Design and Evaluation of a 3-Component Composite Excipient aoMicrocrystarcellaca as a Filler-Binder for Direct Compression Tabletting and its Utilisation in the Formulation of Paracetamol And Ascor

biodun shittu

Design and Evaluation of a 3-Component Composite Excipient aoMicrocrystarcellaca as a Filler-Binder for Direct Compression Tabletting and its Utilisation in the Formulation of Paracetamol And Ascor

biodun shittu * §

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§ University of Jos, Jos, Plataeu State. Nigeria.

Design and Evaluation of a 3-Component Composite Excipient aoMicrocrystarcellaca as a Filler-Binder for Direct Compression Tabletting and its Utilisation in the Formulation of Paracetamol And Ascor

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Abstract

A research was conducted to design and evaluate a highly functional 3-component composite fillerbinder for direct compression. Tapioca starch (NTS) was modified physically at molecular level by annealing and enzyme hydrolyzed to obtain microcrystalline tapioca starch (MCTS) which was coprocessed with LMH and microcrystalline cellulose (MCC) to yield Microcrystarcellac (MSCL). NTS was extracted from cassava tuber ( Mannihot esculenta crantz ) using a standard method. The powder suspensions were prepared in concentration of 40 %w/w in five separate conical flasks. The starch granules were annealed for 1 h and subsequently hydrolyzed with α-amylase at 58o and pH 7 for 1, 2, 3, 4, and 5 h in a water bath. The reaction was terminated and neutralized with 0.1 N HCL and 0.1 N NaOH respectively. The MCTS was washed, recovered by sedimentation and air dried at room temperature for 72 h.

References

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

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Not applicable for this article.

How to Cite This Article

biodun shittu. 1970. "Design and Evaluation of a 3-Component Composite Excipient aoMicrocrystarcellaca as a Filler-Binder for Direct Compression Tabletting and its Utilisation in the Formulation of Paracetamol And Ascor". Global Journal of Medical Research GJMR Volume 12 (GJMR Volume 12 Issue 7).

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GJMR Volume 12 Issue 7

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

Coprocessed Excipient Directly compressible Excipient Highly functional Filler-binder Microcrystalline Tapioca Starch Microcrystarcellac

Classification

GJMR-B Classification NLMC Code: 110405

Submission ReceivedFebruary 4, 2012
Peer Review Double Blind
Handling Editor
Accepted March 5, 2012
Published March 15, 2012

Version of record

v1.2

Issue date

August 19, 2012

Language

English

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Article Matrices

Total Score: 153

Country: Nigeria

Subject: Global Journal of Medical Research

Authors: Dr. Shittu, A.O., Oyi, A.R., Isah, A.B., Ibrahim, M.A (PhD/Dr. count: 1)

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Publish Date: 2012 03, Thu

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