Development of Elastic Nanovesicles for Enhanced Transdermal Delivery of Nebivolol Hydrochloride

Development of Elastic Nanovesicles for Enhanced Transdermal Delivery of Nebivolol Hydrochloride

Aparanjitha.R

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Sunitha Reddy.M

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Sarangapani.M

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α Kakatiya University

Development of Elastic Nanovesicles for Enhanced Transdermal Delivery of Nebivolol Hydrochloride

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Abstract

The present investigation is to prepare and evaluate transfersomal Nebivolol hydrochloride transdermal patches. Rotary evaporation process was used to prepare the nanocarriers. Soya lecithin when used in conjunction with Labrosol was proven to be an effective edge activator for the manufacture of Nebivolol hydrochloride nanocarriers. Several characteristics of the produced nanocarriers were measured, including size, entrapment efficiency, Zeta potential, and photodynamic interference. A design expert programme called DOE (central composite design) was used to optimise the formulations that were chosen. The improved formulation (40% w/v Labrosol and 68% w/v soya lecithin) exhibited particle sizes of 1434.5nm, Zeta value of -39.8, and a percent Entrapment effectiveness of 96 percent, among other characteristics.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

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How to Cite This Article

Aparanjitha.R. 2026. \u201cDevelopment of Elastic Nanovesicles for Enhanced Transdermal Delivery of Nebivolol Hydrochloride\u201d. Unknown Journal GJMR-I Volume 22 (GJMR Volume 22 Issue I3): .

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GJMR Volume 22 Issue I3
Pg. 11- 24

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GJMR-I Classification: NLMC Code: QV 38

Submission ReceivedOctober 15, 2022
Peer Review Double Blind
Handling Editor
Accepted October 24, 2022
Published December 23, 2022

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January 5, 2023

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