Early Diagnosis of Neuron Mitochondrial Dysfunction May Reverse Global Metabolic and Neurodegenerative Disease

Early Diagnosis of Neuron Mitochondrial Dysfunction May Reverse Global Metabolic and Neurodegenerative Disease

Ian James Martins

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Early Diagnosis of Neuron Mitochondrial Dysfunction May Reverse Global Metabolic and Neurodegenerative Disease

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D Eisenberg,J Burgess (2015). Nutrition Education in an Era of Global Obesity and Diabetes: Thinking Outside the Box.
Ian Martins (2016). Heat Shock Gene Sirtuin 1 Regulates Post-Prandial Lipid Metabolism with Relevance to Nutrition and Appetite Regulation in Diabetes.
I Martins,R Creegan (2014). Links between Insulin Resistance, Lipoprotein Metabolism and Amyloidosis in Alzheimer's Disease.
G Ricci,L Volpi,L Pasquali,L Petrozzi,G Siciliano (2009). Astrocyte-neuron interactions in neurological disorders.
Antonia Vernadakis (1996). GLIA-NEURON INTERCOMMUNICATIONS AND SYNAPTIC PLASTICITY.
Mark Mattson,Tim Magnus (2006). Ageing and neuronal vulnerability.
Ian Martins (2016). The Role of Clinical Proteomics, Lipidomics, and Genomics in the Diagnosis of Alzheimer’s Disease.
Rachel Lane,Diana Shineman,John Steele,Linda Lee,Howard Fillit (2012). Beyond Amyloid.
I Martins (2016). Anti-Aging Genes Improve Appetite Regulation and Reverse Cell Senescence and Apoptosis in Global Populations.
I Martins (2015). Unhealthy Nutrigenomic Diets Accelerate NAFLD and Adiposity in Global communities.
Ian Martins (2016). Heat Shock Gene Sirtuin 1 Regulates Post-Prandial Lipid Metabolism with Relevance to Nutrition and Appetite Regulation in Diabetes.
E Gulbins,S Dreschers,J Bock (2003). Role of mitochondria in apoptosis.
H Lee,Y Wei (2012). Mitochondria and aging.
Ludmila Voloboueva,Sang Suh,Raymond Swanson,Rona Giffard (2007). Inhibition of mitochondrial function in astrocytes: implications for neuroprotection.
Christopher Koczor,Richard White,Peter Zhao,Linjue Zhu,Earl Fields,William Lewis (2012). p53 and Mitochondrial DNA.
J-H Park,J Zhuang,J Li,P Hwang (2016). p53 as guardian of the mitochondrial genome.
A Safdar,J Little,A Stokl,B Hettinga,M Akhtar (2011). Exercise increases mitochondrial PGC-1alpha content and promotes nuclearmitochondrial cross-talk to coordinate mitochondrial biogenesis.
Nirmalya Sen,Yatendra Satija,Sanjeev Das (2011). PGC-1α, a Key Modulator of p53, Promotes Cell Survival upon Metabolic Stress.
Katia Aquilano,Sara Baldelli,Beatrice Pagliei,Stefano Cannata,Giuseppe Rotilio,Maria Ciriolo (2013). p53 Orchestrates the PGC-1α-Mediated Antioxidant Response Upon Mild Redox and Metabolic Imbalance.
Adi Neufeld-Cohen,Maria Robles,Rona Aviram,Gal Manella,Yaarit Adamovich,Benjamin Ladeuix,Dana Nir,Liat Rousso-Noori,Yael Kuperman,Marina Golik,Matthias Mann,Gad Asher (2016). Circadian control of oscillations in mitochondrial rate-limiting enzymes and nutrient utilization by PERIOD proteins.
Z Sheng,Q Cai (2012). Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration.
Zu-Hang Sheng (2014). Mitochondrial trafficking and anchoring in neurons: New insight and implications.
D Ben-Shachar,D Laifenfeld (2004). Mitochondria, synaptic plasticity, and schizophrenia.
Jacqueline Oliva‐ramírez,María Moreno‐altamirano,Benjamín Pineda‐olvera,Patricia Cauich‐sánchez,F Sánchez‐garcía (2014). Crosstalk between circadian rhythmicity, mitochondrial dynamics and macrophage bactericidal activity.
Sonja Langmesser,Urs Albrecht (2006). Life time—circadian clocks, mitochondria and metabolism.
Fang Hu,Feng Liu (2011). Mitochondrial stress: A bridge between mitochondrial dysfunction and metabolic diseases?.
