Effect of Daily Treatment with Tadalafil on Serum Prorenin, Nephrin, Plasminogen Activator Inhibitor-1 and Interleukin-6 Levels in Type 2Diabetics in Relation to Microalbuminuria

Shatha H. Ali

Effect of Daily Treatment with Tadalafil on Serum Prorenin, Nephrin, Plasminogen Activator Inhibitor-1 and Interleukin-6 Levels in Type 2Diabetics in Relation to Microalbuminuria

Shatha H. Ali * §

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§ college of pharmacy -university of Baghdad-

Effect of Daily Treatment with Tadalafil on Serum Prorenin, Nephrin, Plasminogen Activator Inhibitor-1 and Interleukin-6 Levels in Type 2Diabetics in Relation to Microalbuminuria

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Abstract

Tadalafil is a phosphodiesterase-5(PDE-5) inhibitor, currently marketed for treating erectile dysfunction, as well as, for the treatment of pulmonary arterial hypertension.These are orally available drugs acting via intracellular signaling pathways, specifically the cyclic nucleotide monophosphate cyclic GMP, represents an important mediator in controlling of the outflow in region (kidney). The use of phosphodiesterase (PDE) inhibitor-5, tadalafil, is known to restrain the degradation of cyclic GMP, could offers a great opportunities in the treatment of kidney dysfunction associated with diabetes .Which may be assessed by testing for microalbuminuria that mostly precedes the development of overt diabetic nephropathy.

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Shatha Ali. . "Effect of Daily Treatment with Tadalafil on Serum Prorenin, Nephrin, Plasminogen Activator Inhibitor-1 and Interleukin-6 Levels in Type 2Diabetics in Relation to Microalbuminuria". Global Journal of Medical Research, Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 12 (GJMR Volume 12 Issue B9).

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GJMR Volume 12 Issue B9

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

Diabetic nephropathy interleukin-6 microalbuminuria nephrine plasminogen activator inhibitor-1 prorenin Tadalafil

Classification

GJMR-B Classification NLMC Code: WK 825

WK 840

WK 870

Submission ReceivedAugust 28, 2012
Peer Review Double Blind
Handling Editor
Accepted September 17, 2012
Published September 29, 2012

Version of record

v1.2

Language

English

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Article Matrices

Total Score: 148

Country: Iraq

Subject: Global Journal of Medical Research

Authors: Dr. Ziena Salah Najeb, Shatha H. Ali, Kalid Ibrahem Al-lheby (PhD/Dr. count: 1)

View Count (all-time): 143

Total Views (Real + Logic): 7962

Total Downloads (simulated): 194

Publish Date: 2012 09, Sat

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Total Views: 8K

Total Downloads: 194

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