Effect of Emblica Officinalis on Stress Induced Biochemical and Psychological Changes in Mice

Effect of Emblica Officinalis on Stress Induced Biochemical and Psychological Changes in Mice

D. Yashwanth Kumar

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C. Pradeep Kumar

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Swathi Rawath.S

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K.S.S.N. Neelima

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Pacific University

Effect of Emblica Officinalis on Stress Induced Biochemical and Psychological Changes in Mice

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Abstract

Emblica officinalis Gaertn. (Euphorbiaceae) [EO] fruit is traditionally used as a general health tonic in Ayurveda. In the present study the effect of alcoholic extract of EO fruits was evaluated on acute stress induced biochemical and psychological changes in mice. Acute stress was induced by restraint stress method and the effect of EO at the doses of 100, 250 and 500mg/kg was evaluated on levels of plasma glucose and corticosterone. The level of anxiety induced by acute stress was measured by subjecting the mice to elevated plus maze. The extract at the doses of 250mg/kg and 500mg/kg significantly countered the stress induced elevated plasma glucose and cortisol levels. Likewise, the extract at the doses of 250 and 500mg/kg increased the number of entries and time spent in the open arm in elevated plus maze. In conclusion the Emblica officinalis fruit extract significantly reduces the adverse effects of stress on physical and mental health.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

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Not applicable for this article.

How to Cite This Article

D. Yashwanth Kumar. 2014. \u201cEffect of Emblica Officinalis on Stress Induced Biochemical and Psychological Changes in Mice\u201d. Global Journal of Medical Research - G: Veterinary Science & Medicine GJMR-G Volume 13 (GJMR Volume 13 Issue G2).

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GJMR Volume 13 Issue G2

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

Anxiety emblica officinalis Stress

Submission ReceivedDecember 9, 2012
Peer Review Double Blind
Handling Editor
Accepted January 4, 2013
Published January 15, 2013

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v1.2

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January 29, 2014

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Article Matrices

Total Score: 104

Country: India

Subject: Global Journal of Medical Research - G: Veterinary Science & Medicine

Authors: C. Pradeep Kumar, Swathi Rawath.S, D. Yashwanth Kumar, K.S.S.N. Neelima (PhD/Dr. count: 0)

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