Vyara Todorova,Arjan Blokland (2016). Mitochondria and Synaptic Plasticity in the Mature and Aging Nervous System.
L Aguilar-Arnal,P Sassone-Corsi (2015). Chromatin landscape and circadian dynamics: Spatial and temporal organization of clock transcription.
M Hirschey,T Shimazu,J Huang,E Verdin (2009). Acetylation of mitochondrial proteins.
B Tang (2016). Sirt1 and the Mitochondria.
Rey,A (2013). Protein acetylation links the circadian clock to mitochondrial function.
K Anderson,M Hirschey (2012). Mitochondrial protein acetylation regulates metabolism.
M Sack,T (2012). Mitochondrial metabolism, sirtuins, and aging.
In Kil,Keun Ryu,Se Lee,Jeong Kim,Sei Chu,Ju Kim,Sunjoo Park,Sue Rhee (2015). Circadian Oscillation of Sulfiredoxin in the Mitochondria.
Julia Brenmoehl,Andreas Hoeflich (2013). Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3.
Matthew Hirschey,Tadahiro Shimazu,John Capra,Katherine Pollard,Eric Verdin (2011). SIRT1 and SIRT3 Deacetylate Homologous Substrates: AceCS1,2 and HMGCS1,2.
Terri-Leigh Stephen,Swati Gupta-Agarwal,Josef Kittler (2014). Mitochondrial dynamics in astrocytes.
R Cabezas,R El-Bachá,J González,G Barreto (2012). Mitochondrial functions in astrocytes: Neuroprotective implications from oxidative damage by rotenone.
Kazuhide Hayakawa,Elga Esposito,Xiaohua Wang,Yasukazu Terasaki,Yi Liu,Changhong Xing,Xunming Ji,Eng Lo (2016). Transfer of mitochondria from astrocytes to neurons after stroke.
Hiroshi Funakoshi,Toshikazu Nakamura (2003). Hepatocyte growth factor: from diagnosis to clinical applications.
A Metcalfe,R Dixon,G Radda (1997). Wild-type but not mutant p53 activates the hepatocyte growth factor/scatter factor promoter.
Y Stein,A Jacob,N Goldfinger,R Straussman,V Rotter (2016). Mutant p53 modulates the signal of hepatocyte growth factor (HGF) to endow cancer cells with drug resistance.
S Xia,J (2006). Hepatocyte growth factor increases mitochondrial mass in glioblastoma cells.
S Tyndall,R Walikonis (2007). Signaling by hepatocyte growth factor in neurons is induced by pharmacological stimulation of synaptic activity.
Flavio Maina,Rüdiger Klein (1999). Hepatocyte growth factor, a versatile signal for developing neurons.
Flavio Maina,Mark Hilton,Rosa Andres,Sean Wyatt,Rüdiger Klein,Alun Davies (1998). Multiple Roles for Hepatocyte Growth Factor in Sympathetic Neuron Development.
M Hamanoue,N Takemoto,K Matsumoto,T Nakamura,K Nakajima (1996). Neurotrophic effect of hepatocyte growth factor on central nervous system neurons in vitro.
W Wong,A Cheung,S Yu,O Sha,E Cho (2014). Hepatocyte growth factor promotes long-term survival and axonal regeneration of retinal ganglion cells after optic nerve injury: comparison with CNTF and BDNF.
Takashi Watanabe,Yoichi Sakata,Shigeki Matsubara,Toshiya Yamagishi,Kazuhiro Nagaike,Tomoyuki Kuwata,Mitsuaki Suzuki (2006). Changes in plasma levels of hepatocyte growth factor and its associated factors during pregnancy.
Mary Chau,Jiaping Gao,Qing Yang,Zhidan Wu,Jesper Gromada (2010). Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK–SIRT1–PGC-1α pathway.
Anu Suomalainen (2013). Fibroblast growth factor 21: a novel biomarker for human muscle-manifesting mitochondrial disorders.
R Davis,C Liang,F Edema-Hildebrand,C Riley,M Needham (2013). Fibroblast growth factor 21 is a sensitive biomarker of mitochondrial disease.
I Martins (2016). Diet and Nutrition reverse Type 3 Diabetes and Accelerated Aging linked to Global chronic diseases.
C Attané,C Foussal,Le Gonidec,S Benani,A Daviaud,D (2012). Apelin treatment increases complete Fatty Acid oxidation, mitochondrial oxidative capacity, and biogenesis in muscle of insulin-resistant mice.
