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Design and Evaluation of Nanoparticulate Drug Delivery Systems for Imaging and Treatment of Malignant Brain Tumor

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Design and Evaluation of Nanoparticulate Drug Delivery Systems for Imaging and Treatment of Malignant Brain Tumor

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Design and Evaluation of Nanoparticulate Drug Delivery Systems for Imaging and Treatment of Malignant Brain Tumor Banner

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Abstract

Malignant brain tumours are one of the most devastating human cancers associated with high mortality and morbidity rates. The median survival of malignant glioma patie-nts ranges between 3 and 16 months and has virtually rema-ined unchanged during the last 3 decades. Difficulties in early detection, local recurrence, and resistance to conventional therapies are the major reasons for failure in malignant brain tumour treatment. The therapy of malignant gliomas is further limited by the inadequate delivery of therapeutic agents to the brain due to the presence of the blood-brain barrier, blood-brain-tumor barrier as well as non-specificity targeting. Nanoparticles (NPs) have drawn increased interest in treating malignant brain tumours due to their potential to act as a vector for brain delivery and to provide tumourspecific detection and treatment. If designed appropriately, NPs may act as a drug vehicle able to target tumor tissues or cells, and protect the drug from inactivation during its transport. The aim of this article was to provide brief overview of nanoparticulate drug delivery systems for imaging and treatment of brain cancer and to evaluate their safety in clinical use. Besides invasive physical methods to bypass or disrupt the BBB and/or BBTB, other methods like pharmacological and physio-logic approach are possible.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Minyahil A. Woldu, Jimma Likisa Lenjissa, Gizaw Dabessa Satessa. 2014. "Design and Evaluation of Nanoparticulate Drug Delivery Systems for Imaging and Treatment of Malignant Brain Tumor". Global Journal of Science Frontier Research - G: Bio-Tech & Genetics GJSFR-G Volume 14 (GJSFR Volume 14 Issue 8 (G1)).

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Journal Specifications

Crossref Journal DOI 10.17406/GJSFR

Print ISSN 0975-5896

e-ISSN 2249-4626

Keywords
Classification
GJSFR-G Classification FOR Code: 320206
Version of record
v1.2

Issue date
March 4, 2014

Language
English
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Design and Evaluation of Nanoparticulate Drug Delivery Systems for Imaging and Treatment of Malignant Brain Tumor

Minyahil Woldu
Minyahil Woldu Ambo University
Jimma Lenjissa
Jimma Lenjissa <p>Ambo University</p>
Gizaw Satessa
Gizaw Satessa <p>Ambo University</p>