Design, Synthesis, Spectral Charecterization of Some New Fully Unsaturated 2-Substituted-4, 6 Dichloro Symmetric Triazine- Based Chalcone Hybrids

1
G.V.Pavan Kumar
G.V.Pavan Kumar
2
G. V. Pavan Kumar
G. V. Pavan Kumar
3
D. Srinivasa Rao
D. Srinivasa Rao
4
B. Pooja
B. Pooja
5
G. Harika
G. Harika
6
Y. Anil Kumar
Y. Anil Kumar
1 Kc Reddy Institute of Pharmaceutical Sciences

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Design, Synthesis, Spectral Charecterization of Some New Fully Unsaturated 2-Substituted-4, 6 Dichloro  Symmetric Triazine- Based Chalcone Hybrids Banner
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Triazines and chalcones are interesting class of heterocyclic compounds with a prominent structural core system present in numerous pharmacologically active compounds. It is proved from the literature that the compounds containing 1,3,5-triazine moiety or chalcone bridge often shows significant biological activity profiles. Based on these observations, it was considered worthwhile to synthesize and characterize some new 1,3,5-triazine-chalcone hybrid molecules in the present investigation. As a part of our research program aimed at search for new hybrid pharmacophores as potential cytotoxic agents, we are interested to have α,β-unsaturated ketone linker to the 1,3,5-triazine basic nucleus to give a series of 1,3,5-triazinechalcone hybrid molecules. Therefore, in the present study an attempt has been made to synthesize and characterize various analogs of fully unsaturated 2-substituted-4,6 dichloro-1,3,5 triazine based chalcone hybrids.

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No external funding was declared for this work.

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The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

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Not applicable for this article.

G.V.Pavan Kumar. 2016. \u201cDesign, Synthesis, Spectral Charecterization of Some New Fully Unsaturated 2-Substituted-4, 6 Dichloro Symmetric Triazine- Based Chalcone Hybrids\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 16 (GJMR Volume 16 Issue B1): .

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Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-B Classification: NLMC Code: QV 4
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May 31, 2016

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English

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Triazines and chalcones are interesting class of heterocyclic compounds with a prominent structural core system present in numerous pharmacologically active compounds. It is proved from the literature that the compounds containing 1,3,5-triazine moiety or chalcone bridge often shows significant biological activity profiles. Based on these observations, it was considered worthwhile to synthesize and characterize some new 1,3,5-triazine-chalcone hybrid molecules in the present investigation. As a part of our research program aimed at search for new hybrid pharmacophores as potential cytotoxic agents, we are interested to have α,β-unsaturated ketone linker to the 1,3,5-triazine basic nucleus to give a series of 1,3,5-triazinechalcone hybrid molecules. Therefore, in the present study an attempt has been made to synthesize and characterize various analogs of fully unsaturated 2-substituted-4,6 dichloro-1,3,5 triazine based chalcone hybrids.

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Design, Synthesis, Spectral Charecterization of Some New Fully Unsaturated 2-Substituted-4, 6 Dichloro Symmetric Triazine- Based Chalcone Hybrids

G. V. Pavan Kumar
G. V. Pavan Kumar
D. Srinivasa Rao
D. Srinivasa Rao
B. Pooja
B. Pooja
G. Harika
G. Harika
Y. Anil Kumar
Y. Anil Kumar

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