1. Eisenberg D.M,Burgess J.D (2015). Nutrition Education in an Era of Global Obesity and Diabetes: Thinking Outside the Box. Acad. Med, 90(7), 854-860.
2. Martins I.J (2016). Appetite Control with Relevance to Mitochondrial Biogenesis and Activation of Post- Prandial Lipid Metabolism in Obesity Linked Diabetes. Ann. Obes. Disord, 1(3), 1-3.
3. Ian Martins,Rhona Creegan (2014). Links between Insulin Resistance, Lipoprotein Metabolism and Amyloidosis in Alzheimer’s Disease. Health, 06(12), 1549-1579.
4. G. Ricci,L. Volpi,L. Pasquali,L. Petrozzi,G. Siciliano (2009). Astrocyte–neuron interactions in neurological disorders. Journal of Biological Physics, 35(4), 317-336.
5. Antonia Vernadakis (1996). GLIA-NEURON INTERCOMMUNICATIONS AND SYNAPTIC PLASTICITY. Progress in Neurobiology, 49(3), 185-214.
6. Mattson M.P,Magnus T (2006). Ageing and neuronal vulnerability. Nat Rev Neurosci, 7(4), 278-294.
7. Ian Martins (2016). The Role of Clinical Proteomics, Lipidomics, and Genomics in the Diagnosis of Alzheimer’s Disease. Proteomes, 4(2), 14.
8. Lane R.F,Shineman D.W,Steele J.W,Lee L.B,Fillit H.M (2012). Beyond amyloid: the future of therapeutics for Alzheimer's disease. Adv Pharmacol, 64, 213-271.
9. Ian Martins (2016). Anti-Aging Genes Improve Appetite Regulation and Reverse Cell Senescence and Apoptosis in Global Populations. Advances in Aging Research, 05(01), 9-26.
10. I. Martins (2015). Unhealthy Nutrigenomic Diets Accelerate NAFLD and Adiposity in Global communities. Journal of Molecular and Genetic Medicine, 09(01), 1-11.
11. Mitochondrial Biogenesis (2016). Presentation: Antiaging genes regulate post-prandial lipid metabolism with relevance to appetite, chronic disease and neurodegeneration. 2nd International Conference and Expo on Lipids: Metabolism Nutrition and Health, 03-05.
12. Erich Gulbins,Stephan Dreschers,Jürgen Bock (2003). Role of Mitochondria in Apoptosis. Experimental Physiology, 88(1), 85-90.
13. Lee H.C,Wei Y.H (2012). Mitochondria and Aging. Adv Exp Med Biol, 942, 311-327.
14. Voloboueva L.A,Suh S.W,Swanson R.A,Giffard R.G (2007). Inhibition of mitochondrial function in astrocytes: implications for neuroprotection. J Neurochem, 102(4), 1383-1394.
15. Koczor C.A,Zhao White R.C,Fields Zhu L (2012). p53 and Mitochondrial DNA, Their Role in Mitochondrial Homeostasis and Toxicity of Antiretrovirals. Am J Pathol, 180(6), 2276-2283.
16. Ji‐hoon Park,Jie Zhuang,Jie Li,Paul Hwang (2016). p53 as guardian of the mitochondrial genome. FEBS Letters, 590(7), 924-934.
17. Safdar A,Little J.P,Stokl A.J,Akhtar Hettinga B.P (2011). Exercise Increases Mitochondrial PGC-1α Content and Promotes Nuclear-Mitochondrial Cross-talk to Coordinate Mitochondrial Biogenesis. J Biol Chem, 286(12), 0605-1061.
18. Sen N,Satija Y.K,Das S (2011). PGC-1α, a Key Modulator of p53, Promotes Cell Survival upon Metabolic Stress. Mol Cell, 44(4), 621-634.
19. Katia Aquilano,Sara Baldelli,Beatrice Pagliei,Stefano Cannata,Giuseppe Rotilio,Maria Ciriolo (2013). p53 Orchestrates the PGC-1α-Mediated Antioxidant Response Upon Mild Redox and Metabolic Imbalance. Antioxidants & Redox Signaling, 18(4), 386-399.
