Effect of Oral Administration of Chloramphenicol on Hematological Profile of Male Charles Foster Rats

P. Shukla
P. Shukla * §
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R. K. Singh
R. K. Singh
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§ CSIR- Central Drug Research Institute, Lucknow

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Effect of Oral Administration of Chloramphenicol on Hematological Profile of Male Charles Foster Rats

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Abstract

For a given organism, relevant information about the internal environment can be easily accessed by its hematological profile. Chloramphenicol being a potent broad spectrum antibiotic is used readily in eyed drop formulations and is also in food industry. In the present study, varying doses (750, 1500 and 2250 mg/kg B.Wt) of Chloramphenicol (CAP) was administered orally as single daily dosage for 24 days to Male Charles Foster rats, to assess the hematological changes associated with oral exposure to the drug. The results showed a significant (p

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

P. Shukla, R. Singh. 2013. "Effect of Oral Administration of Chloramphenicol on Hematological Profile of Male Charles Foster Rats". Global Journal of Medical Research, Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 13 (GJMR Volume 13 Issue B4).

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords
blood cellsCAPCF ratshematotoxicity
Classification
GJMR-B Classification NLMC Code: WB 350
  • Submission ReceivedDecember 8, 2012
  • Peer Review Double Blind
    Handling Editor
  • Accepted January 2, 2013
  • Published January 15, 2013
Version of record

v1.2

Issue date
July 10, 2013

Language
English
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Effect of Oral Administration of Chloramphenicol on Hematological Profile of Male Charles Foster Rats

P. Shukla
P. Shukla CSIR- Central Drug Research Institute, Lucknow
R. Singh
R. Singh
  • Submission ReceivedDecember 8, 2012
  • Peer Review Double Blind
    Handling Editor
  • Accepted January 2, 2013
  • Published January 15, 2013