (OSF) is characterized by excessive production of collagen leading to inelasticity of the oral mucosa and atrophic changes of the epithelium. Aim : Aim of the study is to clinically evaluate the efficacy of oral Pentoxifylline 400 mg tablets in comparison to intralesional injections of Dexamethasone (4mg/ml) and Hyaluronidase 1500 IU and 0.5 ml of Lignocaine 2% in the management of OSF patients. Methodology : The study population consisted of 40 male patients with OSF. Patients were divided into two groups. 20 patients are in pentoxifylline group and 20 patients in Dexamethasone group. Pentoxifylline Group received oral Pentoxifylline 400 mg tablets twice daily for first 4 weeks and thrice daily for next 8 weeks. Dexamethasone Group received biweekly intralesional injections of Dexamethasone (4mg/ml), Hyaluronidase 1500 IU and 0.5 ml of Lignocaine 2% for a period of 12 weeks. Parameters taken in the study were burning sensation, mouth opening, tongue protrusion and cheek flexibility.

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Ibrahim M, Ibrahim M. 1970. "Comparative Study of Intralesional Dexamethasone, Hyaluronidase and Oral Pentoxifylline in Patients with Oral Submucous Fibrosis". Global Journal of Medical Research, Global Journal of Medical Research - L: Nutrition GJMR-L Volume 12 (GJMR Volume 12 Issue L7).

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GJMR Volume 12 Issue L7

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

burning sensation cheek flexibili Dexamethasone Hyaluronidase Lignocaine mouth opening Oral submucous fibrosis pentoxifylline tongue protrusion

Classification

GJMR-L Classification NLMC Code: WB 350

WU 158

WU 113

WU 101.5

Submission ReceivedJune 12, 2012
Peer Review Double Blind
Handling Editor
Accepted July 10, 2012
Published July 25, 2012

Version of record

v1.2

Language

English

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Article Matrices

Total Score: 151

Country: India

Subject: Global Journal of Medical Research

Authors: Dr. Anjum Aara, Satishkumar GP, C Vani, Venkat Reddy M, Sreekanth K, Ibrahim M (PhD/Dr. count: 1)

View Count (all-time): 179

Total Views (Real + Logic): 7375

Total Downloads (simulated): 450

Publish Date: 2012 07, Wed

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Total Views: 7.4K

Total Downloads: 450

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