Development Of Formulation and Technology of Combined Generic Powder for Oral Solution in Sachets Based on the Quality by Design Approach

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Dr. Panysheva
Dr. Panysheva
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Oksana Panysheva
Oksana Panysheva

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GJMR Volume 22 Issue B2

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Using quality by design approaches (dispersion analysis and random balance method), the formulation and technology of powder for oral solution in sachetswere developed. It includes paracetamol, ascorbic acid, phenylephrine hydrochloride, and pheniramine maleate. The influence of 27 excipients from 5 functional groups on 11 quality attributes was established by the dispersion analysis. The preferred excipients were selected using the utility function. The quantities of preferable excipients (7 quantitative factors at three levels) were researched by the random balance method. Their influence on 11 pharmaco-technological parameters of the powder and the physical properties of the solution studied. The optimal composition of the powder for the oral solution established.9 sequences of introducing components were analyzed by dispersion analysis. The optimal technology of the powderfor oral solution in sachets byroll compaction is established.

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

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Dr. Panysheva. 2026. \u201cDevelopment Of Formulation and Technology of Combined Generic Powder for Oral Solution in Sachets Based on the Quality by Design Approach\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 22 (GJMR Volume 22 Issue B2): .

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Enhanced stability in therapeutic drug delivery for oral solutions.
Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-B Classification: DDC Code: 615.783 LCC Code: RM666.A19
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v1.2

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July 9, 2022

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English

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Using quality by design approaches (dispersion analysis and random balance method), the formulation and technology of powder for oral solution in sachetswere developed. It includes paracetamol, ascorbic acid, phenylephrine hydrochloride, and pheniramine maleate. The influence of 27 excipients from 5 functional groups on 11 quality attributes was established by the dispersion analysis. The preferred excipients were selected using the utility function. The quantities of preferable excipients (7 quantitative factors at three levels) were researched by the random balance method. Their influence on 11 pharmaco-technological parameters of the powder and the physical properties of the solution studied. The optimal composition of the powder for the oral solution established.9 sequences of introducing components were analyzed by dispersion analysis. The optimal technology of the powderfor oral solution in sachets byroll compaction is established.

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Development Of Formulation and Technology of Combined Generic Powder for Oral Solution in Sachets Based on the Quality by Design Approach

Dr. Panysheva
Dr. Panysheva
Oksana Panysheva
Oksana Panysheva

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