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ReserarchID
23WXE
Crossref Journal DOI 10.17406/gjmra
Print ISSN 0975-5888
e-ISSN 2249-4618
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Diabetes mellitus (DM) induced hyperglycation of cellular and membrane proteins may result in altered ionic nature as well as an alteration in 3 dimensional structures of these molecules, thus resulting in a possible functional variation. Sialic acid (SA), a constituent of glomerular basement membrane (GBM) is a newly established potent indicator for the development of macro and microvascular complications in DM and its elevated levels are observed in DM patients with microalbuminuria and clinical proteinuria. Probably this elevation in SA may be due to increased SA release from the renal GBM due to hyperglycation. This biochemical alteration is the main initiating factor for the pathophysiology of diabetic complication, nephropathy. Diallyl disulphide (DADS), the principle compound of garlic oil, is well known for its anti-diabetic properties. Hence a study was undertaken to assess the anti-glycation properties of DADS and its usefulness in prevention of de-sialation of GBM, in alloxan diabetic kidneys, thereby to establish any beneficial effects of DADS in prevention of renal complications in DM. The current study showed a significant decrease (p
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