Bruce Frier,Deon Williams,David Wright (2009). The effects of apelin treatment on skeletal muscle mitochondrial content.
Sergey Dikalov,Rafal Nazarewicz (2013). Angiotensin II-Induced Production of Mitochondrial Reactive Oxygen Species: Potential Mechanisms and Relevance for Cardiovascular Disease.
I Martins (2015). Nutritional diets accelerate amyloid beta metabolism and prevent the induction of chronic diseases and Alzheimer's disease.
J Herrmann,R Stuart,E Craig,W Neupert (1994). Mitochondrial heat shock protein 70, a molecular chaperone for proteins encoded by mitochondrial DNA.
C Deocaris,S Kaul,R Wadhwa (2006). On the brotherhood of the mitochondrial chaperones mortalin and heat shock protein 60.
I Martins (2016). Type 3 diabetes with links to NAFLD and Other Chronic Diseases in the Western World.
R Koya,H Fujita,S Shimizu,M Ohtsu,M Takimoto (2000). Gelsolin inhibits apoptosis by blocking mitochondrial membrane potential loss and cytochrome c release.
J An,J Kim,S Jang,C Kim,E Kang (2011). Gelsolin negatively regulates the activity of tumor suppressor p53 through their physical interaction in hepatocarcinoma HepG2 cells.
Y Zhou,X Deng,X Ma,N Zang,H Li (2015). Cellular transcriptomics: gelsolin negatively regulates the expression of apoptosis-associated genes and inhibits apoptosis in hepatocarcinoma cells.
Sonita Chada,Peter Hollenbeck (2004). Nerve Growth Factor Signaling Regulates Motility and Docking of Axonal Mitochondria.
Carissa Chu,Emma Levine,Robert Gear,Oliver Bogen,Jon Levine (2011). Mitochondrial dependence of nerve growth factor-induced mechanical hyperalgesia.
J Zhang,W Yan,X Chen (2006). p53 is required for nerve growth factor-mediated differentiation of PC12 cells via regulation of TrkA levels.
V Wong,D Glass,R Arriaga,G Yancopoulos,R Lindsay (1997). Hepatocyte growth factor promotes motor neuron survival and synergizes with ciliary neurotrophic factor.
C Brynczka,B Merrick (2007). Nerve growth factor potentiates p53 DNA binding but inhibits nitric oxide-induced apoptosis in neuronal PC12 cells.
Xiang Zhou,Qian Hao,Peng Liao,Shiwen Luo,Minhong Zhang,Guohui Hu,Hongbing Liu,Yiwei Zhang,Bo Cao,Melody Baddoo,Erik Flemington,Shelya Zeng,Hua Lu (2016). Nerve growth factor receptor negates the tumor suppressor p53 as a feedback regulator.
Andrea Tedeschi,Simone Di Giovanni (2009). The non‐apoptotic role of p53 in neuronal biology: enlightening the dark side of the moon.
Keshavan Bina,Benjamin Rusak (1996). Nerve growth factor phase shifts circadian activity rhythms in Syrian hamsters.
Gastón Pizzio,Ernesto Hainich,Santiago Plano,Martin Ralph,Diego Golombek (2005). Nerve growth factor‐induced circadian phase shifts and MAP kinase activation in the hamster suprachiasmatic nuclei.
M‐u Jang,J‐w Park,H‐s Kho,S‐c Chung,J‐w Chung (2011). Plasma and saliva levels of nerve growth factor and neuropeptides in chronic migraine patients.
Enzo Emanuele,Pierluigi Politi,Marika Bianchi,Piercarlo Minoretti,Marco Bertona,Diego Geroldi (2006). Raised plasma nerve growth factor levels associated with early-stage romantic love.
Ji‐hoon Park,Jie Zhuang,Jie Li,Paul Hwang (2016). p53 as guardian of the mitochondrial genome.
M Sádaba,I Martín-Estal,J Puche,I Castilla-Cortázar (2016). Insulin-like growth factor 1 (IGF-1) therapy: Mitochondrial dysfunction and diseases.
Manisha Sinha,Young Jang,Juhyun Oh,Danika Khong,Elizabeth Wu,Rohan Manohar,Christine Miller,Samuel Regalado,Francesco Loffredo,James Pancoast,Michael Hirshman,Jessica Lebowitz,Jennifer Shadrach,Massimiliano Cerletti,Mi-Jeong Kim,Thomas Serwold,Laurie Goodyear,Bernard Rosner,Richard Lee,Amy Wagers (2014). Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle.