20. Neufeld-Cohen A,Aviram Robles M.S,Adamovich Manella G (2016). Circadian control of oscillations in mitochondrial rate-limiting enzymes and nutrient utilization by PERIOD proteins. Proceedings of the National Academy of Sciences, 113(12), 1673-1682.
21. Zu-Hang Sheng,Qian Cai (2012). Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration. Nature Reviews Neuroscience, 13(2), 77-93.
22. Sheng Z.H (2014). Mitochondrial trafficking and anchoring in neurons: New insight and implications. J Cell Biol, 204(7), 1087-1098.
23. Ben-Shachar D,Laifenfeld D (2004). Mitochondria, Synaptic Plasticity, And Schizophrenia. Int Rev Neurobiol, 59, 273-296.
24. Cauich-Sánchez Pineda- Olvera B,Sánchez-García FJ (2014). Crosstalk between circadian rhythmicity, mitochondrial dynamics and macrophage bactericidal activity Immunology. Immunology, 143(3), 490-497.
25. (2006). Life time-circadian clocks, mitochondria and metabolism. Chronobiol Int, 23(1-2), 151-7.
26. Hu F,Liu F (2011). Mitochondrial stress: A bridge between mitochondrial dysfunction and metabolic diseases?. Cell Signal, 23(10), 1528-1533.
27. Vyara Todorova,Arjan Blokland (2016). Mitochondria and Synaptic Plasticity in the Mature and Aging Nervous System. Current Neuropharmacology, 15(1), 166-173.
28. Aguilar-Arnal L,Sassone-Corsi P (2015). Chromatin landscape and circadian dynamics: Spatial and temporal organization of clock transcription. Proc Natl Acad Sci U S A, 112(22), 6863-6870.
29. Shimazu Hirschey M.D,Huang J.Y,Verdin E (2009). Acetylation of mitochondrial proteins. Methods Enzymol, 457, 137-147.
30. B. Tang (2016). Sirt1 and the Mitochondria. Mol Cells, 39(2), 87-95.
31. Rey,A. (2013). Protein acetylation links the circadian clock to mitochondrial function. Proc Natl Acad Sci U S A, 110(9), 3210-3211.
32. Kristin Anderson,Matthew Hirschey (2012). Mitochondrial protein acetylation regulates metabolism. Essays in Biochemistry, 52, 23-35.
33. M. Sack,T. Finkel (2012). Mitochondrial Metabolism, Sirtuins, and Aging. Cold Spring Harbor Perspectives in Biology, 4(12), a013102-a013102.
34. Kil I.S,Ryu K.W,Lee S.K,Kim J.Y,Chu al (2015). Circadian Oscillation of Sulfiredoxin in the Mitochondria. Mol Cell, 59(4), 651-663.
35. Julia Brenmoehl,Andreas Hoeflich (2013). Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3. Mitochondrion, 13(6), 755-761.
36. Shimazu Hirschey M.D,Capra J.A,Pollard K.S,Verdin E (2011). SIRT1 and SIRT3 Deacetylate Homologous Substrates: AceCS1,2 and HMGCS1,2. Aging, 3(6), 635-642.
37. Gupta-Agarwal Stephen T.L,Kittler J.T (2014). Mitochondrial dynamics in astrocytes. Biochem Soc Trans, 42(5), 1302-1310.
38. Ricardo Cabezas,Ramon El-Bachá,Janneth González,George Barreto (2012). Mitochondrial functions in astrocytes: Neuroprotective implications from oxidative damage by rotenone. Neuroscience Research, 74(2), 80-90.
39. Esposito Hayakawa K,Terasaki Wang X,et Liu Y (2016). Transfer of mitochondria from astrocytes to neurons after stroke. Nature, 535(7613), 551-555.
40. Hiroshi Funakoshi,Toshikazu Nakamura (2003). Hepatocyte growth factor: from diagnosis to clinical applications. Clinica Chimica Acta, 327(1-2), 1-23.
41. A. Metcalfe,R. Dixon,G. Radda (1997). Wild-Type But Not Mutant p53 Activates the Hepatocyte Growth Factor/Scatter Factor Promoter. Nucleic Acids Research, 25(5), 983-986.
