Cornea in Wilson Disease: Kayser Fleischer Ring and Beyond

Cornea in Wilson Disease: Kayser Fleischer Ring and Beyond

Mittanamalli.S.Sridhar

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α Krishna Institute of Medical Sciences

Cornea in Wilson Disease: Kayser Fleischer Ring and Beyond

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Abstract

The identification of Kayser-Fleischer (KF) ring remains the most important clinical sign for the diagnosis of Wilson disease (WD). Slit lamp biomicroscope (SL) examination by a skilled observer is still the preferred method of evaluating KF ring. Anterior segment optical coherence tomography (AS-OCT) is an alternative method of evaluating KF ring in WD. Hyper-reflective layer in the corneal periphery at the level of Descemet membrane (DM) is the characteristic appearance of KF ring on AS-OCT. In a suspected case of WD, features of KF ring on AS-OCT may alert the clinician to do a careful SL examination to look for early KF ring. AS-OCT has been found useful in measuring the length of KF ring with ease even in patients with severe rigidity and children. AS-OCT can measure the length of KF ring better compared to SL in patients with limbal pathology. Early detection of increased corneal copper even before KF rings appear is a potential area for future research.

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No external funding was declared for this work.

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The authors declare no conflict of interest.

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How to Cite This Article

Mittanamalli.S.Sridhar. 2017. \u201cCornea in Wilson Disease: Kayser Fleischer Ring and Beyond\u201d. Global Journal of Medical Research - F: Diseases GJMR-F Volume 17 (GJMR Volume 17 Issue F2): .

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GJMR Volume 17 Issue F2
Pg. 29- 37

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-F Classification: NLMC Code: WW 220

Submission ReceivedDecember 9, 2016
Peer Review Double Blind
Handling Editor
Accepted January 5, 2017
Published January 15, 2017

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August 28, 2017

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Total Score: 101

Country: India

Subject: Global Journal of Medical Research - F: Diseases

Authors: Mittanamalli.S.Sridhar (PhD/Dr. count: 0)

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