Development of Elastic Nanovesicles for Enhanced Transdermal Delivery of Nebivolol Hydrochloride

1
Aparanjitha.R
Aparanjitha.R
2
Sunitha Reddy.M
Sunitha Reddy.M
3
Sarangapani.M
Sarangapani.M
1 University College of Pharmaceutical Sciences

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The objective of our study was to evaluate, in a population of Togolese People Living With HIV(PLWHIV), the agreement between three scores derived from the general population namely the Framingham score, the Systematic Coronary Risk Evaluation (SCORE), the evaluation of the cardiovascular risk (CVR) according to the World Health Organization.
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The present investigation is to prepare and evaluate transfersomal Nebivolol hydrochloride transdermal patches. Rotary evaporation process was used to prepare the nanocarriers. Soya lecithin when used in conjunction with Labrosol was proven to be an effective edge activator for the manufacture of Nebivolol hydrochloride nanocarriers. Several characteristics of the produced nanocarriers were measured, including size, entrapment efficiency, Zeta potential, and photodynamic interference. A design expert programme called DOE (central composite design) was used to optimise the formulations that were chosen. The improved formulation (40% w/v Labrosol and 68% w/v soya lecithin) exhibited particle sizes of 1434.5nm, Zeta value of -39.8, and a percent Entrapment effectiveness of 96 percent, among other characteristics.

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No external funding was declared for this work.

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The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

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Aparanjitha.R. 2026. \u201cDevelopment of Elastic Nanovesicles for Enhanced Transdermal Delivery of Nebivolol Hydrochloride\u201d. Unknown Journal GJMR-I Volume 22 (GJMR Volume 22 Issue I3): .

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Flexible, detailed research on elastic nanovesicles for drug delivery systems.
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January 5, 2023

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The present investigation is to prepare and evaluate transfersomal Nebivolol hydrochloride transdermal patches. Rotary evaporation process was used to prepare the nanocarriers. Soya lecithin when used in conjunction with Labrosol was proven to be an effective edge activator for the manufacture of Nebivolol hydrochloride nanocarriers. Several characteristics of the produced nanocarriers were measured, including size, entrapment efficiency, Zeta potential, and photodynamic interference. A design expert programme called DOE (central composite design) was used to optimise the formulations that were chosen. The improved formulation (40% w/v Labrosol and 68% w/v soya lecithin) exhibited particle sizes of 1434.5nm, Zeta value of -39.8, and a percent Entrapment effectiveness of 96 percent, among other characteristics.

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Development of Elastic Nanovesicles for Enhanced Transdermal Delivery of Nebivolol Hydrochloride

Aparanjitha.R
Aparanjitha.R University College of Pharmaceutical Sciences
Sunitha Reddy.M
Sunitha Reddy.M
Sarangapani.M
Sarangapani.M

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