42. Y. Stein,A. Jacob,N. Goldfinger,R. Straussman,V. Rotter (2016). Mutant p53 modulates the signal of hepatocyte growth factor (HGF) to endow cancer cells with drug resistance. European Journal of Cancer, 61(Supplement 1), S134.
43. Xia S,Laterra J (2006). Hepatocyte growth factor increases mitochondrial mass in glioblastoma cells. Biochem Biophys Res Commun, 345(4), 1358-1364.
44. Stephanie Tyndall,Randall Walikonis (2007). Signaling by hepatocyte growth factor in neurons is induced by pharmacological stimulation of synaptic activity. Synapse, 61(4), 199-204.
45. Maina F,Klein R (1999). Hepatocyte growth factor, a versatile signal for developing neurons. Nat Neurosci, 2(3), 213-217.
46. Maina F,Andres Hilton M.C,Klein Wyatt S,et al (1998). Multiple Roles for Hepatocyte Growth Factor in Sympathetic Neuron Development. Neuron, 20(5), 835-846.
47. Takemoto Hamanoue M,Nakamura Matsumoto K,Nakajima al (1996). Neurotrophic effect of hepatocyte growth factor on central nervous system neurons in vitro. J Neurosci Res, 43(5), 554-564.
48. Wong W.K,Yu Cheung A.W,Sha O,Cho E.Y (2014). Hepatocyte Growth Factor Promotes Long‐Term Survival and Axonal Regeneration of Retinal Ganglion Cells after Optic Nerve Injury: Comparison with CNTF and BDNF. CNS Neurosci Ther, 20(10), 916-929.
49. Sakata Watanabe T,Yamagishi Matsubara S,Kuwata Nagaike K,et al (2006). Changes in plasma levels of hepatocyte growth factor and its associated factors during pregnancy. J Obstet Gynaecol Res, 32(1), 10-14.
50. Gao Chau M.D,Wu Yang Q,Gromada J (2010). Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK–SIRT1–PGC-1α pathway. Proc Natl Acad Sci U S A, 107(28), 2553-1255.
51. Suomalainen A (2013). Fibroblast growth factor 21: a novel biomarker for human muscle-manifesting mitochondrial disorders. Expert Opin Med Diagn, 7(4), 313-317.
52. Liang Davis R.L,Riley Edema-Hildebrand F,et Needham M (2013). Fibroblast growth factor 21 is a sensitive biomarker of mitochondrial disease. Neurology, 81(21), 1819-1826.
53. I. Martins (2016). Diet and Nutrition reverse Type 3 Diabetes and Accelerated Aging linked to Global chronic diseases. J Diab Res Ther, 2(2), 1-6.
54. Foussal Attané C,Benani Le Gonidec S,et Daviaud D (2012). Apelin Treatment Increases Complete Fatty Acid Oxidation, Mitochondrial Oxidative Capacity, and Biogenesis in Muscle of Insulin-Resistant Mice. Diabetes, 61(2), 310-320.
55. Bruce Frier,Deon Williams,David Wright (2009). The effects of apelin treatment on skeletal muscle mitochondrial content. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 297(6), R1761-R1768.
56. Dikalov S.I,Nazarewicz R.R (2013). Angiotensin II-Induced Production of Mitochondrial Reactive Oxygen Species: Potential Mechanisms and Relevance for Cardiovascular Disease. Antioxid Redox Signal, 19(10), 1085-1094.
57. I. Martins (2015). Nutritional diets accelerate amyloid beta metabolism and prevent the induction of chronic diseases and Alzheimer’s disease. Photon ebooks. UBN: 015-A9451011
58. J. Herrmann,R. Stuart,E. Craig,W. Neupert (1994). Mitochondrial heat shock protein 70, a molecular chaperone for proteins encoded by mitochondrial DNA. The Journal of cell biology, 127(4), 893-902.
59. Custer Deocaris,Sunil Kaul,Renu Wadhwa (2006). On the brotherhood of the mitochondrial chaperones mortalin and heat shock protein 60. Cell Stress & Chaperones, 11(2), 116.
60. I. Martins (2016). Type 3 diabetes with links to NAFLD and Other Chronic Diseases in the Western World. Int J Diab, 1, 1-5.
