Effect of Oral Administration of Chloramphenicol on Hematological Profile of Male Charles Foster Rats
For a given organism, relevant information about the internal environment can be easily accessed by its hematological profile. Chloramphenicol being a potent broad spectrum antibiotic is used readily in eyed drop formulations and is also in food industry. In the present study, varying doses (750, 1500 and 2250 mg/kg B.Wt) of Chloramphenicol (CAP) was administered orally as single daily dosage for 24 days to Male Charles Foster rats, to assess the hematological changes associated with oral exposure to the drug. The results showed a significant (p<0.05) dose dependent decrease in Red Blood Cells (RBC) count, Hemoglobin (Hgb), Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin Concentration (MCHC) and increase in Hematocrit (Hct), White Blood Cells (WBC) and Platelets compared to the initial blood profile. The results recorded in this present study suggested that exposure to CAP results in Hematotoxicity. Hence, the potential of CAP to cause hematotoxicity is reported in the study.
