Neural Networks and Rules-based Systems used to Find Rational and Scientific Correlations between being Here and Now with Afterlife Conditions
Neural Networks and Rules-based Systems used to Find Rational and
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We developed a unique analytical technique for the evaluation of Entecavir monohydrate (ETV) in its pharmaceutical dosage form using derivative spectroscopy assisted FTIR. This approach requires the formation of solid pellets of Entecavir using potassium bromide (KBr) with the aid of geometrical mixing. The spectra were calculated by direct measurement technique using reduced path length in the absorbance mode, and the equipment was configured to secure it at 8cm -1 resolution. We scanned the spectra between the ranges of 4000 to 400 cm -1 . FTIR spectra drug exhibited overlapped functional group peaks with baseline correction at 1631 cm -1 corresponding to C=O stretching. From these FTIR spectra, we detected intense, clear, and proportional second derivative peaks between 1639.38 and 1620.09 cm -1 . These peaks, in the range of concentration 12.5-200 μg/mg, obeyed Beer-Lambert’s law. Therefore, we elected C=O stretching for the quantitative evaluation of Entecavir employing second-order derivative spectroscopy.
Ashraf A Khanam. 2020. \u201cDevelopment and Validation of Derivative FTIR Spectroscopy for Estimation of Entecavir Monohydrate in its Pure and Pharmaceutical Dosage Forms\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 20 (GJMR Volume 20 Issue B5): .
Crossref Journal DOI 10.17406/gjmra
Print ISSN 0975-5888
e-ISSN 2249-4618
The methods for personal identification and authentication are no exception.
Total Score: 103
Country: India
Subject: Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine
Authors: Ashraf A Khanam, Y Padmavathi, Raghavendra Babu (PhD/Dr. count: 0)
View Count (all-time): 129
Total Views (Real + Logic): 2350
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Publish Date: 2020 07, Mon
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We developed a unique analytical technique for the evaluation of Entecavir monohydrate (ETV) in its pharmaceutical dosage form using derivative spectroscopy assisted FTIR. This approach requires the formation of solid pellets of Entecavir using potassium bromide (KBr) with the aid of geometrical mixing. The spectra were calculated by direct measurement technique using reduced path length in the absorbance mode, and the equipment was configured to secure it at 8cm -1 resolution. We scanned the spectra between the ranges of 4000 to 400 cm -1 . FTIR spectra drug exhibited overlapped functional group peaks with baseline correction at 1631 cm -1 corresponding to C=O stretching. From these FTIR spectra, we detected intense, clear, and proportional second derivative peaks between 1639.38 and 1620.09 cm -1 . These peaks, in the range of concentration 12.5-200 μg/mg, obeyed Beer-Lambert’s law. Therefore, we elected C=O stretching for the quantitative evaluation of Entecavir employing second-order derivative spectroscopy.
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