61. Fujita Koya R.C,Ohtsu Shimizu S,et Takimoto M (2000). Gelsolin Inhibits Apoptosis by Blocking Mitochondrial Membrane Potential Loss and Cytochrome c Release. J Biol Chem, 275(20), 5343-1534.
62. An J.H,Kim J.W,Jang S.M,Kim C.H,et Kang E.J (2011). Gelsolin negatively regulates the activity of tumor suppressor p53 through their physical interaction in hepatocarcinoma HepG2 cells. Biochem Biophys Res Commun, 412(1), 44-49.
63. Y. Zhou,X. Deng,X. Ma,N. Zang,H. Li (2015). Cellular transcriptomics: gelsolin negatively regulates the expression of apoptosis-associated genes and inhibits apoptosis in hepatocarcinoma cells. Int J Clin Exp Pathol, 8(11), 3871-85.
64. Chada S.R,Hollenbeck P.J (2004). Nerve Growth Factor Signaling Regulates Motility and Docking of Axonal Mitochondria. Curr Biol, 14(14), 1272-1276.
65. Levine Chu C,Bogen Gear R.W,Levine J.D (2011). Mitochondrial dependence of nerve growth factor-induced mechanical hyperalgesia. Pain, 152(8), 1832-1837.
66. J. Zhang,W. Yan,X. Chen (2006). p53 is required for nerve growth factor-mediated differentiation of PC12 cells via regulation of TrkA levels. Cell Death & Differentiation, 13(12), 2118-2128.
67. Wong V,Arriaga Glass D.J,Yancopoulos G.D,et Lindsay R.M (1997). Hepatocyte Growth Factor Promotes Motor Neuron Survival and Synergizes with Ciliary Neurotrophic Factor. J Biol Chem, 272(8), 5187-5191.
68. Brynczka C,Merrick B.A (2007). Nerve Growth Factor Potentiates p53 DNA Binding but Inhibits Nitric Oxide-Induced Apoptosis in Neuronal PC12 Cells. Neurochem Res, 32(9), 1573-1585.
69. Hao Zhou X,Luo Liao P,et Zhang M (2016). Nerve growth factor receptor negates the tumor suppressor p53 as a feedback regulator. eLife, 5, 15099.
70. Tedeschi A,Di S (2009). The nonapoptotic role of p53 in neuronal biology: enlightening the dark side of the moon. EMBO Rep, 10(6), 576-83.
71. Keshavan Bina,Benjamin Rusak (1996). Nerve growth factor phase shifts circadian activity rhythms in Syrian hamsters. Neuroscience Letters, 206(2-3), 97-100.
72. Pizzio G.A,Hainich E.C,Plano S.A,Ralph M.R,Golombek D.A (2005). Nerve growth factorinduced circadian phase shifts and MAP kinase activation in the hamster suprachiasmatic nuclei European J Neurosci.
73. Jang M.U,Park J.W,Kho H.S,Chung S.C,Chung J.W (2011). Plasma and saliva levels of nerve growth factor and neuropeptides in chronic migraine patients. Oral Dis, 17(2), 187-193.
74. Politi Emanuele E,Minoretti Bianchi M,et Bertona M (2006). Raised plasma nerve growth factor levels associated with early-stage romantic love. Psychoneuroendocrinology, 31(3), 288-294.
75. Ji‐hoon Park,Jie Zhuang,Jie Li,Paul Hwang (2016). p53 as guardian of the mitochondrial genome. FEBS Letters, 590(7), 924-934.
76. M. Sádaba,I. Martín-Estal,J. Puche,I. Castilla-Cortázar (2016). Insulin-like growth factor 1 (IGF-1) therapy: Mitochondrial dysfunction and diseases. Biochim Biophys Acta, 1862(7), 1267-1278.
77. Sinha M,Oh Jang Y.C,Wu Khong D,et al (2014). Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle. Science, 344(6184), 649-652.
78. Iguchi Yamamoto M,Suda Fukuoka H,et Bando H (2013). SIRT1 regulates adaptive response of the growth hormone--insulin-like growth factor-I axis under fasting conditions in liver. Proc Natl Acad Sci U S A, 110(37), 4948-1495.