M Yamamoto,G Iguchi,H Fukuoka,K Suda,H Bando (2013). SIRT1 regulates adaptive response of the growth hormone--insulin-like growth factor-I axis under fasting conditions in liver.
Danielle Doll,Stephanie Rellick,Taura Barr,Xuefang Ren,James Simpkins (2015). Rapid mitochondrial dysfunction mediates <scp>TNF</scp>‐alpha‐induced neurotoxicity.
Manu Jain,Stephanie Rivera,Elena Monclus,Lauren Synenki,Aaron Zirk,James Eisenbart,Carol Feghali-Bostwick,Gokhan Mutlu,G Budinger,Navdeep Chandel (2013). Mitochondrial Reactive Oxygen Species Regulate Transforming Growth Factor-β Signaling.
Heidemarie Gast,Sonja Gordic,Saskia Petrzilka,Martin Lopez,Andreas Müller,Anton Gietl,Christoph Hock,Thomas Birchler,Adriano Fontana (2012). Transforming growth factor‐beta inhibits the expression of clock genes.
M Lopez,D Meier,A Müller,P Franken,J Fujita (2014). Tumor necrosis factor and transforming growth factor β regulate clock genes by controlling the expression of the cold inducible RNA-binding protein (CIRBP).
M Barnea,N Chapnik,Y Genzer,O Froy (2015). The circadian clock machinery controls adiponectin expression.
P Gómez-Abellán,C Gómez-Santos,J Madrid,F Milagro,J Campion (2010). Circadian expression of adiponectin and its receptors in human adipose tissue.
C Nilsson,F Stahlberg,C Thomsen,O Henriksen,M Herning,C Owman (1992). Circadian variation in human cerebrospinal fluid production measured by magnetic resonance imaging.
Lu Gan,Jun Yan,Zhenjiang Liu,Min Feng,Chao Sun (2015). Adiponectin Prevents Reduction of Lipid‐Induced Mitochondrial Biogenesis via AMPK/ACC2 Pathway in Chicken Adipocyte.
Liping Qiao,Brice Kinney,Hyung Yoo,Bonggi Lee,Jerome Schaack,Jianhua Shao (2012). Adiponectin Increases Skeletal Muscle Mitochondrial Biogenesis by Suppressing Mitogen-Activated Protein Kinase Phosphatase-1.
G Roué,N Bitton,V Yuste,T Montange,M Rubio (2003). Mitochondrial dysfunction in CD47mediated caspase-independent cell death: ROS production in the absence of cytochrome c and AIF release.
E Frazier,J Isenberg,S Shiva,L Zhao,P Schlesinger (2011). Age-dependent regulation of skeletal muscle mitochondria by the thrombospondin-1 receptor CD47.
G Grossfeld,D Ginsberg,J Stein,B Bochner,D Esrig,P Nichols,C Taylor,R Cote,S Groshen,M Dunn,D Skinner (1997). Thrombospondin-1 Expression in Bladder Cancer: Association With p53 Alterations, Tumor Angiogenesis, and Tumor Progression.
A Alvarez,J Axelrod,R Whitaker,P Isner,R Bentley (2001). Thrombospondin-1 expression in epithelial ovarian carcinoma: association with p53 status, tumor angiogenesis, and survival in platinum-treated patients.
Sukhbir Kaur,David Soto-Pantoja,Erica Stein,Chengyu Liu,Abdel Elkahloun,Michael Pendrak,Alina Nicolae,Satya Singh,Zuqin Nie,David Levens,Jeffrey Isenberg,David Roberts (1673). Thrombospondin-1 Signaling through CD47 Inhibits Self-renewal by Regulating c-Myc and Other Stem Cell Transcription Factors.
Kwan-Hyuck Baek,Dongha Bhang,Alexander Zaslavsky,Liang-Chuan Wang,Anil Vachani,Carla Kim,Steven Albelda,Gerard Evan,Sandra Ryeom (2013). Thrombospondin-1 mediates oncogenic Ras–induced senescence in premalignant lung tumors.
R Hage-Sleiman,M Esmerian,H Kobeissy,G Dbaibo (2013). p53 and Ceramide as Collaborators in the Stress Response.
G Dbaibo,M Pushkareva,R Rachid,N Alter,M Smyth,L Obeid,Y Hannun (1998). p53-dependent ceramide response to genotoxic stress..
Zhixin Shen,Chong Liu,Pingping Liu,Jiamin Zhao,Wanpeng Xu (2014). Sphingosine 1-phosphate (S1P) promotes mitochondrial biogenesis in Hep G2 cells by activating Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α).
