Copper Deficiency: An Overlooked Cause of Anemia and Leucopenia

Avneek Singh Sandhu; James Kim; Sivjot Binepal; Alejandro Calvo

Copper Deficiency: An Overlooked Cause of Anemia and Leucopenia

Avneek Singh Sandhu *

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James Kim

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Sivjot Binepal

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Alejandro Calvo

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Copper Deficiency: An Overlooked Cause of Anemia and Leucopenia

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Abstract

Introduction-Copper deficiency (hypocupremia) is an acknowledged but often overlooked cause of anemia and leukopenia (1-4). It is recognized as a frequent cause of hypochromic microcytic anemia, leukopenia, and neuropathy. Copper deficiency anemia has been reported after gastric resection (e.g., Roux-en-Y) (1, 5, 6), excessive zinc consumption (1, 6-9), and in patients with short bowel syndrome receiving total parenteral or enteral nutrition lacking adequate copper supplementation (1, 2). We report a case of vitamin B12, and iron refractory severe anemia and leucopenia with history of Roux-en-Y surgery. Myelodysplastic syndrome was suspected. Bone marrow biopsy was consistent with copper deficiency and serum copper levels were undetectable. The patient experienced complete hematological recovery after copper replacement therapy.

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17 Cites in Article

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

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Not applicable for this article.

How to Cite This Article

Avneek Singh Sandhu, James Kim, Sivjot Binepal, Alejandro Calvo. 2020. "Copper Deficiency: An Overlooked Cause of Anemia and Leucopenia". Global Journal of Medical Research - F: Diseases GJMR-F Volume 20 (GJMR Volume 20 Issue F5).

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GJMR Volume 20 Issue F5

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

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Classification

GJMR-F Classification NLMC Code: WH 155

Submission ReceivedDecember 12, 2019
Peer Review Double Blind
Handling Editor
Accepted December 31, 2019
Published January 15, 2020

Version of record

v1.2

Issue date

May 9, 2020

Language

English

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