79. Doll D.N,Rellick S.L,Ren Barr T.L,Simpkins J.W (2015). Rapid mitochondrial dysfunction mediates TNF ‐alpha‐induced neurotoxicity. J Neurochem, 132(4), 443-451.
80. Jain M.,Rivera S.,Monclus E.A.,Synenki L.,Zirk A. (2013). Mitochondrial reactive oxygen species regulate transforming growth factor-β signaling. J Biol Chem, 288(2), 770-7.
81. Gordic Gast H,Lopez Petrzilka S,et Müller A (2012). Transforming growth factor‐beta inhibits the expression of clock genes. Annals of the New York Academy of Sciences, 1261(1), 79-87.
82. Meier Lopez M,Franken Müller A,et Fujita J (2014). Tumor Necrosis Factor and Transforming Growth Factor β Regulate Clock Genes by Controlling the Expression of the Cold Inducible RNA-binding Protein (CIRBP). J Biol Chem, 289(5), 2736-2744.
83. Barnea M,Chapnik N,Genzer Y,Froy O (2015). The circadian clock machinery controls adiponectin expression. Mol Cell Endocrinol, 399, 284-287.
84. Gómez-Santos Gómez-Abellán P,Madrid J.A,Campion Milagro F.I,et al (2010). Circadian Expression of Adiponectin and Its Receptors in Human Adipose Tissue. Endocrinology, 151(1), 115-122.
85. Ståhlberg Nilsson C,Henriksen Thomsen C,et Herning M (1992). Circadian variation in human cerebrospinal fluid production measured by magnetic resonance imaging. Am J Physiol; 262(1 Pt 2): R
86. Gan L,Yan J,Liu Z,Feng M,Sun C (2015). Adiponectin Prevents Reduction of Lipid‐Induced Mitochondrial Biogenesis via AMPK/ACC2 Pathway in Chicken Adipocyte. J Cell Biochem, 116(6), 1090-1100.
87. Kinney Qiao L,Lee Yoo H.S,et Schaack J (2012). Adiponectin Increases Skeletal Muscle Mitochondrial Biogenesis by Suppressing Mitogen-Activated Protein Kinase Phosphatase-1. Diabetes, 61(6), 1463-1470.
88. Bitton Roué G,Montange Yuste V.J,et Rubio M (2003). Mitochondrial dysfunction in CD47-mediated caspase-independent cell death: ROS production in the absence of cytochrome c and AIF release. Biochimie, 85(8), 741-746.
89. E. Frazier,Shiva Isenberg J.S,Schlesinger Zhao L,et al (2011). Age-dependent regulation of skeletal muscle mitochondria by the thrombospondin-1 receptor CD47. Matrix Biol, 30(2), 154-161.
90. Grossfeld G.D,Ginsberg D.A,Stein J.P,Esrig Bochner B.H,et al (1997). Thrombospondin-1 expression in bladder cancer: association with p53 alterations, tumor angiogenesis, and tumor progression. J Natl Cancer Inst, 89(3), 219-27.
91. Alvarez A.A,Axelrod J.R,Whitaker R.S,Isner P.D,et Bentley R.C (2001). Thrombospondin-1 Expression in Epithelial Ovarian Carcinoma: Association with p53 Status, Tumor Angiogenesis, and Survival in Platinum-Treated Patients. Gynecol Oncol, 82(2), 273-278.
92. Kaur S,Soto-Pantoja D.R,Liu Stein E.V,A. Elkahloun,et al (2013). Thrombospondin-1 Signaling through CD47 Inhibits Self-renewal by Regulating c-Myc and Other Stem Cell Transcription Factors Scientific Reports. Scientific Reports, 3(1), 1-12.
93. Bhang Baek K.H,Zaslavsky A,Vachani Wang L.C,et al (2013). Thrombospondin-1 mediates oncogenic Ras–induced senescence in premalignant lung tumors. J Clin Invest, 123(10), 4375-4389.
94. Hage-Sleiman R,Kobeissy Esmerian M.O,Dbaibo G (2013). p53 and Ceramide as Collaborators in the Stress Response. Int J Mol Sci, 14(3), 4982-5012.