E Sikora,A Bielak-Zmijewska,G Mosieniak (2014). Cellular senescence in ageing, age-related disease and longevity.
James Russell,David Golovoy,Andrea Vincent,Pia Mahendru,James Olzmann,Alice Mentzer,Eva Feldman (2002). High glucose‐induced oxidative stress and mitochondrial dysfunction in neurons.
Larysa Yuzefovych,Glenn Wilson,Lyudmila Rachek (2010). Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress.
Galina Mironova,Elena Gritsenko,Odile Gateau-Roesch,Christiane Levrat,Alexey Agafonov,Konstantin Belosludtsev,Annie Prigent,Danina Muntean,Madeleine Dubois,Michel Ovize (2004). Formation of Palmitic Acid/Ca2+ Complexes in the Mitochondrial Membrane: A Possible Role in the Cyclosporin-Insensitive Permeability Transition.
B Kwon,H Querfurth (2014). Opposite effects of saturated and unsaturated free fatty acids on intracellular signaling and metabolism in neuronal cells.
Daniele Penzo,Chiara Tagliapietra,Raffaele Colonna,Valeria Petronilli,Paolo Bernardi (2002). Effects of fatty acids on mitochondria: implications for cell death.
Yung-Hsuan Hsiao,Null- Lin,Hsiang Liao,Yue-Hua Chen,Shyh-Hsiang Lin (2014). Palmitic Acid-Induced Neuron Cell Cycle G2/M Arrest and Endoplasmic Reticular Stress through Protein Palmitoylation in SH-SY5Y Human Neuroblastoma Cells.
I Martins (2013). Increased Risk for Obesity and Diabetes with Neurodegeneration in Developing Countries.
Chunzi Liang,Benjamin Curry,Patricia Brown,Michael Zemel (2014). Leucine Modulates Mitochondrial Biogenesis and SIRT1-AMPK Signaling in C2C12 Myotubes.
Xiaocun Sun,Michael Zemel (2009). Leucine modulation of mitochondrial mass and oxygen consumption in skeletal muscle cells and adipocytes.
Jian Zhang,Sunitha Meruvu,Yudhishtar Bedi,Jason Chau,Andrix Arguelles,Robert Rucker,Mahua Choudhury (2015). Pyrroloquinoline quinone increases the expression and activity of Sirt1 and -3 genes in HepG2 cells.
Kazuhiko Higashida,Sang Kim,Su Jung,Meiko Asaka,John Holloszy,Dong-Ho Han (2013). Effects of Resveratrol and SIRT1 on PGC-1α Activity and Mitochondrial Biogenesis: A Reevaluation.
Sangjin Seo,Mak-Soon Lee,Eugene Chang,Yoonjin Shin,Soojung Oh,In-Hwan Kim,Yangha Kim (2015). Rutin Increases Muscle Mitochondrial Biogenesis with AMPK Activation in High-Fat Diet-Induced Obese Rats.
K Su,C Yu,Y Chen,Y Huang,C Chen (2014). Rutin, a flavonoid and principal component of saussurea involucrata, attenuates physical fatigue in a forced swimming mouse model.
I Martins (2015). Overnutrition Determines LPS Regulation of Mycotoxin Induced Neurotoxicity in Neurodegenerative Diseases.

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How to Cite This Article

Ian James Martins. 2016. \u201cEarly Diagnosis of Neuron Mitochondrial Dysfunction May Reverse Global Metabolic and Neurodegenerative Disease\u201d. Global Journal of Medical Research - A: Neurology & Nervous System GJMR-A Volume 16 (GJMR Volume 16 Issue A2): .

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GJMR Volume 16 Issue A2
Pg. 33- 40

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Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-A Classification: NLMC Code: WL 358.5

Submission ReceivedDecember 9, 2015
Peer Review Double Blind
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Accepted January 5, 2016
Published January 15, 2016

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November 6, 2016

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Total Score: 131

Country: Australia

Subject: Global Journal of Medical Research - A: Neurology & Nervous System

Authors: Martins IJ (PhD/Dr. count: 0)

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