95. Dbaibo G.S,Pushkareva M.Y,Alter Rachid R.A,et Smyth M.J (1998). p53-dependent ceramide response to genotoxic stress. J Clin Invest, 102(2), 329-339.
96. Shen Z,Liu C,Liu P,Zhao W (2014). Sphingosine 1-phosphate (S1P) promotes mitochondrial biogenesis in Hep G2 cells by activating Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α). Cell Stress Chaperones, 19(4), 541-548.
97. Ewa Sikora,Anna Bielak-Zmijewska,Grazyna Mosieniak (2014). Cellular Senescence in Ageing, Age-Related Disease and Longevity. Current Vascular Pharmacology, 12(5), 698-706.
98. Golovoy Russell J.W,Mahendru Vincent A.M,et Olzmann J.A (2002). High glucose‐induced oxidative stress and mitochondrial dysfunction in neurons. FASEB J, 16(13), 1738-1748.
99. Yuzefovych L,Wilson G,Rachek L (2010). Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress. Am J Physiol Endocrinol Metab; 299(6): E, 299(6)
100. Gritsenko Mironova G.D,Levrat Gateau-Roesch O,et Agafonov A (2004). Formation of Palmitic Acid/Ca2+ Complexes in the Mitochondrial Membrane: A Possible Role in the Cyclosporin-Insensitive Permeability Transition. J Bioenerg Biomembr, 36(2), 171-178.
101. B. Kwon,H. Querfurth (2014). Opposite effects of saturated and unsaturated free fatty acids on intracellular signaling and metabolism in neuronal cells. Inflammation and Cell Signaling, 1, e200.
102. Penzo D,Tagliapietra C,Colonna R,Petronilli V,Bernardi P (2002). Effects of fatty acids on mitochondria: implications for cell death. Biochim Biophys Acta, 1555(1-3), 160-165.
103. Hsiao Y.H,Liao Lin C.I,Chen Y.H,Lin S.H (2014). Palmitic Acid-Induced Neuron Cell Cycle G2/M Arrest and Endoplasmic Reticular Stress through Protein Palmitoylation in SH-SY5Y Human Neuroblastoma Cells. Int J Mol Sci, 15(11), 0876-2089.
104. I. Martins (2013). Increased Risk for Obesity and Diabetes with Neurodegeneration in Developing Countries. Journal of Molecular and Genetic Medicine, s1(01), 1-12.
105. Chunzi Liang,Benjamin Curry,Patricia Brown,Michael Zemel (2014). Leucine Modulates Mitochondrial Biogenesis and SIRT1-AMPK Signaling in C2C12 Myotubes. Journal of Nutrition and Metabolism, 2014, 1-11.
106. Xiaocun Sun,Michael Zemel (2009). Leucine modulation of mitochondrial mass and oxygen consumption in skeletal muscle cells and adipocytes. Nutrition & Metabolism, 6(1), 26.
107. Meruvu Zhang J,Chau Bedi Y.S,et Arguelles A (2015). Pyrroloquinoline quinone increases the expression and activity of Sirt1 and -3 genes in HepG2 cells. Nutr Res, 35(9), 844-849.
108. Higashida K,Kim S.H,Asaka Jung S.R,Holloszy al (2013). Effects of Resveratrol and SIRT1 on PGC-1α Activity and Mitochondrial Biogenesis: A Reevaluation. PLoS Biology, 11(7), e1001603.
109. Seo S,Chang Lee M.S,Oh Shin Y,et al (2015). Rutin Increases Muscle Mitochondrial Biogenesis with AMPK Activation in High-Fat Diet-Induced Obese Rats. Nutrients, 7(9), 8152-8169.
110. Yu Su K.Y,Chen Y.W,Huang Y.T,et Chen C.T (2014). Rutin, a Flavonoid and Principal Component of Saussurea Involucrata, Attenuates Physical Fatigue in a Forced Swimming Mouse Model. Int J Med Sci, 11(5), 528-537.
111. et Martins I.J (2015). Overnutrition Determines LPS Regulation of Mycotoxin Induced Neurotoxicity in Neurodegenerative Diseases. Int J Mol Sci, 16(12), 9554-2957.